| Cat.No. | Name | Information |
|---|---|---|
| M58977 | Isolithocholic acid | Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. |
| M58974 | Codrituzumab-MMAE (CHO) | Codrituzumab-MMAE is an antibody-drug conjugate (ADC). Codrituzumab is a monoclonal antibody targeting GPC3 (glypican-3). |
| M58973 | FITC Palmitate | FITC-Palmitate is a fluorescently labelled fatty acid derivative made by chemically coupling fluorescein isothiocyanate (FITC) with a long chain fatty acid, palmitic acid. Due to its combination of fat solubility and green fluorescent signals, it has a variety of uses in biomedical and cell biology experiments. |
| M58972 | Agarose (high strength) | Agarose is a kind of polysaccharide that can be derived from seaweed, modified with hydroxyethyl and methoxy groups on the polysaccharide chain, which is suitable for in-gel enzymatic reactions, tissue culture, cell cloning and viral vacuole analysis and other related studies. It is commonly used in molecular biology and biochemistry to isolate and purify DNA and RNA fragments. |
| M58971 | Agarose (Low Melting Point) | Agarose is a kind of polysaccharide that can be derived from seaweed, modified with hydroxyethyl and methoxy groups on the polysaccharide chain, which is suitable for in-gel enzymatic reactions, tissue culture, cell cloning and viral vacuole analysis and other related studies. It is commonly used in molecular biology and biochemistry to isolate and purify DNA and RNA fragments. |
| M58970 | NCOA4-9a | NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| M58968 | Mito-Lonidamine | Mito-Lonidamine (Mito-LND) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-Lonidamine inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells. |
| M58966 | Azido-PEG2-CH2COOH | Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. |
| M58965 | ALKBH5-IN-3 | ALKBH5-IN-3 is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells. |
| M58964 | 2-Deoxy-2-fluoro-D-glucose | 2-Deoxy-2-fluoro-D-glucose is a radiolabeled glucose analog, which is commonly used in medical imaging techniques such as positron emission tomography (PET) scans. |
| M58963 | DOTA-NHS-ester | DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors. |
| M58962 | Odapipam | Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer. |
| M58961 | 1-Palmitoyl-sn-glycero-3-phosphocholine | 1-Palmitoyl-sn-glycero-3-phosphocholine is an lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the research of atherosclerosis. |
| M58960 | PGSK diacetate (5/6-mixture) | PGSK diacetate (5/6-mixture) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. PGSK diacetate can react with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+, etc. PGSK diacetate chelates Fe2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of PGSK diacetate are 507/532 nm, respectively. |
| M58959 | Dextran-Rhodamine B | Dextran-Rhodamine B (RB-Dextran) is a fluorescent marker made by combining rhodamine B fluorescent dye and dextran polysaccharide through a specific chemical reaction. RB-Dextran is a red fluorescent modified dextran polysaccharide formed by chemically labeling rhodamine B onto dextran molecules, which can be used in cell tracing, biofluid dynamics research and other fields, and its fluorescent properties can be used to track the distribution and metabolism of dextran in organisms and other processes. |
| M58958 | Butyryl Cholinesterase (Horse serum) | Butyryl Cholinesterase is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE) but has different substrate specificity and inhibitor sensitivity. The enzyme is a tetrameric glycoprotein composed of four identical subunits (110 kDa each) and is also known as pseudocholinesterase. It is synthesised in the liver and distributed in blood, neuromuscular junction synapses, glial cells and white matter axons. |
| M58957 | Nab-Paclitaxel | Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel. Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. |
| M58956 | L-Citrulline DL-Malate | L-Citrulline DL-malate is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate can be used in the field of agriculture to enhance plant immunity. |
| M58955 | Creatine-d3 | Creatine-d3 is the deuterium labeled Creatine. Creatine is an endogenous amino acid derivative, which plays an important role in cellular energy, especially in muscle and brain. |
| M58954 | Creatinine-d3 | Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle. |
| M58953 | N-Succinimidyl 6-(2,4-Dinitroanilino)hexanoate | N-Succinimidyl 6-(2,4-Dinitroanilino)hexanoate, the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. |
| M58952 | Urolithin M7 | Urolithin M7 is a metabolite, which is derived from the transformation of ellagitannins, compounds found predominantly in pomegranates, berries, and nuts. This transformation occurs via intestinal microbiota, which convert ellagitannins into various urolithins, including Urolithin M7. Its mode of action involves influencing cellular processes, potentially modulating mitochondrial function and autophagy pathways. |
