| Cat.No. | Name | Information |
|---|---|---|
| M4839 | Cell Counting Kit-8 | Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays. |
| M1817 | Y-27632 dihydrochloride | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. |
| M5293 | Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability. |
| M1925 | LY294002 | LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. |
| M3850 | Dimethyl sulfoxide | Dimethyl sulfoxide (abbreviated DMSO) is a common organic solvent which has the strongest dissolving ability, it can dissolve most of the organic compounds. |
| M1902 | MG132 | MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). |
| M7528 | Phosphatase Inhibitor Cocktail (EDTA-Free) | AbMole Phosphatase Inhibitor Cocktail (EDTA-Free) is a mixture of phosphatase inhibitors prepared by 8 independent phosphatase inhibitors according to the optimized ratio. It is divided into A and B two tubes: A tube is a phosphate - root analogue to prevent the loss of phosphorylation of proteins and lipids, and B tube is a new natural product to provide more comprehensive protection for phosphorylation. |
| M4879 | Cycloheximide | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. |
| M9162 | Triton X-100 | Triton X-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40. |
| M1768 | Rapamycin | Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. |
| M4881 | Actinomycin D | Actinomycin d is a bright red rhomboid prisms or red powder. |
| M1837 | MK-2206 2HCl | MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| M5385 | Acetylcysteine (NAC) | Acetylcysteine (NAC; N-acetyl-l-cysteine) is a ROS inhibitor that antagonizes the activity of several proteasome inhibitors. It is also an inhibitor of the tumor necrosis factor TNF. |
| M2082 | Streptozotocin | Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative. *The compound is unstable in solutions, freshly prepared is recommended |
| M8692 | ML385 | ML385 was a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. ML385 inhibits Nrf2 transcription factor activity by binding to Neh1. |
| M2296 | 3-Methyladenine (3-MA) | 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively. |
| M6793 | HEPES | HEPES is a multipurpose buffer. |
| M1732 | Talazoparib (BMN-673) | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. |
| M1977 | U0126-EtOH | U0126-EtOH is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2. |
| M2238 | Dorsomorphin (Compound C) dihydrochloride | Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. |
| M2952 | PMSF | PMSF is an irreversible serine/cysteine protease inhibitor. |
| M5107 | DAPI solution | |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M9096 | H2DCFDA | H2DCFDA is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS). H2DCFDA can be used for the Bacterial reactive oxygen species (ROS) production assay. |
| M6164 | MCC950 | MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. |
| M4947 | Streptomycin sulfate | Streptomycin sulfate is an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. |
| M5106 | DAPI dihydrochloride | DAPI dihydrochloride is A fluorescent dye that binds DNA rich in a-T sequences. The maximum excitation/emission wavelength is 358nm/461 nm, and the blue fluorescence is often used to observe the nucleus and nucleic acid. Store at room temperature away from light. |
| M1781 | Adezmapimod (SB203580) | Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| M4647 | Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M8083 | MCC950 sodium salt (CP-456773) | MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. |
| M2076 | SP600125 | SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. |
| M1763 | Mirdametinib (PD0325901) | Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. |
| M5868 | Penicillin G Sodium | Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp. |
| M1820 | Tofacitinib | Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM. |
| M1796 | XAV939 | XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| M3637 | Puromycin dihydrochloride | Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor. |
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| M5558 | Deferoxamine mesylate | Deferoxamine mesylate as a chelating agent used to remove excess iron from the body. |
| M1894 | Rosiglitazone | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| M1692 | CHIR-99021 | CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M2698 | Ferrostatin-1 | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| M1712 | FTY720 hydrochloride | Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| M1664 | AZD2281 (Olaparib) | AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. |
| M9524 | Lipopolysaccharides | Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. This product is derived from Escherichia coli O55:B5. |
| M1759 | GSK1120212 (Trametinib) | Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. |
| M1715 | GDC-0941 (Pictilisib) | GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM. |
| M1746 | DAPT | DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. |
| M1646 | AG490 | AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). |
| M1970 | Paclitaxel | Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. |
| M3621 | Ionomycin | Ionomycin is a calcium ionophor and an antibiotic produced by Streptomyces conglobatus. |
| M5117 | CFSE (CFDA-SE) | Succinimide (CFSE) is a luciferase - based tracer that penetrates and immobilizes cells for extremely long-term cell labeling. The maximum excitation/emission wavelength is 494nm/521 nm. Fluorescent green. Store away from light. |
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M5112 | Hoechst 33342 | Hoechst 33342 (HOE 33342) is a cell membrane permeable nuclear staining reagent for DNA staining. The maximum excitation/emission wavelength is 361nm/497nm, and it gives blue fluorescence, which is often used to observe the nucleus/nucleolus. Store at 4°C away from light. |
| M1637 | ABT-263 | ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w. |
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M1749 | Gefitinib | Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. |
| M3946 | BML-275 | BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. |
| M2679 | Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended |
