| Cat.No. | Name | Information |
|---|---|---|
| M58548 | p-Cresol glucuronide | p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
| M58545 | N-Hydroxypipecolic acid | N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection. |
| M58544 | Rotigaptide | Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP). |
| M58543 | Ro 363 hydrochloride | Ro 363 hydrochloride is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is also an effective inotropic stimulant. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility. |
| M58542 | P053 | P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC50 of 0.5 μM. P053 also acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. |
| M58541 | VU0650786 | VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. |
| M58540 | Mitochondrial fusion promoter M1 | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 (2 mg/kg; iv) alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury. |
| M58539 | AT 1001 | AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM. |
| M58538 | Sudoxicam | Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| M58536 | Recombinant Mouse CD5L Protein (HEK293, C-6His) | CD5 Antigen-Like (CD5L) is a soluble protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily. CD5L regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram-negative bacteria and the SRCR domain one of CD5L retains both the LPS and LTA binding activities. |
| M58535 | Recombinant Human CD5L Protein (HEK293, C-6His) | CD5 Antigen-Like (CD5L) is a soluble protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily. CD5L regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram-negative bacteria and the SRCR domain one of CD5L retains both the LPS and LTA binding activities. |
| M58534 | NS-102 | NS-102 is a selective kainate (GluK2) receptor antagonist. |
| M58533 | Recombinant Human GAPDH Protein (E. coli, C-His) | GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58532 | Oleamide | Oleamide is an endogenous fatty acid amide. |
| M58531 | Deoxycarnitine chloride | Deoxycarnitine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota. |
| M58530 | Benitrobenrazide | Benitrobenrazide (Hexokinase 2 inhibitor 1) is a hexokinase 2 (HK2) inhibitor with anticancer and antitumor activity. |
| M58529 | Recombinant Human Caspase-3 Protein (E. coli, N-His) | Caspase-3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. |
| M58528 | α-Glucosidase (from yeast) | α-Glucosidase is a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-glucosidase is used for the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters. It was also used in the measurement of glycosidase inhibition. |
| M58527 | 4-Acetoxy-3-methoxycinnamic acid | 4-Acetoxy-3-methoxycinnamic acid |
| M58525 | 5-Bromouridine | 5-Bromouridine is a purine nucleoside analog, with broad antitumor activity rely on inhibition of DNA synthesis, induction of apoptosis, etc. |
| M58524 | GDC-0927 | GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. |
| M58523 | Monobutyl phthalate | Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. |
| M58522 | Peroxidase (Horseradish) | Peroxidase (Horseradish) involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases. |
| M58521 | Testosterone sulfate (pyridinium) | Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. |
| M58520 | RIP1/RIP3/MLKL activator 1 | RIP1/RIP3/MLKL activator 1 is a potent, blood-brain barrier permeable anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. |
| M58519 | K-80003 | K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. |
| M58517 | 2'-Deoxyinosine | 2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| M58516 | Lactate calcium | Lactate calcium is an excellent calcium fortifier that works better than inorganic calcium. Lactate calcium is used as an antacid. |
| M58515 | CDDO-TFEA | CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
| M58513 | 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate | 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate is a fluorescent dye. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate can be used in the diagnosis of mucopolysaccharidosis IV A by detecting activity of galactose-6-sulphate sulphatase. |
| M58512 | λ-Carrageenan | λ-Carrageenan is a seaweed polysaccharide, it is a potent antitumor agent. λ-Carrageenan has been generally used as proinflammatory agent in the basic research. |
| M58510 | Recombinant Mouse GAPDH Protein (E. coli, N-His) | GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58507 | Recombinant Human Galectin-3 Protein (HEK293, C-His) | Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain. LGALS3 (Galectin 3) has an important role in tumor progression through inhibition of apoptosis. |
| M58506 | Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. |
| M58504 | Cyclocreatine | Cyclocreatine acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. |
| M58502 | 4-Hydroxyestrone | 4-Hydroxyestrone (4-OHE1) is an estrone metabolite, it has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. |
| M58501 | Phentolamine | Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. |
| M58500 | EverFluor Fl C5-Ceramide | BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em= 505 nm/512 nm |
| M58499 | BODIPY TR Ceramide | BODIPY TR Ceramide (Golgi-Red Tracke) is a Golgi-specific fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em=589 nm/616 nm |
| M58498 | SR-4995 | SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling. |
| M58492 | CS-6253 | CS-6253 is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles. |
| M58491 | Trypsin (bovine pancreas) | Trypsin is a serine protease in the digestive system of human and animals. The main function of this enzyme is to hydrolyze proteins into smaller peptides or even amino acids. |
| M58490 | Sulfo-Cy5.5 maleimide | Sulfo-Cy5.5 maleimide |
| M58489 | Cyanine5.5 maleimide | Cyanine5.5 maleimide |
| M58488 | Z-VAD | Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. |
| M58487 | NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively. |
| M58486 | XST-14 | XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 has antitumor effects. |
| M58485 | Vacuolin-1 | Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. |
| M58484 | Torcitabine | Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection research. Torcitabine (2'-Deoxy-L-cytidine) shows greater inhibition of first strand than second strand DNA synthesis. |
| M58483 | N-Acetyl-L-cysteine ethyl ester | N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. |
| M58480 | Nenocorilant | Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. |
| M58478 | BODIPY TR methyl ester | BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo. BODIPY TR methyl ester is a lipophilic GFP counterstain, it readily permeates cell membranes and localizes in endomembranous organelles. |
