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| Cat.No. | Name | Information |
|---|---|---|
| M11483 | A 438079 | A 438079 is A potent, selective P2X7 receptor antagonist with A pIC50 of 6.9. |
| M11482 | A 438079 hydrochloride | A 438079 Hydrochloride is A potent, selective P2X7 receptor antagonist with A pIC50 of 6.9. |
| M11481 | Abatacept | Abatacept is a CTLA-4 agonist that binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. |
| M11480 | Bmp-7 protein, Human (E. coli) | The BMP-7 protein, Human, is a potent bone morphogenetic protein and part of the transforming growth factor (TGF-β) superfamily. |
| M11479 | (-)-Taxifolin | (-)-Taxifolin is a low activity isomer of Taxifolin. Taxifolin has important anti-tyrosinase activity. Taxifolin effectively inhibited collagenase with IC50 of 193.3 μM. Taxifolin is an important natural compound with anti-fibrosis effects. Taxifolin is a free radical scavenger with antioxidant capacity. |
| M11478 | Sucrose acetate isobutyrate | Its a high purity liquid fatty acid sucrose ester, is also a surfactant. |
| M11477 | Colcemid | Colcemid (Demecolcine) is an effective mitotic inhibitor. Colcemid binds tubulin and blocks cells for metaphase karyotype analysis. Colcemid can induce apoptosis and can be used in tumor research. |
| M11476 | Disodium nitrilotriacetate | Disodium nitrilotriacetate is used as a chelating agent, which forms coordination compounds with metal ions such as Fe3+, Cu2+, and Ca2+. |
| M11475 | Lithium sulfate | To study the effects of manic depressive psychosis. |
| M11474 | EZM0414 | EZM0414 is a potent, selective, oral bioavailable SETD2 inhibitor (IN SETD2 biochemical analysis, IC50=18 nM; In cell analysis, IC50=34 nM). EZM0414 can be used to study relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma. |
| M11473 | BAY 2666605 | BAY 2666605 is an oral active PDE3A and PDE3B inhibitor with IC50 of 87 nM and 50 nM, respectively. BAY 2666605 is a pDE3A-SLFN12 compound inducer (WO2019025562A1; Example, 135). |
| M11472 | TRULI | TRULI inhibits Lats1 and Lats2 with IC50 of 0.2 nM, inhibits Yap phosphorylation, induces cell proliferation of multiple cell lines and tissues, and promotes the initial stage of proliferation and regeneration of sensory receptors in the inner ear. |
| M11471 | Recombinant Human CCL5 protein（E.coli） | Protein construction: The DNA sequence encoding human CCL5 (SER24-SER91) was fused with the GST marker Biological activity: Chemokines for blood monocytes, memory T helper cells and eosinophils. Cause basophils to release histamine and activate eosinophils. |
| M11470 | Bis Acrylamide | |
| M11469 | Acrylamide | Acrylamide is a neurotoxic monomer with a wide range of industrial uses. It is a precursor compound of polyacrylamide. |
| M11468 | Coenzyme A | Coenzyme A is an essential cofactor in all living cells synthesized by Vitamin B5, ATP, and cysteine. |
| M11467 | GSK-2250665A | GSK-2250665A is a Itk inhibitor with pKi value of 9.2. |
| M11466 | Sinapinic acid | Sinapinic acid (Sinapic acid) is derived from Hydnophytum formicarum Jack. The phenolic compounds isolated from the roots were inhibitors of HDAC with an IC50 value of 2.27 mM and also inhibited the activity of AC-I. |
| M11465 | trans-Cinnamic acid | Trans-cinnamic acid was A fungicide with A minimum inhibitory concentration (MIC) of 250 μg/mL against A. sobria (SY-AS1). |
| M11464 | Recombinant Human RANKL (E.coli) | Recombinant Human RANKL is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). |
| M11463 | MI-3 | Mi-3 (Menin-mLL inhibitor 3) is an effective and high affinity menin-MLL inhibitor with IC50 value of 648 nM and Kd value of 201 nM. |
| M11462 | IMM-H007 | Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK). |
| M11461 | Enpatoran hydrochloride | Enpatoran (M5049) Hydrochloride is a potent and orally active inhibitor of TLR7/8, with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. |