| M13565 | Hoechst 33342 trihydrochloride | Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain. Hoechst binds to the grooves in the DNA double strand, which tends to be A/T-rich DNA strand. Although it binds to all nucleic acids, the A/T-rich double strand DNA significantly enhances fluorescence intensity Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution. |
| M1988 | Dabrafenib | Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor. |
| M2066 | Staurosporine (AM-2282) | Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| M3988 | Sulforaphane | Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
| M5791 | Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. |
| M2053 | Wortmannin (KY 12420) | Wortmannin (KY 12420) is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM. |
| M5113 | Hoechst 33342 solution | Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA. |
| M1822 | PD98059 | PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway. |
| M1969 | Doxorubicin HCL | Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
| M9638 | 4-Phenylbutyric acid (4-PBA) | 4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. |
| M2052 | Decitabine | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
| M9109 | Corn oil | Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity. It can be used to construct animal models of hypospadias. |
| M1966 | Fulvestrant | Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. |
| M6327 | 2-NBDG | 2-NBDG is a fluorescent glucose uptake indicator. |
| M2062 | SB 202190 | SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| M8873 | D-Luciferin potassium salt | D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects. |
| M1708 | Selisistat (EX 527) | Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. |
| M2167 | (+)-JQ1 | (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. |
| M2424 | AZD9291 (Osimertinib) | AZD9291 is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively. |
| M9050 | MHY1485 | MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
| M1686 | Bortezomib (PS-341) | Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. |
| M5680 | Gemcitabine | Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| M9267 | Coelenterazine | Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.*The compound is unstable in solutions, freshly prepared is recommended |
| M9164 | Insulin(cattle) | Insulin is a peptide hormone produced by beta cells of the pancreatic islets. The compound is unstable in solutions, freshly prepared is recommended. |
| M2326 | Etoposide (VP-16-213) | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M4837 | SBE-β-CD (Sulfobutylether beta-cyclodextrin) | SBE-β-CD (Sulfobutylether beta-cyclodextrin) is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE). |
| M2081 | LY2109761 | LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2040 | BAY 11-7082 | BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| M5114 | Calcein-AM | Calcein-am is a fluorescent dye that penetrates cells and is used to measure cell viability. The excitation and emission wavelengths of Calcein are 494 nm and 517 nm, respectively. Fluorescent green. Store at -20℃ away from light. |
| M2008 | ICG-001 | ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. |
| M1861 | Silmitasertib (CX-4945) | CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2). |
| M9093 | DTT | Dithiothreitol (DTT) is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol (DTT) is also used to reduce the disulfide bonds of proteins. |
| M1671 | BEZ235 | BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively. |
| M1787 | INCB18424 | INCB18424 is a potent inhibitor of both JAK1 and JAK2 with selectivity versus JAK3 and TYK2 (IC50 values of 2.7, 4.5, 332, and 19 nM, respectively, in biochemical assays). |
| M7007 | MTT | MTT is a reagent used in the measurement of cell proliferation. |
| M2071 | ONX-0914 | Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. |
| M2191 | Forskolin | Forskolin (Coleonol) is a cell-permeable activator of adenylyl cyclase. |
| M3532 | VX-765 (Belnacasan) | VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. |
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). |
| M3466 | Indomethacin | Indomethacin is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. |
| M1661 | AZD6244 | AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM. |
| M2206 | TH-302 (Evofosfamide) | TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3807 | Ionomycin (Calcium salt) | Ionomycin is a calcium ionophor and an antibiotic produced by Streptomyces conglobatus. |
| M9336 | Insulin (Pig) | Insulin has anabolic properties that include the stimulation of both skeletal muscle and liver cells to incorporate glucose and convert it to glycogen, to synthesize proteins from amino acids in the blood, and to act on fat cells to enhance their uptake of glucose and the synthesis of fat. |
| M2315 | Necrostatin-1 | Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. |
| M9317 | Carboxymethyl cellulose sodium | Carboxymethyl cellulose sodium is frequently used as viscous agent, paste and barrier agent. |
| M2017 | ABT-199 (Venetoclax) | ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor. ABT-199 is the first inhibitor targeting Bcl-2 and PPI. |
| M6209 | Rotenone | Rotenone is an inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase, and is used to induce a Parkinson-like syndrome as an experimental model in rats. |
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M9878 | EDTA disodium | EDTA disodium is a chelating agent. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M1823 | Perifosine | Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| M6101 | Atezolizumab | Atezolizumab (atezolizumab) is a humanized anti-PD-L1 monoclonal antibody that inhibits PD-L1 signaling with PD-1 and B7-1 and restores tumor-specific T-cell immunity. However, it does not affect the interaction of PD-L2 with PD-1. MW: 145 KD. atezolizumab reacts with murine PD-L1 (for human and non-humanized mice). |
| M2569 | Dynasore | Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM. |
| M3241 | Imatinib | Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. |
| M6699 | EDTA | EDTA is a chelating agent. EDTA can activate NOTCH1 signaling. |
| M5567 | D-Glucose | D-Glucose (Glucose), a simple sugar (monosaccharide), is an important carbohydrate in biology. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2748 | GW9662 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1989 | CHIR-99021 HCl | CHIR-99021 HCl (CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively. |