| M58951 | Deoxyribonucleic Acid (from Salmon sperm) | Deoxyribonucleic Acid (from Salmon sperm) can be used as a research reagent, widely used in molecular biology, pharmacology and other scientific research. |
| M58950 | Recombinant Human Semaphorin 5A (HEK293, C-6His) | Semaphorin-5A (SEMA5A) is a member of the Semaphorin family of axon guidance molecules. SEMA5A mutations have been implicated in the genetic syndrome,cri-du-chat,while some polymorphisms may increase risk for neurodegenerative diseases such as Parkinson. The expression of SEMA5A may be upregulated in metastatic cancer cells and downregulated in autism. |
| M58949 | PMX 205 acetate | PMX 205 acetate is a potent complement C5a receptor (C5aR; CD88) antagonist. |
| M58948 | β-Glucosidase (from Almonds) | β-Glucosidase is the main component of glycoside hydrolases that hydrolyse Glucoside into glucose and other constituents. β-Glucosidase works by breaking down fibre-rich cell walls to release and utilise the nutrients such as proteins and starch contained therein, while at the same time degrading the fibre to reducing sugars that can be digested and assimilated by the body of the animal. |
| M58947 | L-Ornithine-15N2 hydrochloride | L-Ornithine-15N2 hydrochloride is the 15N-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen. |
| M58946 | D-Glucose-13C6 | D-Glucose-13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard. |
| M58945 | FITC-Arachidonic Acid | FITC-Arachidonic Acid is a fluorescent labelled compound for biomedical research. FITC-Arachidonic Acid combines the biological activity of arachidonic acid and the fluorescent properties of FITC, and is suitable for the study of cellular signalling, lipid metabolism and so on. |
| M58944 | Arachidonic acid-biotin | Arachidonic acid-Biotin is a biotin-labeled Arachidonic acid that can be used to detect complexes of arachidonic acid with protein binding partners such as fatty acid binding proteins (FABPs). |
| M58943 | HBpep(RPY)-SP acetate | HBpep(RPY)-SP acetate is a variant of the polypeptide HBpep-SP. HBpep(RPY)-SP acetate interacts with lipid bilayers and has demonstrated exceptional transfection efficiency in challenging-to-transfect cells, such as primary and immune cells. HBpep(RPY)-SP acetate is useful for research in protein, gene, and immune cell therapies. |
| M58942 | Recombinant Human TRIM21 Protein (E. coli, N-His) | TRIM21 Protein, an E3 ubiquitin ligase, plays a vital role in the immune response by targeting intracellular pathogens for degradation. It is involved in the recognition and clearance of viral particles. E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. |
| M58941 | Recombinant Human GDF-15 Protein (HEK293 N-hFc) | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| M58714 | D-Alanine | D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR. |
| M58711 | Diaphorase | Diaphorase has been used in a study to assess the protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism. |
| M58710 | Recombinant Human PD-L1 Protein (HEK293, C-Fc) | PD-L1 (also known as CD274, B7-H1) is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. |
| M58709 | Recombinant Human FGFR1 Protein (HEK293, C-His) | FGFR1, also known as CD331, is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. |
| M58708 | Recombinant Human FGFR2 Protein (HEK293, C-His) | FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. |
| M58705 | 2-Bromo-4-chlorophenylacetic acid | 2-Bromo-4-chlorophenylacetic acid is a biochemical reagent. |
| M58704 | 4-methylumbelliferyl α-D-glucopyranoside | 4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate for α-glucosidase (GAA), which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. |
| M58703 | Lactiflorin | Lactiflorin is a monoterpene glycoside from paeony root, which possesses nephroprotective effect. |
| M58702 | Quercetin 7-glucuronide | Quercetin 7-glucuronide can inhibit LDL oxidation. Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide) can be isolated from Madagascarian Uncarina species. |
| M58701 | Strictinin | Strictinin is a phenolic compound which has potential antiviral, antibacterial and laxative activities. Strictinin occurs by accelerating intestinal transit rather than enhancing gastric emptying, increasing food intake, or inducing diarrhea in rats. |
| M58700 | CPN-351 TFA | CPN-351 TFA is a selective pentapeptide antagonist of human NMUR1 with a pA2 of 7.35. CPN-351 TFA can be used for the research of inflammation. |
| M58699 | 5-Phenyluracil | 5-Phenyluracil is a pyrimidine derivative, a class of heterocyclic aromatic organic compounds crucial in biochemistry. It serves as a synthetic nucleoside analogue, meaning it mimics the structure of naturally occurring nucleosides like uridine. This structural similarity allows it to participate in biochemical reactions, often interfering with normal cellular processes, making it a valuable tool in studying nucleic acid metabolism and developing antiviral and anticancer agents. |
| M58697 | Cyanine7 amine | Cyanine7 amine is a near infrared dye with free amine group for the conjμgation with activated esters and other reactive molecules. |
