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Cat.No.  Name Information
M54739 Recombinant Human ICA 512/PTPRN Protein (80AA&94AA, E.coli, N-6His) ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions.
M54738 Recombinant Human ICA 512/PTPRN Protein (293AA, E.coli, N-6His) ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions.
M54737 Recombinant Human GAD67 Protein (Baculovirus-Insect, C-His) GAD67 (GAD1) is a member of thegroup II decarboxylase family. GAD67 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker.
M54736 hFSH-β-(33-53) TFA hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells.
M54734 SLK/STK10-IN-1 SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.
M54732 Recombinant Human GAS6 Protein (Mammalian, C-6His) GAS6 (Growth arrest-specific protein 6) also known as AXL receptor tyrosine kinase ligand, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest.
M54731 Recombinant Mouse GAS6 Protein (HEK293, C-His) GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells.
M54730 INV-347 INV-347 is a CB1R inverse agonist that can be used in studies related to obesity.
M54728 Kdo2-Lipid A ammonium Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2.
M54727 Xylan Xylan is a polypentasaccharide and a hemicellulose component found extensively in plant cell walls.Xylan consists mainly of cellulose-linked β-D-xylose units.
M54726 Chitosan (MW 150000) Chitosan (MW 150000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 150000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and anti-oxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection.
M54725 Chitosan (MW 30000) Chitosan (MW 30000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 30,000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection.
M54724 Trimethylamine N-oxide dihydrate Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients.Trimethylamine N-oxide dihydrate induces inflammation by activating ROS/NLRP3 inflammasome, and also accelerates fibroblast differentiation and induces cardiac fibrosis by activating TGF-β/smad2 signaling pathway. In addition, Trimethylamine N-oxide dihydrate induces tumor cell pyroptosis and enhances CD8+ T cell-mediated antitumor responses in triple-negative breast cancer.
M54722 Fluoflavine Fluoflavine is a selective NOX1 inhibitor with an IC50 value of 90 nM.Fluoflavine is >100 times more selective for NOX1 than NOX2, NOX3, NOX4, and has an IC50 >10 μM for all of them.Fluoflavine was shown to be a selective inhibitor of NOX1 with an IC50 of 360 nM in HEK293 cells.
M54721 A 83-01 sodium A 83-01 sodium is a potent inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7, inhibiting ALK5, ALK4, and ALK7-induced transcription with IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively.
M54719 O4I3 O4I3 is a potent and selective inhibitor of the KDM5A (JARID1A) isoform of H3K4 demethylase, with an IC50 value of 0.15 nM.O4I3 effectively induces OCT4 expression and enhances OSKM-induced pluripotent stem cell reprogramming efficiency (50 nM) of human primary fibroblasts by preventing KDM5A from interfering with the enrichment of H3K4Me3 on the OCT4 promoter. iPSC) reprogramming efficiency (50 nM).
M54718 PP405 PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia.
M54717 GYM329 GYM329 is a monoclonal antibody that binds to and inhibits activation of the muscle growth inhibitor (myostatin) precursor protein target.
M54716 Trontinemab Trontinemab is a bispecific human IgG1-κ antibody that targets amyloid β A4 precursor protein (APP) and transferrin receptor (TFRC).Trontinemab may be used in Alzheimer's disease-related studies.
M54715 ZK53 ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells.
M54714 BAY 1892005 BAY 1892005, a p53 protein modulator, is active on p53 condensates and does not lead to mutant p53 reactivation.
M54713 ZH8667 ZH8667 is a trace amine-associated receptor 1 (TAAR1)–Gs agonist.
M54712 PF-07224826 PF-07224826 is a CDK2/4/6 inhibitor.
M54711 INCB123667 INCB123667 is a CDK2 inhibitor.
M54710 Senexin B Senexin B is a potent, orally active CDK8/19 inhibitor with Kd values of 140 nM and 80 nM for CDK8 and CDK19, respectively.