| M3722 | Temsirolimus | Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
| M5122 | DiR iodide | |
| M3422 | Capsaicin | Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. |
| M1962 | Lenalidomide | Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. |
| M1898 | Plerixafor (AMD3100) | Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist. |
| M3115 | VE-822 (Berzosertib) | VE-822 (Berzosertib) is an ATR inhibitor with IC50 of 19 nM. |
| M1658 | Axitinib | Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit. |
| M1737 | MF63 | MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively. |
| M2080 | Capmatinib (INCB28060) | Capmatinib (INCB28060) is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM. |
| M1802 | Lapatinib Ditosylate | Lapatinib Ditosylate (CAS 388082-78-8) is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM). |
| M10272 | Fluorescein Sodium | Fluorescein Sodium is a phthalic indicator dye used as a diagnostic aid in corneal injuries and corneal trauma. |
| M6991 | Monensin sodium salt | Monensin Sodium Salt is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium Salt is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium salt causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes. |
| M7727 | CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M5108 | PI [Propidium iodide] | PI (propidium iodide) binds to DNA by inserting between bases. The maximum excitation/emission wavelength is 535nm/617 nm. It fluoresces red and needs to be stored at room temperature away from light. |
| M2108 | SB-525334 | SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. |
| M1806 | PD 0332991 HCL | PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M2289 | 5-fluorouracil | 5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M5228 | THZ1 | THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. |
| M2352 | 10058-F4 | 10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. |
| M2781 | IWP-L6 | IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| M5625 | Estradiol | Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone. It can be used to construct animal models of chronic non-bacterial prostatitis. |
| M5140 | 2-Deoxy-D-glucose | 2-Deoxy-D-Glucose is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which cannot be further metabolized by phosphoglucose isomerase. |
| M1913 | Neratinib | Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase. |
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M9422 | FB23-2 | FB23-2 is a potent and selective FTO inhibitor with an IC50 of 2.6 μM, directly binds to FTO and selectively inhibit FTO's m6A demethylase activity. |
| M2830 | Mdivi-1 | Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
| M2100 | Bleomycin sulfate | Bleomycin sulfate (Blenoxane) is a glycopeptide antitumor antibiotic isolated from Streptomyces verticillus. |
| M6105 | Testosterone | Testosterone is an androgen, which binds the androgen receptor. |
| M2335 | ZLN005 | ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator. |
| M9665 | N-(2-amino-2-oxoethyl)acrylamide | N-(2-Amino-2-oxoethyl)acrylamide |
| M4953 | Bafilomycin A1 | Bafilomycin A1 (BafA1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. |
| M3026 | Sorafenib (BAY 43-9006) | Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
| M3813 | Avelumab (MSB0010718C) | Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). Avelumab recognizes murine PD-L1 |
| M2176 | Dexamethasone | Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| M1709 | Everolimus | Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM. |
| M2977 | RGFP966 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. |
| M2112 | LY2835219 mesylate | LY2835219 mesylate is an orally available inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively. |
| M5307 | Afatinib dimaleate | Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. |
| M1819 | A66 | A66 is a potent and specific inhibitor of PI3K p110α with IC50 values of 32, 30 and 43 nM for p110α, p110α/E545K and p110α/H1047R. |
| M1825 | PCI-32765 | PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M1766 | PF-04217903 | PF-04217903 (PF-4217903) is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to142 nM. |
| M9850 | BODIPY 493/503 | BODIPY 493/503 is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells. |
| M5109 | PI solution | Propidium Iodide is a red-fluorescent dye that can be used to stain cells. |
| M1956 | Apatinib mesylate | Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor of VEGFR2 with an IC50 of 2.43 nM. |
| M7388 | TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor; orally active. |
| M19994 | PEG8000 | Polyethylene glycol 8000 (PEG 8000) is a polymer formed by condensation reaction of ethylene oxide and water. Polyethylene glycol is used for the isolation of plasmid DNA and the precipitation of phage. |
| M3194 | Nocodazole | Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. |
| M8128 | R1881 | R1881 (Metribolone) is an orally active, non-aromatisable androgen and anabolic steroid. |
| M1882 | Vatalanib dihydrochloride | Vatalanib is a selective small molecule protein kinase inhibitor of VEGF receptors 1-3. |
| M7871 | G15 | G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM. |
| M2903 | OTX015 (Birabresib) | OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. |
| M5037 | A 83-01 | A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended |
| M1827 | Sorafenib Tosylate | Sorafenib (BAY 43-9006) Tosylate is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. |
| M1738 | Niltubacin | Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6. |
| M1809 | NU7441 | NU7441 (KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 values of 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. |
| M5688 | Heparin sodium | Heparin sodium salt, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. |
| M3032 | Stattic | Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M8959 | BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) | BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is an inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 to 100 nM. |
| M9566 | Glycine | Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate. |
| M1761 | Vemurafenib (PLX4032) | Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. |
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