| Cat.No. | Name | Information |
|---|---|---|
| M40956 | Olezarsen | Olezarsen, an N-acetylgalactosamine (GalNAc)-suffixed antisense oligonucleotide (ASO) targeting hepatic APOC3 mRNA, inhibits the production of apolipoprotein C-III (apoC-III) and can be used in studies related to familial celiac sprue syndrome (FCS). |
| M40955 | Vutrisiran | Vutrisiran is a liver-directed small interfering RNA (siRNA) that targets transthyretin protein (TTR) mRNA and can be used in TTR-mediated amyloidosis studies. |
| M40954 | Lumasiran | Lumasiran is a siRNA compound that reduces hepatic oxalate production by targeting ethanoic acid oxidase. |
| M40953 | Givosiran | Givosiran is a small interfering RNA that targets hepatic aminofibrillar synthase 1 (ALAS1) messenger RNA, down-regulates ALAS1 mRNA, and prevents the accumulation of neurotoxic α-aminofibrillar acids and porphyrins, which can be used in porphyria-related studies. |
| M40952 | Patisiran | Patisiran is a small double-stranded interfering RNA that targets sequences within the Transthyretin (TTR) messenger RNA and specifically inhibits hepatic synthesis of mutant and wild-type TTR. It can be used to study hereditary TTR amyloidosis. |
| M40951 | Viltolarsen | Viltolarsen is a phosphorodiamidomorpholine antisense oligonucleotide that targets splicing of exon 53 of the myotonic dystrophy protein gene and can be used in the study of Duchenne muscular dystrophy (DMD). |
| M40950 | Golodirsen | Golodirsen is a phosphodiesteric morpholino oligomer (PMO) that specifically targets exon 53 of the pre-protein mRNA of myotonic dystrophy protein culture proteins, and can be used in studies related to Duchenne muscular dystrophy (DMD). |
| M40949 | Eteplirsen | Eteplirsen is a synthetic antisense oligonucleotide that can be used in studies related to Duchenne muscular dystrophy (DMD). |
| M40948 | Volanesorsen | Volanesorsen is an antisense oligonucleotide that targets apolipoprotein C-III (APOC3) mRNA and can be used in studies related to familial celiac disease syndrome. |
| M40947 | Inotersen | Inotersen is an antisense oligonucleotide that inhibits the production of the hepatic transthyretin (TTR) protein. It can be used in studies related to TTR-mediated amyloidosis. |
| M40946 | Mipomersen | Mipomersen is a 20-base gapmer (antisense oligonucleotide) that inhibits apolipoprotein B (apoB) and lowers LDL, which can be used in studies related to hyperlipidemia. In addition, Mipomersen has anti-HCV activity. |
| M40945 | Pegaptanib Sodium | Pegaptanib Sodium is an RNA aptamer targeting vascular endothelial growth factor (VEGF)-165, a molecule of oligonucleotides chemically linked to polyethylene glycol (PEG), which can be used in studies related to neovascular age-related macular degeneration (AMD). |
| M40944 | Fomivirsen | Fomivirsen is a phosphorothioate oligonucleotide derivative that binds to and degrades the mRNA of the CMV immediate-early 2 protein, thereby inhibiting viral proliferation, and can be used in studies related to cytomegalovirus retinitis (CMV). |
| M40943 | INV-202 | INV-202 is an orally active type 1 cannabinoid receptor (CB1) blocker that blocks the receptor protein CB1 in peripheral tissues such as adipose tissue, gastrointestinal tract, kidneys, liver, pancreas, muscle, and lungs, and can be used in studies related to obesity. |
| M40942 | Obicetrapib | Obicetrapib is a selective, orally active cholesterol transporter protein (CETP) inhibitor that blocks the function of CETP and significantly reduces LDL-C while significantly increasing HDL-C levels, and may be used in studies related to atherosclerosis and Alzheimer's disease (AD). |
| M40941 | Guanadrel | Guanadrel is an orally active, spiroketal postganglionic adrenergic inhibitor containing a spirocyclic moiety in its structure, which may be used in studies related to hypertension. |
| M40940 | Pinatuzumab vedotin | Pinatuzumab vedotin is an antibody-drug coupling (ADC) targeting CD22 containing the microtubule inhibitor monomethylauristatin E (MMAE) for studies related to diffuse large B-cell lymphoma. |
| M40937 | Suciraslimab | Suciraslimab is a monoclonal antibody against the B-cell target CD22, which can help CD22 change from cis-binding mode to trans-binding and form a stable CD22 trans-binding structure, thus restoring B-cell tolerance to its own antigens and inhibiting B-cells from a series of related immune responses to attack its own organism. |