| M58476 | SGK1-IN-4 | SGK1-IN-4 is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 can be used for the research of osteoarthritis. |
| M58475 | DDR2-IN-1 | DDR2-IN-1 is potent DDR2 inhibitor with an IC50 of 26 nM. DDR2-IN-1 can be used for osteoarthritis research. |
| M58474 | C14 Ceramide | C14 Ceramide is an ester product. |
| M58473 | SLC3037 | SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| M58470 | WL47 TFA | WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA can be used for the study of caveolin-1 function. |
| M58469 | CS-6253 TFA | CS-6253 TFA is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 TFA improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 TFA generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles. |
| M58468 | Thyroid hormone receptor antagonist (1-850) | Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. |
| M58467 | Chitosan (≥95% deacetylated, MW 50000-60000) | Chitosan (≥95% deacetylated, MW 50000-60000) is a polycationic linear polysaccharide derived from chitin .Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
| M58464 | IR-780 | IR-780 is a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity. The maximum excitation wavelength of IR-780 was 777-780 nm, and the maximum emission wavelength was 798-823 nm. IR-780 can be used in cancer PTT/PDT and imaging. |
| M58463 | WDR5-IN-4 | WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity. |
| M58462 | SSK1 | SSK1 is a senescence-specific killing compound and is a precursor for β-galactosidase, which can reduce the inflammatory response. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, promote mitochondrial DNA damage and selectively killed senescent cells. |
| M58461 | p38 MAP Kinase Inhibitor III | p38 MAP Kinase Inhibitor III is a p38 MAPK inhibitor with an IC50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively. |
| M58460 | NAD sodium | NAD sodium (β-Nicotinamide adenine dinucleotide sodium salt) is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP. |
| M58458 | MR-L2 | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM. |
| M58456 | Allo-aca | Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models. |
| M58455 | VRK-IN-1 | VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders. |
| M58454 | CO23 | CO23 is a selective thyroid hormone receptor (TR) α agonist, it is used for growth and development regulation. CO23 can be transported through the blood-brain barrier. |
| M58453 | Recombinant Human BMP-6 (E.coli, C-His) | Bone Morphogenetic Protein-6 (BMP-6) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-6 can bind with the TGF-β receptor and triggers SMAD protein signal transduction. It plays a vital role in regulating hepcidin to maintain iron ions in the body. |
| M58452 | DSPE-Se-Se-PEG2000 | DSPE-Se-Se-PEG2000 is a functional polyethylene glycol (DSPE-PEG) liposome derivative with disulfide bond linkage that plays an important role in gene delivery. This liposome is able to encapsulate DNA or RNA genes and protect them from various intracellular degradations and damages, as well as improve the efficiency and stability of gene transfection. |
| M58451 | Sevabertinib | Sevabertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with antitumor activity. |
| M58450 | Angiopep-2-Cys TFA | Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride and cysteine. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer. |
| M58449 | Orange G | Orange G is a dye used primarily as a histological stain. It can be used as a biological material or organic compound for life science related research. |
| M58447 | 1alpha-Hydroxy VD4 | 1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells. |
| M58446 | HKOCl-4 | HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm. |
| M58445 | Hydroxyphenyl Fluorescein | Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm. |
| M58441 | Sabirnetug | Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein. |
| M58440 | Soquelitinib | Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease. Soquelitinib increases tumor infiltration of normal CD8+ cells that possess enhanced T effector function. |
| M58439 | Ozekibart | Ozekibart is an anti-TNFRSF10B monoclonal antibody. |
| M58438 | Tividenofusp alfa | Tividenofusp alfa (DNL-310) is a fusion protein composed of IDS fused to Denali's proprietary Enzyme Transport Vehicle (ETV). |
| M58437 | LB-102 | LB-102 is an orally active inhibitor of dopamine D2, D3, and 5-HT7 receptors. |
| M58435 | Pifithrin-α, p-Nitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
| M58428 | EpoY | EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP), shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). |
| M58427 | Tetrahydrouridine | Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
| M58425 | Acridine Orange | Acridine Orange is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. |
| M58421 | DC-Y13-27 | DC-Y13-27, a derivative of DC-Y13, is a YTHDF2 inhibitor (KD = 37.9 μM). DC-Y13-27 enhances tumor responses to radiotherapy and immunotherapy. |
| M58419 | L-Leucyl-L-Leucine methyl ester hydrochloride | L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress. |
| M58418 | Crisnatol | Crisnatol (BWA770U) is a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells. Crisnatol (BWA770U) is also an orally active and anticancer agent. |
| M58417 | C6 Ceramide | C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. |
| M58416 | CCB02 | CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. |
| M58415 | Cu(II)-Elesclomol | Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. |
| M58414 | GAK inhibitor 49 | GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. |
| M58413 | MMP2-IN-1 | MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| M58411 | PV-1019 | PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits IR-induced apoptosis. |
| M58410 | Risvodetinib | Risvodetinib (IkT-148009) is an orally active, selective and brain-penetrant protein tyrosine kinase inhibitor, displaying excellent target efficacy against c-Abl1, c-Abl2/Arg with IC50 values of 33 nM, 14 nM, respectively. |
| M58409 | CM-444 | CM-444 is an inhibitor for HDAC and DNA methyltransferases (DNMT) with IC50 values of 6 nM-0.6 μM and 1.8-2.3 μM, respectively. CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models. |
| M58408 | CM-1758 | CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 inhibits tumor growth in vivo. CM-1758 induces acetylation of non-histone proteins in acute myeloid leukemia cells. |
| M58405 | Nanaomycin A | Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. |
| M58404 | Rosoxacin | Rosoxacin (Acrosoxacin) is an orally active and broad-spectrum antibacterial quinolone antibiotic. Rosoxacin inhibits Gram-negative bacteria, including N. gonorrhoeae (MIC range=0.03-0.125 µg/mL). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
