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| Cat.No. | Name | Information |
|---|---|---|
| M10476 | GDC-0575 (ARRY-575) | GDC-0575 (ARRY-575, RG7741) is a potent and selective oral inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. |
| M10475 | Lifirafenib (BGB-283) | Lifirafenib (BGB-283) is a novel potent and selective RAF Kinase and EGFR inhibitor with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. |
| M10474 | Delgocitinib (JTE-052) | Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor with IC50 values of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. |
| M10473 | MK-3118 | MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins. |
| M10472 | AZD3759 hydrochloride | AZD3759 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. |
| M10471 | MTI-31 (LXI-15029) | MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays. |
| M10470 | Raxatrigine hydrochloride | Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. |
| M10469 | MCH TFA (human, mouse, rat) | MCH TFA (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. |
| M10468 | N-Formyl-Met-Leu-Phe | N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion. |
| M10467 | Phosphocreatine disodium | Phosphocreatine disodium is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction, belongs to alpha amino acids and derivatives. |
| M10466 | Recombinant Mouse Interleukin-4 (IL-4) (E. coli) | Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. |
| M10465 | Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed) | Recombinant Mouse Interleukin-4 is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. |
| M10464 | EC5026 (BPN-19186) | EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. |
| M10463 | DIMBOA | DIMBOA is a powerful antibiotic present in maize, wheat, and related grasses, possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae. |
| M10462 | O-Acetyl-L-carnitine hydrochloride | O-Acetyl-L-carnitine hydrochloride is an acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS. |
| M10461 | Euparin | Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor, which exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. |
| M10460 | Recombinant Rat Insulin-like Growth Factor-1 (E. coli) | Recombinant Rat Insulin-like Growth Factor-1 belonged to the insulin gene family, it is mitogenic polypeptide growth factor that stimulates the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. |
| M10459 | MSA-2 | MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. |
| M10458 | Huwentoxin IV TFA | Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). |
| M10457 | PEG400 | PEG400 is a neutral and biocompatible hydrophilic polymer. |
| M10456 | VPC-80051 | VPC-80051 is a novel inhibitor of hnRNP A1 that targets the hnRNP A1 RBD. |
| M10455 | SB-4 | SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. |
| M10454 | JC-1 Mitochondrial Membrane Potential Assay Kit | JC-1 Mitochondrial Membrane Potential Assay Kit is a kit that uses JC-1 as a fluorescent probe to quickly and sensitively detect the transmembrane potential difference of tissues, cells or purified mitochondria. It can be used for early apoptosis detection. |
| M10453 | LY518674 | LY518674 is a potent and selective PPAR-alpha antagonist with EC50 of 42 nM for human PPARα. |
| M10452 | PFE-360 | PFE-360, also known as PF-06685360, is a potent and selective, brain penetrated inhibitor of LRRK2 kinase. |
| M10451 | WRW4 | WRW4 is a selective antagonist of formyl peptide receptor 1 (FPR1) signaling, it inhibits WKYMVm binding to FPR1 (IC50 = 0.23 μM). |
| M10450 | D-Ribose 5-phosphate disodium | D-Ribose 5-phosphate disodium is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. |
| M10449 | Oleic acid (Liquid) | Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is also a Na+/K+ ATPase activator. |
| M10448 | Myristic acid | Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. |
| M10447 | DMPC | 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) has the ability to enhance the constancy and in vitro antiproliferative effect of carmofur. |
| M10446 | 1400W dihydrochloride | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
| M10445 | Fluzoparib (SHR3162) | Fuzuopali is a poly (ADP-ribose) polymerase inhibitor (PARP) inhibitor with IC50 of 1.46±0.72 nM for a cell‐free enzymatic assay, with superior antitumor activity. |
| M10444 | Oteseconazole | Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd <39 nM). |