M54709 Q901 Q901 is a CDK7 inhibitor for tumor-related studies.
M54708 NUV-422 NUV-422 is a CDK2/4/6 inhibitor that can be used in studies related to malignant gliomas.
M54707 INX-315 INX-315 is an orally potent and selective CDK2 inhibitor that induces cell cycle arrest in G1 phase. INX-315 also induces CDK2 substrate phosphorylation and inhibits tumor growth in a dose-dependent manner in a xenograft mouse model.INX-315 can be used in cancer-related studies.
M54706 GTAEXS-617 GTAEXS-617 is a highly selective small molecule non-covalent CDK7 inhibitor.
M54705 BLU-222 BLU-222 is an oral, potent, selective CDK2 inhibitor.
M54704 AZD-8421 AZD-8421 can target CDK2 and can be used in tumor-related studies.
M54703 BBT-207 BBT-207 is a reversible, mutant-specific EGFR inhibitor with antitumor activity.
M54702 VRN-11 VRN-11 is an EGFR C797S inhibitor.
M54701 TRX-221 TRX-221 is an EGFR C797S inhibitor.
M54700 TAS-3351 TAS-3351 is an EGFR C797S inhibitor.
M54699 Recombinant Human Lactoferrin/LTF Protein (Mammalian, C-6His) Lactoferrin (LTF) is a major iron-binding protein in exocrine fluid and controls the level of free iron in the blood and external secretions. It exhibits multiple antibacterial effects by chelating iron and disrupting bacterial membranes.
M54698 LY-3076226 LY-3076226 is an antibody drug coupling (ADC) with a cleavable linker targeting FGFR2.
M54697 Aprutumab ixadotin Aprutumab ixadotin is an antibody drug coupling (ADC) with a non-cleavable linker that targets FGFR2.
M54696 DGY-09-192 DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells.
M54695 Kendomycin Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist.
M54693 Ceftobiprole Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA.
M54692 MM120 MM120 is a synthetic tryptamine that is also a partial agonist at the 5-hydroxytryptamine 2A (5-HT2A) receptor. It can be used in studies related to GAD and attention deficit hyperactivity disorder (ADHD).
M54691 Leuco methylthioninium Leuco methylthioninium is a tau protein aggregation inhibitor that can be used in studies related to Alzheimer's disease (AD).
M54690 HB0017 HB0017 is a monoclonal antibody that targets interleukin-17 (IL-17) and selectively binds IL-17A, thereby preventing IL-1717A from binding to its receptor.
M54689 Astragalus Polysacharin (70%) Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes.
M54688 Pegtibatinase Pegtibatinase is a cystathionine beta synthase (CBS) regulator that can be used in studies related to homocystinuria.
M54687 SQLE-IN-1 SQLE-IN-1 is a squalene cyclooxygenase (SQLE) inhibitor and inhibits the proliferation and migration of Huh7 cells. In addition, SQLE-IN-1 inhibits cellular cholesterol production, increases PTEN expression, and inhibits PI3K and AKT expression.
M54686 Amycretin Amycretin is a novel, potentially first-in-class, long-acting co-agonist of GLP-1 and the amyloid receptor (AMYR) for obesity-related studies.
M54685 IRAK4-IN-22 IRAK4-IN-22 is an orally potent and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively.In addition, IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.10 µM), which may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis).
M54684 HS271 HS271 is an orally potent and selective IRAK4 inhibitor with an IC50 value of 7.2 μM. In addition, HS271 has superior in vitro enzymatic and cellular activities.
M54683 PROTAC IRAK4 degrader-3 PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC.
M54682 IRAK inhibitor 4 (trans) IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4 and a potent inhibitor of IRAK4.
M54681 IRAK4-IN-21 IRAK4-IN-21 is an orally potent, selective, and potent IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively.IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.17 µM) and may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis).