| M40933 | BGB-30813 | BGB-30813 is a DGKζ inhibitor that can be used in studies related to solid tumors.DGKζ is a member of the diacylglycerol kinase (DGK) family of phosphatidylglycerol kinases, which plays an important role in the regulation of a variety of cell signaling pathways. |
| M40932 | GDC-6599 | GDC-6599 is a first-in-class, orally effective TRPA1 inhibitor for studies related to chronic cough and asthma. |
| M40931 | ORM-5029 | ORM-5029 is a HER2/HER3-specific dual-targeted antibody degrader coupling (AnDC) for studies related to HER2-positive breast cancer. |
| M40930 | CC-91633 | CC-91633 is a Cereblon (CRBN) modulator for studies related to acute myeloid leukemia and myelodysplastic syndromes. |
| M40929 | CC-11006 | CC-11006 is a Cereblon (CRBN) modulator for studies related to amyotrophic lateral sclerosis and myelodysplastic syndromes. |
| M40928 | (+)-Dipentene | (+)-Dipentene is a naturally occurring substance found in a variety of plant essential oils with anti-microbial, anti-oxidant, anti-carcinogenic and anti-inflammatory activities. |
| M40927 | Recombinant Mouse IL-1RL2 Protein (Mammalian, C-6His) | Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family. IL1RL2 is the receptor for interleukin-36. Recombinant Mouse Interleukin-1 Receptor-like 2 expressed the target gene encoding Asp22-Arg338(Ala158Val) with a 6His tag at the C-terminus. |
| M40926 | Recombinant Human/Mouse/Rat GDF-11 Protein (Mammalian) | Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. |
| M40924 | Recombinant Human IL31RA Protein (HEK293, C-hFc) | The recombinant human IL31RA consists 735 amino acids and predicts a molecular mass of 83.5 kDa. A DNA sequence encoding the human IL31RA (Met1-Ser516) was expressed with the Fc region of human IgG1 at the C-terminus. |
| M40923 | Recombinant Human IL31RA Protein (HEK293, C-His) | The recombinant human IL31RA consists 508 amino acids and predicts a molecular mass of 58.2 kDa. A DNA sequence encoding the human IL31RA (Met1-Ser516) was expressed with a polyhistidine tag at the C-terminus. |
| M40922 | PEG20000 | Polyethylene glycol 20000 (PEG 20000) is a polymer formed by condensation reaction of ethylene oxide and water. Polyethylene glycol is used for the isolation of plasmid DNA and the precipitation of phage. |
| M40921 | Recombinant Human IL-1β Protein (CHO) | Interleukin 1 beta (IL-1β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. |
| M40919 | Recombinant Human GSTM2 Protein (E. coli, His Tag) | Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. A DNA sequence encoding the native human GSTM2 (Met 1-Lys 218) was expressed, with a polyhistide tag at the N-terminus. |
| M40917 | Rivulariapeptolides 1121 | Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively. |
| M40916 | Rivulariapeptolides 1185 | Rivulariapeptolides 1185 is a potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM, and 55.26 nM for tryptic coagulase, elastase, and proteinase K, respectively. |
| M40915 | Rivulariapeptolides 988 | Rivulariapeptolides 988 is a potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for tryptic coagulase, elastase and proteinase K, respectively. |
| M40914 | Rivulariapeptolides 1155 | Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. |
| M40913 | Helicin | Helicin is a natural product derived from the Rosaceae family of plants and is also a moderate syrB inducer. |
| M40912 | Tricaprilin | Tricaprilin is an orally active medium chain triglyceride that improves mitochondrial metabolism by inducing a ketosis state. It can be used in studies related to Alzheimer's disease (AD). |
| M40911 | Octahydroaminoacridine succinate | Octahydroaminoacridine succinate is a Tacrine analog and a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It may be used in studies related to Alzheimer's disease (AD). |
| M40910 | Triolex | Triolex is an ERK as well as nuclear factor κB inhibitor inhibitor that selectively inhibits the inflammatory ERK signaling pathway and may reduce neuroinflammation by inhibiting inflammation-driven insulin resistance and major pathological inflammatory cascades. It can be used in studies related to Alzheimer's disease (AD). |
| M40908 | Fosgonimeton Ammonium | Fosgonimeton Ammonium is a modulator of HGF/MET that enhances HGF/MET signaling pathway activity, reverses synaptic disconnection and neuronal loss, and may be used in Alzheimer's disease (AD)-related studies. |