| M10443 | Linperlisib (YY-20394) | Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. |
| M10442 | Minodronic acid | Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors, Minodronic acid (YM-529) is also a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. |
| M10441 | Tofogliflozin (hydrate) | Tofogliflozin (CSG-452) hydrate is a potent and highly specific sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 value of 2.9 nM. |
| M10440 | Luseogliflozin | Luseogliflozin is a SGLT2 inhibitor, it reduced reabsorption of renal filtered glucose and decreased renal glucose threshold (RTG) in urine to increase urinary glucose excretion. |
| M10439 | Evocalcet | Evocalcet is a calcium-sensing receptor agonist. |
| M10438 | BI 882370 | BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive) conformation of the BRAF kinase. |
| M10437 | PF-06700841 | PF-06700841 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. PF-06700841 also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively. |
| M10436 | Belzutifan (PT2977) | Belzutifan (PT2977) is a second-generation orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. |
| M10435 | Difamilast | Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor. |
| M10434 | Olutasidenib (FT-2102) | Olutasidenib (FT-2102) is a highly potent and selective, orally active, brain penetrant mutant Isocitrate dehydrogenase 1 (IDH1) inhibitor, with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively. |
| M10433 | Bozitinib (PLB-1001) | Bozitinib (PLB-1001; CBT-101) is a highly selective, blood-brain barrier permeable c-MET kinase inhibitor. |
| M10432 | Difelikefalin (CR-845; FE-202845) TFA | Difelikefalin (CR-845; FE-202845) TFA is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). |
| M10431 | Recombinant Human Nesfatin-1 (E. coli) | Recombinant Human Nesfatin-1 is a metabolic polypeptide and is the N-terminal region of the precursor protein, Nucleobindin2 (encoded by NUCB2 gene). |
| M10430 | Recombinant Human TGF-α (E. coli) | Recombinant Human TGF-α, also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. |
| M10429 | Ciprofloxacin hydrochloride | Ciprofloxacin hydrochloride is a β-diketone antibiotic with a broad spectrum antibacterial activity. |
| M10428 | N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) | N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite, it is the important constituent of brain heteropolysaccharides (glycoproteins). |
| M10427 | OVA Peptide (257-264) TFA | OVA Peptide (257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb. |
| M10426 | 1,3-Benzoxazole-6-carboxylic acid | 1,3-Benzoxazole-6-carboxylic acid |
| M10425 | Dimethyl succinate (Standard for GC) | Dimethyl succinate is a biodegradable ester with low odor and low volatility and commonly serves as a flavoring agent that can be used in perfumery and personal are products, including skin-conditioning agents and emollient. |
| M10424 | Deoxyartemisinin | Deoxyartemisinin |
| M10423 | DT2216 | DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC). |
| M10422 | Sodium bicarbonate | Sodium bicarbonate is an inorganic salt used as a buffering agent and a pH adjuster, it also serves as a neutralizer. |
| M10421 | Sodium citrate (dihydrate) | Sodium citrate dehydrate is an anticoagulant and also used as a buffer and food preservatives. |
| M10420 | Proglumide | Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. |
| M10419 | Fmoc-Asn(Trt)-OPfp | Fmoc-Asn(Trt)-OPfp is a non-essential amino acid. |
| M10418 | Malvidin chloride | Malvidin (chloride) is a bioactive compound demonstrates antioxidant capacity with free radical scavenging properties in vitro. |
| M10417 | Delphinidin chloride | Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which can modulate JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells. |
| M10416 | Ac4ManNAz | Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
| M10415 | Curdlan | Curdlan is a polysaccharide produced by bacteria and a homopolymer of glucose with β-1,3-glucosidic linkage. |
| M10414 | Fmoc-3VVD-OH | Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| M10413 | Boc-Val-Cit-PAB | Boc-Val-Cit-PAB is a cleavable ADC linker used in making antibody-drug conjugates (ADCs). |
| M10412 | Val-cit-PAB-OH | Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker for making MC-Val-Cit-PAB, which is also known as MC-Val-Cit-PAB-OH. |
| M10411 | Fmoc-Val-Cit-PAB-PNP | Fmoc-Val-Cit-PAB-PNP is a cleavable peptide ADC linker which used in the synthesis of antibody-drug conjugates (ADCs). |