M54680 Larotinib mesylate hydrate Larotinib mesylate hydrate is a potent, broad-spectrum, orally active tyrosine kinase inhibitor (TKI) that primarily targets EGFR with an IC50 of 0.6 nM.
M54679 IRAK-4 protein kinase inhibitor 2 IRAK-4 protein kinase inhibitor 2 is a potent interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) inhibitor with an IC50 value of 4 μM.IRAK-4 protein kinase inhibitor 2 can be used in the study of inflammatory and immune-related diseases.
M54678 KTX-582 KTX-582 is a potent IRAK4 degrader with a DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively.In addition, KTX-582 induces apoptosis in MYD88MT DLBCL cells and tumor regression in vivo in a lymphoma model.
M54677 KTX-951 KTX-951 is a PROTAC (DC50= 18 nM) that targets the degradation of interleukin-1 receptor-associated kinase 4 (IRAK4) and exhibits promising anticancer activity.
M54676 PF-06426779 PF-06426779 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 value of 0.3 nM.
M54675 Edecesertib Edecesertib is a selective, orally active IRAK-4 inhibitor. In addition, Edecesertib has anti-inflammatory activity and may be used in studies related to rheumatoid arthritis (RA) and lupus erythematosus (LE).
M54674 IRAK inhibitor 2 IRAK inhibitor 2 is an interleukin-1 receptor-related kinase 4 (IRAK4) inhibitor.
M54673 JH-X-119-01 hydrochloride JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1), which also ameliorates LPS-induced sepsis in mice.
M54672 Bovine Serum Albumin (Fatty Acid & IgG Free) BSA is a highly purified, lyophilized albumin, suitable for Westerns, enzyme systems, protein standards, hybridizations and as a protease-sensitive immunoassays. It is also perfectly suitable as a nutrient in cell culture media, with low interference and backgrounds and is ideal for most standard molecular biology experiments.
M54671 BTX-6654 BTX-6654 is a targeted and specific cerebellar-based bifunctional SOS1 PROTAC degrader.BTX-6654 reduces the downstream signaling markers pERK and pS6 and displays antiproliferative activity in a wide range of KRAS-mutant cells.
M54670 JTE-151 JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases.
M54669 TL-925 TL-925 is a potentially first-in-class Bruton's tyrosine kinase (BTK) inhibitor that targets mast cell-mediated ocular inflammation and hypersensitivity and can be used in studies related to dry eye.
M54668 A-005 A-005 is a potentially first-in-class, brain-penetrating TYK2 allosteric inhibitor for studies related to neuroinflammatory and neurodegenerative diseases.
M54667 UCCF-853 UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator.
M54666 (R)-Posenacaftor sodium (R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF).
M54664 (R)-Olacaftor (R)-Olacaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator that can be used in cystic fibrosis (CF) related studies.
M54662 CFTR corrector 9 CFTR corrector 9 is a cystic fibrosis transmembrane conductance regulator protein (CFTR) modulator for cystic fibrosis (CF) and other CFTR-related diseases.
M54661 CFTR corrector 8 CFTR corrector 8 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and can be used in cystic fibrosis related studies.
M54660 VRT-532 VRT-532 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) that enhances channel activity in G551D-CFTR and intrinsic ATPase activity in G551D-CFTR.VRT-532 can be used in cystic fibrosis related studies.
M54659 (R)-Elexacaftor (R)-Elexacaftor is an enantiomer of Elexacaftor and a corrector of cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 value of 0.29 μM for CFTR dF508.
M54658 Ivacaftor hydrate Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies.
M54657 CFTR corrector 6 CFTR corrector 6 is a potent cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis (CF) and other CFTR-related diseases.
M54656 NJH-2-056 NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking EN523, a recruitment factor for OTUB1, to lumacaftor, a CFTR chaperone protein.NJH-2-056 can be used in cystic fibrosis-related studies.