| M11460 | ABR-238901 | Abr-238901 is an orally effective S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4(Toll-like receptor 4). Abr-238901 has the potential to be used in myocardial infarction (MI) research. |
| M11459 | ML604440 | ML604440 is a potent, specific and cell-permeable inhibitor of the proteasome β 1I (LMP2) subunit. ML604440 disrupts MHC class I cell surface expression, IL-6 secretion and naive T helper differentiation to 17 T helper cells. ML604440 improves experimental colitis and EAE disease. |
| M11458 | Framycetin | Framycetin (Neomycin B) is an aminoglycoside antibiotic, which is an effective inhibitor of RNase P cleavage activity with Ki of 35 μM. |
| M11457 | Desmopressin Acetate | Desmopressin is a synthetic octapeptide that is an analogue of the human hormone arginine vasopressin and has antidiuretic and procoagulant effects. |
| M11456 | Evixapodlin | Evixapodlin (PD-1/ PD-L1-in 7) is an inhibitor of human PD-1/PD-L1 protein/protein interaction with an IC50 of 0.213 nM. Evixapodlin has anti-cancer and anti-virus properties. |
| M11455 | ACHP Hydrochloride | ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a potent, selective IKK-β Inhibitor with an IC50 of 8.5 nM. |
| M11454 | (-)-DHMEQ | (-) - DHMEQ (Dehydroxymethylepoxyquinomicin) is an effective and selective and irreversible nf-kappa B inhibitors, covalent binding and cysteine residues. (-)-DHMEQ inhibited nuclear NF-κB translocation and showed anti-inflammatory and anticancer activity. |
| M11453 | CCT241533 hydrochloride | CCT241533 Hydrochloride is an effective and selective inhibitor of CHK2, with IC50 and Ki of 3 nM and 1.16 nM, respectively. |
| M11452 | PAT-505 | Pat-505 is a potent, selective, non-competitive, oral autotaxin inhibitor that inhibits autotaxin activity in Hep3B with an IC50 value of 2 nM, 9.7 nM in human blood and 62 nM in mouse plasma, respectively.。 |
| M11451 | Autotaxin modulator 1 | Autotaxin Modulator 1 is an Autotaxin (ATX) inhibitor of Autotaxin (ATX). For details, please refer to compound case 12B in patent literature WO 2014018881 A1. Autotaxin Modulator 1 is expected to be used for demyelination caused by injury or disease, as well as for the study of proliferative diseases such as tumors. |
| M11450 | Chaetoglobosin A | Chaetoglobosin A is an active ingredient in the extract of Penicillium aquamarinium and A member of cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells, thereby inducing cell cycle arrest and inhibiting membrane folds and cell migration. |
| M11449 | AG-024322 | Ag-024322 is a potent ATP-competitive pan-CDK inhibitor that inhibits THE Ki values of CDK1, CDK2, and CDK4 in the 1-3 nM range. Ag-024322 showed broad spectrum antitumor activity and clear target regulation in vivo. Ag-024322 induced apoptosis. |
| M11448 | BLU-945 | Blu-945 is a potent inhibitor of selective epidermal growth factor receptor (EGFR). |
| M11447 | Sunvozertinib | Sunvozertinib (DZD9008) is an effective inhibitor of ErbBs (EGFR, Her2, especially mutants) and BTK. |
| M11446 | NPX800 | NPX800 is an oral HSF1 inhibitor of FIC. NPX800 has the potential to be used in cancer research. |
| M11445 | MRTX0902 | MRTX0902 is an effective SOS1 inhibitor with an IC50 of 46 nM. |
| M11444 | ABBV-CLS-484 | Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity. |
| M11443 | KSQ-4279 | Usp1-in-1 (Formula I), an allosteric INHIBITOR of USP1, has been used IN cancer studies alone or IN combination with PARP inhibition. |
| M11442 | GDC-6036 | Gdc-6036 (compound 17A) is an oral covalently mutated KRAS G12C inhibitor with IC50<0.01 μM against K-Ras G12C. The EC50 of GDC-6036 in K-Ras G12C-alkylated HCC1171 cells was 2 nM. |
| M11441 | CFT7455 | CFT7455 is an orally active inhibitor of zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). CFT7455 is an anticancer agent that binds cereblon E3 ligase with high affinity (Kd 0.9 nM) (WO2022032132A1; Compound 1). |