| M10410 | Fmoc-Val-Cit-PAB | Fmoc-Val-Cit-PAB-OH is a cleavable useful heterobifunational linker for making Antibody-Drug-Conjugates (ADC). |
| M10409 | Mc-Val-Cit-PAB | Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). |
| M10408 | SuO-Val-Cit-PAB-MMAE | SuO-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the peptide SuO-Val-Cit-PAB. |
| M10407 | PNU-159682 | PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin. |
| M10406 | N3-PEG3-vc-PAB-MMAE | N3-PEG3-vc-PAB-MMAE is a synthesized drug-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. |
| M10405 | Fmoc-Val-Cit-PAB-MMAE | Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADCs that consists of a ADC linker (Fmoc-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). |
| M10404 | Tosufloxacin tosylate hydrate | Tosufloxacin tosylate hydrate is a fluoroquinolone antibacterial agent used to treat susceptible infections. |
| M10403 | MC-Val-Cit-PAB-MMAF | MC-Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC with antitumor activity by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB. |
| M10402 | MC-GGFG-DX8951 | MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker. |
| M10401 | SPDP Crosslinker | SPDP crosslinker, or SPDP NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. *The compound is unstable in solutions, freshly prepared is recommended |
| M10400 | Val-Cit-PAB-MMAE | Val-Cit-PAB-MMAE is a MMAE derivative with a cleavable linker, which is useful to make MMAE conjugate for ADC. *The compound is unstable in solutions, freshly prepared is recommended |
| M10399 | LY-3310756 hydrochloride | LY-3310756 hydrochloride |
| M10398 | Mc-MMAE | Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC. *The compound is unstable in solutions, freshly prepared is recommended |
| M10397 | McMMAF | McMMAF is a protective group-conjugated MMAF. *The compound is unstable in solutions, freshly prepared is recommended |
| M10396 | Deruxtecan | Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |
| M10395 | MKC-3946 | MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
| M10394 | FL118 | FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. |
| M10393 | Eribulin mesylate | Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. |
| M10392 | Corticotropin | Corticotropin (ACTH) is a polypeptide hormone extracted from the anterior lobe of the pituitary gland of mammals, acts on the adrenal cortex, and has the effect of promoting the proliferation of adrenal cortex tissue and the production and secretion of corticosteroids. |
| M10391 | Osthole | Osthole (Osthol) is a natural antihistamine alternative with potential inhibition of histamine H1 receptor activity. |
| M10390 | Aminooxy-acetic acid (AOA) | Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. |
| M10389 | Aminoethoxyvinyl glycine hydrochloride | Aminoethoxyvinyl glycine hydrochloride is an ethylene synthesis inhibitor. It is used to study the roles of ethylene in plant processes such as gravitropism and fasciation/cresting. |
| M10388 | (+)-JQ1 PA | (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1 with IC50 of 10.4 nM. |
| M10387 | Thalidomide-NH-CH2-COOH | Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. |
| M10386 | MT-802 | MT-802 is a potent BTK degrader based on PROTAC technology, it induces Bruton's tyrosine kinase (BTK) knockdown. |
| M10385 | PROTAC KRASG12C Degrader-LC-2 | PROTAC KRASG12C Degrader-LC-2 is a potent first-in-class PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. |
| M10384 | Homo-PROTAC pVHL30 degrader 1 | Homo-PROTAC pVHL30 degrader 1 is a pVHL30 degrader based on PROTAC and a potent VHL inhibitor. |
| M10383 | Homo-PROTAC cereblon degrader 1 (OUN20985) | Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3. |
| M10382 | PROTAC SGK3 degrader-1 | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3. |
| M10381 | TD-165 | TD-165 is a PROTAC-based cereblon (CRBN) degrader. |
| M10380 | dBET57 | dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC) which exhibits significant and selective degradation of BRD4 BD1 but is inactive on BRD4 BD2. |
| M10379 | BSJ-03-123 | BSJ-03-123 is a novel, potent CDK6-selective small-molecule degrader (PROTAC). |
| M10378 | Cycloleucine | Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. |
| M10377 | AZD4205 | AZD4205 is a novel potent and selective janus kinase 1 (JAK1) inhibitor, with IC50 value of 73 nM. |
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