M54655 K41498 TFA K41498 TFA is an antisauvagine-30 (aSvg-30) analog and a strongly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM, and 425 nM for human CRF2α, CRF2β, and CRF1 receptors, respectively.K41498 TFA inhibits sauvagine-stimulated cAMP accumulation in hCRF2α/hCRF2β expressing cells. K41498 TFA can be used in hypotension studies.
M54654 Crinecerfont hydrochloride Crinecerfont hydrochloride is a potent, orally active, nonpeptide CRF1 receptor antagonist for use in congenital adrenal hyperplasia (CAH) studies. In addition, Crinecerfont hydrochloride is a click chemistry. It contains an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety.
M54653 SRI-37240 SRI-37240 is a potent inhibitor of premature termination codons (PTCs) that suppresses nonsense mutations in CFTR. In HEK293T cells, SRI-37240 alters the cellular translation termination of PTCs. When used in combination with G418, SRI-37240 also restores CFTR function in primary bronchial epithelial cells.
M54652 Bamocaftor Bamocaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that restores F508del-CFTR protein function.Bamocaftor can be used in cystic fibrosis-related studies.
M54651 Cavosonstat Cavosonstat is an orally active nitrosoglutathione reductase (GSNOR) inhibitor. In addition, Cavosonstat is a CFTR stabilizer and can be used in cystic fibrosis studies.
M54649 Navocaftor Navocaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator.
M54648 SRI-41315 SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity.
M54647 (R)-Vanzacaftor (R)-Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR).
M54646 Astressin 2B TFA Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of 1.3 and > 500 nM for CRF2 and CRF1, respectively.
M54645 SION-109 SION-109 is a transmembrane conductance regulator (CFTR) modulator that targets the interface of CFTR nucleotide-binding domain 1 (NBD1) interaction with the CFTR intracellular loop 4 (ICL4) protein domain.
M54644 SION-719 SION-719 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein.
M54643 SION-451 SION-451 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein.
M54642 Scalaradial Scalaradial is a marine-derived natural product that modulates protein tyrosine kinase receptor-mediated signaling pathways.
M54641 Murrayafoline A Murrayafoline A is a carbazole alkaloid that enhances calcium inward flow through L-type calcium channels.Murrayafoline A can be used for related research in the life sciences.
M54640 Showdomycin Showdomycin is an antibiotic that is induced by IM-2 in Streptomyces.
M54639 Shizukaol A Shizukaol A is a sesquiterpene dimerizable from Chloranthus japonicas.
M54638 Aspulvinone O Aspulvinone O is a natural inhibitor of aspartate aminotransferase 1 (GOT1) and inhibits the growth of pancreatic ductal adenocarcinoma cells by interfering with glutamine metabolism.
M54637 Recombinant Mouse Thioredoxin/SASP Protein (E. coli) Thioredoxin/SASP Protein participates in a variety of redox reactions and can use its active dithiol center for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchanges and plays a key role in the S-nitrosylation of cysteine residues in response to intracellular nitric oxide.
M54636 Recombinant Human Thioredoxin/SASP Protein (E.coli, N-6His) Recombinant Human Thioredoxin/SASP Protein participates in a variety of redox reactions and can use its active dithiol center for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchanges and plays a key role in the S-nitrosylation of cysteine residues in response to intracellular nitric oxide.
M54634 FM1-43 FM1-43 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM1-43 is widely used in endocytic and exospic membrane structure markers.
M54633 FDW028 FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway.
M54632 XPW1 XPW1 is a potent and selective CDK9 inhibitor with excellent activity against clear cell renal cell carcinoma (ccRCC) and low toxicity.
M54630 DHODH-IN-13 DHODH-IN-13 is a hydroxyfurazan analog of A771726 and a dihydroorotic acid dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for hepatic DHODH in rats.DHODH-IN-13 can be used in rheumatoid arthritis-related studies.
M54629 DHODH-IN-12 DHODH-IN-12 is a Leflunomide derivative and a weak inhibitor of dihydroorotic acid dehydrogenase (DHODH), with a pKa of 5.07.



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