| M11440 | PC14586 | PC14586 is the First in class oral small molecule p53 Y220C activator to enter the clinical phase, which induces the transformation of p53 protein from mutant to wild-type conformation in a dose-dependent manner. |
| M11439 | NCGC00138783 | NCGC00138783 selectively blocked the interaction of CD47/SIRPα with IC50 of 40 μM. NCGC00138783 does not disrupt the binding of CD47/SIRPα to other receptors. |
| M11438 | zilucoplan | |
| M11437 | SEN177 | |
| M11436 | varoglutamstat | |
| M11435 | ABR-238901 | Abr-238901 is an orally effective S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4(Toll-like receptor 4). Abr-238901 has the potential to be used in myocardial infarction (MI) research. |
| M11434 | Enpatoran | Enpatoran (M5049) is a potent and orally active tlR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. |
| M11433 | PTP1B-IN-1 | Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues. |
| M11432 | Razuprotafib | Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM). |
| M11431 | Poseltinib | Poseltinib is an orally active, selective, irreversible small-molecule Bruton tyrosine kinase (BTK) inhibitor with an IC50 of 1.95 nM and 0.3, 2.3, and 2.4 fold selective action against BMX, TEC, and TXK, respectively. Poseltinib covalently binds to the active site of BTK (cysteine 481 residue) and effectively inhibits B cell receptor (BCR), Fc receptor (FcR), and Toll-like receptor (TLR) mediated signaling. |
| M11430 | Desethyl chloroquine diphosphate | Desethyl chloroquine diphosphate is the main deethyl metabolite of chloroquine. Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Desethyl Chloroquine diphosphate has anti-plasmodium activity. |
| M11429 | H3B-8800 | An oral RNA splicing regulator targeting spliceosomal SF3b complex. By inhibiting the action of SF3b complex, tumor cells carrying spliceosomal mutations are more effectively killed. |
| M11428 | LSN3318839 | LSN3318839 is an orally active allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R). |
| M11427 | RM-018 | RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C. |
| M11426 | AM404 | AM404 is an endocannabinoid reuptake inhibitor that can block anandamide transport with IC50 values in the low mole range. The isolated rat hepatic artery was constricted by norepinephrine and relaxed by AM404. PEC50 value was 7.4 (corresponding EC50 value was 0.04 µM). It has neuroprotective effects [2]. |
| M11425 | Valbenazine tosylate | Valbenazine Tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with Ki of 110-190 nM. |
| M11424 | Carotegrast methyl | Carotegrast Methyl (AJM300) is an orally effective and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast Methyl, is a specific dual α4β1/α4β7 integrin antagonist. Carotegrast Methyl prevents colitis in mice. |
| M11423 | RS 09 | RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment. |
| M11422 | Sodium copper chlorophyllin B | Sodium Copper ch-ch-lin B has antiviral activity against both influenza virus and HIV with an IC50s of 50 to 100 μM. |
| M11421 | AUNP-12 TFA | Aunp-12 (NP-12) TFA is a peptide antagonist of the PD-1 signaling pathway, which has an equivalent antagonistic effect on PD-L1 and PD-L2 in terms of inhibiting lymphocyte proliferation and effector function. Aunp-12 TFA has immune-activating effect and good anti-tumor activity, which has the potential to better study immune-related adverse events (irAEs). |
| M11420 | MYCi975 | MYCi975 (Nuc-0200975) is an orally active MYC inhibitor that disrupts MYC/MAX interactions, promotes MYC T58 phosphorylation and MYC degradation, and impairs myC-driven gene expression. MYCi975 (NUC-0200975) has strong anti-tumor effect and good tolerance, increasing tumor immune cell infiltration and enhancing tumor sensitivity against PD1 immune studies. |