| M58696 | Recombinant Mouse BMP-4 Protein (E. coli, C-His) | Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures. |
| M58694 | Puromycin-d3 | Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. |
| M58693 | BSH-IN-1 | BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. |
| M58692 | AAA-10 | AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively. |
| M58691 | Gut restricted-7 | Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice. |
| M58690 | D-Tryptophan | D-Tryptophan is the D-isomer of tryptophan, as a non-protein active amino acid, has special physiological properties, can be used as additives, plant growth agents, etc. In the pharmaceutical industry, it is mainly used in the synthesis of various polypeptides, instead of L-tryptophan to extend the peptide half-life. |
| M58689 | Naftazone | Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation. Naftazone can be used for the research of venous insufciency. |
| M58688 | 7-Deoxyloganin | 7-Deoxyloganin is a biosynthetic precursor of Loganin. 7-Deoxyloganin undergoes hydroxylation catalyzed by 7-deoxyloganin 7-hydroxylase, a cytochrome P450-dependent monooxygenase, to produce Loganin. |
| M58687 | KX2-361 | KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. |
| M58686 | Recombinant Human Coagulation Factor X (HEK293, C-Fc) | Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
| M58685 | Mannose-BSA | Mannose-BSA is an important organic intermediate that combines the properties of mannose and bovine serum albumin, which is of unique value in the field of scientific research, and can be used as a key substance in a variety of organic synthesis reactions. Mannose is an important monosaccharide that binds specifically to mannose receptors (e.g., CD206 receptors on dendritic cells and macrophages), and therefore has a wide range of applications in immunomodulation and targeted drug delivery. BSA is a protein carrier that is commonly used for biocoupling, and its abundant surface amino groups can covalently bind to mannose to form a mannose-BSA complex. |
| M58684 | Delgrandine | Delgrandine is a Alkaloids product that can be isolated from the herbs of Delphinium davidii. Delgrandine demonstrates high binding affinities for GRIN2B (also known as NMDAR2B) and ERK. Delgrandine displayed a high affinity for CAMK2A (also known as CaMKIIα). Delgrandine exhibited high binding affinity with NMDAR2B (−11 kcal/mol), CaMKIIα (−14.3 kcal/mol), and ERK (−10.8 kcal/mol). |
| M58683 | Methoctramine tetrahydrochloride | Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. |
| M58682 | Flurandrenolide | Fludroxycortide is a synthetic topical steroid with anti-inflammatory effects and has potential for research of skin irritation. |
| M58680 | Traumatic Acid | Traumatic acid (Trans-2-dodecenedioic acid) is the product of a biosynthetic pathway from a physiological role of alpha-ketol fatty acids in plant lipid hydroperoxide lyase metabolism. Traumatic acid (Trans-2-dodecenedioic acid) is also used in would healing as it stimulates cell division to form a protective callus around the wound site. |
| M58679 | T-00127-HEV1 | T-00127-HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM. |
| M58678 | MORF-627 | MORF-627 is a selective, orally active inhibitor for integrin αvβ6 with an IC50 of 9.2 nM (measuring by human serum ligand binding assay). MORF-627 inhibits αvβ6-mediated TGF-β1 activation with an IC50 of 2.63 nM, inhibits SMAD2/3 phosphorylation with an IC50 of 8.3 nM. |
| M58677 | TMTP1 Peptide | TMTP1 is a 5-amino acid peptide NVVRQ, it can be used for the labeling of malignant in situ and metastatic lesions, and even micro-metastases. TMTP1 specifically bound to the cells of a series of hematological malignancies, including HL60, k562, Jurkat, Raji, El-4 and chronic myeloid leukemia primary cells but not to bone marrow mononuclear cells from healthy subjects. TMTP1, as a novel tumor-homing peptide, can serve as a marker for primary malignant and metastatic lesions. |
| M58676 | c-di-AMP disodium | c-di-AMP disodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. |
| M58675 | 25-OH Vitamin D3/BSA | 25-OH Vitamin D3/BSA is an antigen-adjuvant coupling of 25-OH Vitamin D3 conjugated to bovine serum albumin (BSA). |
| M58674 | Recombinant Human LAG-3 Protein (HEK293, C-hFc) | Lymphocyte activation gene 3 protein (LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. It can lead to increased antigen-specific T-cell responses in vivo. |
| M58673 | Lipase (pocine pancreas) | Lipase is a class of enzymes with a variety of catalytic abilities that catalyse the hydrolysis of ester bonds at the lipid-water interface, and can catalyse the hydrolysis, alcoholysis, esterification, transesterification and reverse synthesis reactions of triacylglycerol esters and some other water-insoluble esters. Lipase can be used in biochemical research, analysis of prostaglandin esters and triglycerides in serum, and fat analysis. |
| M58672 | ZINC00784494 | ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. |
