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-Bicuculline-chemical-structure.gif)
(+)-Bicuculline (1-100μM) dose-dependently inhibits the Cl- conductance generated by 40 μM GABA. (+)-Bicuculline inhibits GABA(A) α2/β1/γ2 currents activated by γ-Aminobutyric acid, (+)-Bicuculline concentration from 10 nM to 2 μM progressively decreased the amplitude of GABA-activated ion currents. Furthermore, (+)-bicuculine also blocks small-conductance calcium-activated potassium channels.
Int J Pharm. 2024 Aug 05.
Angiopep-2 conjugated biomimetic nano-delivery system loaded with resveratrol for the treatment of methamphetamine addiction
(+)-Bicuculline purchased from AbMole
Eur J Pharmacol. 2022 Apr 5;920:174806.
Dexmedetomidine attenuates motor deficits via restoring the function of neurons in the nigrostriatal circuit in Parkinson's disease model mice
(+)-Bicuculline purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Primary cortical neurons from rat E18 embryos |
| Preparation method | Bicuculline treatment could potentiate synaptic NMDAR signaling in the primary cortical neurons. Bicuculline led to a rapid decrease in STEP61 expression and a concomitant increase in the tyrosine phosphorylation of STEP substrates including GluN2B, Pyk2, and ERK1/2. |
| Concentrations | 10 μM |
| Incubation time | 15-60 min |
| Animal Experiment | |
|---|---|
| Animal models | Fischer-344 virgin female rats of Ovariectomy |
| Formulation | sesame oil + 10% DMSO |
| Dosages | 3.5 mg/kg daily |
| Administration | via osmotic subcutaneous pumps |
| Molecular Weight | 367.35 |
| Formula | C20H17NO6 |
| CAS Number | 485-49-4 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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