| M11419 | Trilaciclib hydrochloride | Trilaciclib hydrochloride (G1T28 Hydrochloride) is an inhibitor of CDK4/6 with IC50 values of 1 nM and 4 nM for CDK4 and CDK6, respectively. |
| M11418 | SAR-020106 | Sar-020106 is an ATP-competitive and selective CHK1 inhibitor with an IC50 of 13.3 nM. Sar-020106 has good selectivity to CHK2. Sar-020106 increased cell lethality of Gemcitabine and SN38 by 3.0 to 29 times in a p53-dependent manner in several colon cancer cell lines. Sar-020106 can enhance antitumor activity by selecting anticancer drugs. |
| M11417 | (S)-Sunvozertinib | (S)-Sunvozertinib ((S)-DZD9008) is the S-enantiomer of Sunvozertinib, EGFR exon 20 NPH and ASV insertion, EGFR L858R/T790M mutation and Her2 exon 20 YVMA insertion (IC50 was 51.2 nM, 51.9 nM, 1 nM and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK. |
| M11416 | FHD-286 | FIC oral BAF chromosomal remodeling complex allosteric inhibitors (via BRG1 and BRM ATPase inhibition) can be used to study metastatic melanoma and advanced hematologic tumors. |
| M11415 | (Rac)-JBJ-04-125-02 | (Rac)-JBJ-04-125-02 is a racemate of JBJ-04-125-02, which is a potent, selectively mutated, allosteric and oral active EGFR inhibitor. The IC50 of EGFRL858R/T790M was 0.26 nM. |
| M11414 | Hyodeoxycholic acid | Hyodeoxycholic acid is a secondary bile acid formed by intestinal flora in the small intestine and is an agonist of TGR5 (GPCR19). In CHO cells, the EC50 value is 31.6 µM. |
| M11413 | Antimony Potassium | |
| M11412 | Congo Red | Congo Red is an azo dye. Congo Red binding has been widely used in the determination of amyloid in tissue sections. |
| M11411 | 1V209 | 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity. |
| M11410 | Polyinosinic-polycytidylic acid sodium | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA that is an agonist of TLR3 and retinoic acid-inducible gene I receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, change the tumor microenvironment, and directly trigger apoptosis in cancer cells. |
| M11409 | Polyinosinic-polycytidylic acid | Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Polyinosinic-polycytidylic acid is present in some viruses and is therefore commonly used to mimic the action of extracellular dsRNA. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M11407 | FSL-1 TFA | Fsl-1 TFA is a bacteria-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. Fsl-1 TFA induces mMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways. |
| M11406 | Berotralstat | Berotralstat (BCX7353) was a second generation plasma kallikrein inhibitor with low toxicity and high specificity, and was used for the diagnosis of hereditary angioedema (HAE). Berotralstat works by blocking the enzyme activity of plasma Kallikrein that releases bradykinin, a major biological peptide that promotes swelling and pain associated with HAE attacks. |
| M11405 | Inavolisib | Gdc-0077 (RG6114) is an effective, oral, selective PI3Kα inhibitor (IC50=0.038 nM). Gdc-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting phosphorylation of PIP2 to PIP3. Compared with wild-type PI3Kα, GDC-0077 (RG6114) showed higher selectivity against mutants. |
| M11404 | EMD638683 | EMD638683 is a highly selective SGK1 inhibitor with an IC50 value of 3 μM. |
| M11403 | A939572 | A939572 is a potent, orally active stearyl CoA desaturase 1 SCD1 inhibitor that acts on mSCD1 and hSCD1 with IC50 <4 nM and 37 nM, respectively. |
| M11402 | TCH-165 | Tch-165 is a small molecule modulator of proteasome assembly that increases 20S levels and promotes 20S-mediated protein degradation. |
| M11401 | Sodium lauryl sulfate | Sodium dodecyl sulfate (SDS) is a kind of anionic surfactant, which is the first reported proteasome agonist, and has the characteristics of low concentration promotion and high concentration inhibition. |
| M11400 | Valbenazine | Valbenazine (NBI-98854) is a vesicular monoamine transporter-2 (VMAT2) inhibitor with a Ki of 110-190 nM. |