| M58671 | Sulfo-NHS-Biotin | Sulfo-NHS-Biotin stongly label single SDS-2ME soluble cuticular protein. |
| M58670 | Arachidonic acid sodium salt | Arachidonic acid sodium salt (Sodium Arachidonate) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). |
| M58669 | 4-ONE | 4-ONE is one of the major hemolytic decomposition products of lipid hydroperoxides. 4-ONE is a potent transient receptor potential ankyrin 1 (TRPA1) agonist. |
| M58668 | BODIPY TR Cadaverine | BODIPY TR Cadaverine is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A. |
| M58667 | DOPG sodium | DOPG sodium is a naturally occurring anionic phospholipid, containing oleic acid (18:1) inserted at the sn-1 and sn-2 positions. DOPG can form a lipid bilayer in an aqueous solution and is used in the generation of micelles, liposomes, and other artificial membranes. |
| M58666 | GSK4418959 | GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. |
| M58665 | GDC-2992 | GDC-2992 is an orally active androgen receptor (AR) degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. |
| M58664 | AMG410 | AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. |
| M58662 | GAPDH-IN-1 | GAPDH-IN-1 (GAPDH Inhibitor Compound F8) is a covalent inhibitor of GAPDH (IC50 = 39.31 µM). It viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. |
| M58661 | KP-457 | KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with IC50 of 11.1 nM (cell-free assay). KP-457 also cleaves various molecules such as GPIbα, GPV, and TNF-α. |
| M58660 | Carbonic anhydrase (Bovine erythrocytes) | Carbonic anhydrase, Bovine erythrocytes (EC 4.2.1.1) is ubiquitous zinc-containing metalloenzyme present in prokaryotes and eukaryotes. Carbonic anhydrase can catalyze reversible conversion of carbon dioxide to bicarbonate and protons. |
| M58659 | Recombinant Human GC1q-R Protein (E. coli, C-6His) | GC1q-R Protein (C1QBP; HABP1) is a nucleus protein that belongs to the MAM33 family. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. |
| M58658 | Cynomorium Songaricum Polysaccharides (≥98.0%) | Cynomorium Songaricum Polysaccharides is an acidic heteropolysaccharide extracted from lock yang, which mainly contains glucose, sucrose, polysaccharides, homopolysaccharide SYP-A and so on. Cynomorium Songaricum Polysaccharides has immunomodulatory, anti-aging and anti-fatigue activities. |
| M58656 | O-acetylcamptothecin | O-acetylcamptothecin is a derivative of camptothecin, a naturally occurring alkaloid extracted from the bark of the Chinese tree Camptotheca acuminata. Camptothecin and its derivatives are primarily known for their potent anticancer properties, particularly through their action as inhibitors of topoisomerase I, an enzyme critical for DNA replication and transcription. |
| M58655 | Sudan Black B | Sudan Black B, a fat-soluble diazo dye, is a histochemical stain. Sudan Black B can be used for staining of neutral triglycerides and lipids. |
| M58654 | 10-hydroxystearic acid | 10-hydroxystearic acid is a hydroxy fatty acid. |
| M58652 | SB-T-1214 | SB-T-1214 is a new-generation taxoid. SB-T-1214 possesses significant activity against colon cancer spheroids induced by and enriched with drug resistant tumorigenic CD133high/CD44high cells and efficiently inhibited expression of the majority of stem cell-related genes. |
| M58650 | trans-Vaccenic acid | trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. |
| M58649 | NG-497 | NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. |
| M58648 | Mead acid | Mead acid (5,8,11-Eicosatrienoic acid) is an unsaturated (Omega-9) fatty acid. |
| M58647 | BzATP triethylammonium | BzATP triethylammonium salt acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. |
| M58646 | HRS-4642 | HRS-4642 is a selective KRAS(G12D) inhibitor, with Kd value of 0.083 nM. HRS-4642 has anti-cancer activity. HRS-4642 exhibits significant in vivo potency. |
| M58645 | AZD0022 | AZD0022 is a selective and orally active KRASG12D inhibitor. |
| M58644 | Setidegrasib | Setidegrasib is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib has antitumor effect. |
| M58643 | L-Arginine-13C6,15N4 hydrochloride | L-Arginine-13C6,15N4 hydrochloride is the 13C- and 15N-labeled L-Arginine hydrochloride. |
| M58641 | 20α-Hydroxycholesterol | 20α-Hydroxycholesterol is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20α-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors. 20α-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells. |
| M58640 | IL-17A modulator-2 | IL-17A modulator-2 is a IL-17A modulator. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases associated with modulation of IL-17A activity. |
| M58639 | Propargyl-PEG1-acid | Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs. BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| M58638 | PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. |
| M58637 | PD0325901-O-C2-dioxolane | PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader. |
| M58636 | AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. |
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