| M11399 | AZD9977 | AZD9977 is a potent, selective, and orally active modulator of corticosteroid receptors (MR). AZD9977 was studied for heart failure and chronic kidney disease. |
| M11398 | Vasopressin | Vasopressin is a cyclic nine-peptide synthesized in the hypothalamus center. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by enhancing the stimulating effect of corticotropin-releasing factor. Vasopressin can also act as a neurotransmitter, acting by binding to specific G-protein-coupled receptors. |
| M11397 | D[LEU4,LYS8]-VP TFA | D[LEU4,LYS8]-VP TFA is a selective agonist of vasopressin V1b receptors, with Ki values of 0.16 nM, 0.52 nM and 1.38 nM for rat, human and mouse V1b receptors, respectively. D[LEU4,LYS8]-VP TFA showed weak antidiuretic, vasopressor and oxytocin activity in vitro. |
| M11396 | Terlipressin acetate | Terlipressin acetate is a vasopressin analogue and a highly selective vasopressin V1 receptor agonist that reduces visceral blood flow and portal vein pressure and controls acute varicose rupture bleeding. Terlipressin acetate has anti-inflammatory and antioxidant effects and can be used to study hepatorenal syndrome and norepinephrine-resistant septic shock. |
| M11395 | Lixivaptan | Lixivaptan (VPA-985, WAY-VPA 985) is an orally active, selective vasopressin receptor V2 antagonist with IC50 values of 1.2 nM in humans and 2.3 nM in rats. |
| M11394 | Felypressin | Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 (Vasopressin 1) agonist. Felypressin is widely used in dental surgery. |
| M11393 | RG7713 | RG7713 (RO5028442) is a highly effective and selective brain-osmotic vasopressin 1A (V1a) receptor antagonist with Ki values of 1 nM (hV1a) and 39 nM (mV1a). |
| M11392 | Ganoderic acid C1 | Ganoderic acid C1, a natural product isolated from G. lucidum, inhibits the production of TNF-α in mouse macrophages. |
| M11390 | Recombinant Human 4-1BB Protein | Protein sequence: DNA sequence encoding human 4-1BB (UniProtKB/ Swiss-PROt: Q07011.1) expressed with His tag at the C-terminal Bioactivity: 4-1BB, also known as CD137, is a member of the tumor necrosis factor receptor superfamily 9 (TNFRSF9) induced by lymphocyte activation (ILA), and is a costimulatory molecule of the tumor necrosis factor receptor superfamily. |
| M11389 | Anti-human CD3/CD28 beads for T cell | Bioactivity: AMMS® CD3/CD28 mab conjugated magnetic beads are mainly used for isolation, activation and in vitro amplification of human T cells. |
| M11388 | Anti-human CD137 mAb | Biological activity: CD137(also known as 4-1BB) is an inducible cell surface receptor, a member of the tumornecrosis factor receptor (TNFR) superfamily. |
| M11387 | Anti-human CD20 mAb | Biological activity: CD20 is a specific marker molecule on the surface of B lymphocytes. It is expressed on more than 95% of normal or malignant B lymphocytes and is not expressed in hematopoietic stem cells, progenitor cells, and other normal tissues. |
| M11385 | Anti-human PD-1 mAb | Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body. |
| M11384 | Anti-human HER-2 mAb | Biological activity: HER2, also known as ErbB2, is a member of the human epidermal growth factor receptor family and plays an important role in signal transduction. |
| M11383 | Anti-human CD16 mAb | Bioactivity: CD16 is FcγR ⅲ, a glycoprotein with a molecular weight of 50-70kD, a member of Ig superfamily, known to be involved in antigen-dependent cytotoxicity (ADCC). The most significant feature of CD16 is that the cleavage triggered by membrane receptors is performed by NK cells. |
| M11382 | Recombined human IL-15 MAX | Protein sequence: DNA encoding human IL-10 (P40933) Bioactivity: Cell proliferation was measured with MO7e human megakaryocytic leukemia cells with an ED50 of 7-28 ng/mL |
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