| M40907 | Lactoferrin | Lactoferrin is a 75 to 80 kDa non-heme iron-binding glycoprotein that regulates iron homeostasis in the body, regulates bone marrow cell production, promotes cell growth, regulates immune function, and has broad-spectrum antibacterial, antiviral, and antitumor activities. |
| M40906 | N-Methylbenzylamine | N-Methylbenzylamine, a small molecule inhibitor targeting phosphodiesterase-5 (PDE-5), exerts neuroprotective effects by inhibiting neuronal apoptosis and restoring synaptic plasticity, and can be used in studies related to Alzheimer's disease (AD). |
| M40904 | ODN TTAGGG | ODN TTAGGG is an inhibitory oligodeoxynucleotide (ODN) as well as a TLR9, AIM2 and cGAS antagonist with immunosuppressive activity, which inhibits the activation of the AIM2 inflammasome by competing with DNA, as well as the activation of cGAS. It can be used in the study of autoimmune diseases such as lupus erythematosus. Sequence: 5'-T-T-T-A-G-G-G-T-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-3'. |
| M40903 | DSPE-PEG2000-Mannose | DSPE-PEG2000-Mannose is a functional molecule commonly used in biomedical research for studies related to nanodrug delivery systems or cellular recognition. |
| M40901 | Recombinant Human LBP (Mammalian, C-6His) | Lipopolysaccharide binding protein (LBP) is a plasma protein, it is involved in the acute-phase immunologic response to gram-negative bacterial infections. |
| M40899 | LOXO-435 | LOXO-435 is a highly selective fibroblast growth factor receptor-3 (FGFR3) antagonist that can be used in a variety of tumor-related studies. |
| M40898 | Thioanisole | Thioanisole is used as a raw material for the synthesis of antibiotics and insecticides. |
| M40897 | HBTU | HBTU is a coupling agent for peptide synthesis with low racemization, simple reaction conditions and short reaction times. |
| M40896 | 2,2,2-Trifluoroethanol | 2,2,2-Trifluoroethanol is an important aliphatic fluorinated intermediate that serves as a polymerization and solvation medium to maintain peptide integrity and functionality during encapsulation and release. |
| M40895 | Potassium carbonate | Potassium carbonate is a common potassium salt as well as a common potassium fertilizer. |
| M40894 | Sodium sulfate | Sodium sulfate is a ubiquitous salt used to enhance the binding of phenolics to sulfate and can be used in studies related to hypercalcemia. |
| M40893 | Ethyl chloroacetate | Ethyl chloroacetate is used as a raw material for the preparation of the insecticide azoxystrobin and the herbicide ethyl chlormequat, as well as for the synthesis of 5-fluorouracil (5-FU). |
| M40892 | Acetaldehyde | Acetaldehyde is a TRP anchor protein 1 (TRPA1) agonist that is converted to non-toxic acetic acid by acetaldehyde dehydrogenase (ALDH). |
| M40891 | Chloranil | Chloranil is a fungicide that can be used to treat seeds and bulbs of crops against fungal diseases. |
| M40890 | Di-tert-butyl dicarbonate | Di-tert-butyl dicarbonate is a carboxylic acid ester derivative used for amino protection of amino acids, as well as in pharmaceuticals, protein, and peptide synthesis. |
| M40889 | Ethyl cyanoglyoxylate-2-oxime | Ethyl cyanoglyoxylate-2-oxime is used as a raw material for insecticides, fungicides, and other pesticides to control pests and diseases in a wide variety of crops. |
| M40888 | HOAT | HOAT inhibits the production of racemization in peptide condensation and can also be used in fragment condensation. |
| M40887 | 6-Chloro-1-hydroxibenzotriazol | 6-Chloro-1-hydroxibenzotriazol is a non-toxic reagent that inhibits peptide-coupled racemization and is also used in the preparation of fusidic acid A cyclic aminothiazole derivatives. |
| M40886 | Human serum albumin | Human serum albumin is a protein found in human plasma. Its non-glycosylated, single-chain polypeptide contains 585 amino acids, has a molecular weight of 66 kD, transports fatty acids, bile pigments, amino acids, and steroid hormones, and serves as an excipient, stabilizer, and encapsulant. |
| M40885 | NOTA-bis(tBu)ester | NOTA-bis(tBu)ester is a chelating agent. |
| M40884 | Fmoc-1,4-trans-achc-oh | Fmoc-1,4-trans-achc-oh |
| M40883 | 3-Mercapto-1-propanol | 3-Mercapto-1-propanol can be used for the preparation of hydrophilic self-assembled monolayers and as a non-marking linker molecule for chemical and enzymatic synthesis of oligosaccharides. |
| M40882 | tert-Butyl methyl ether | tert-Butyl methyl ether is an extraction solvent that promotes the production of reactive oxygen species and can be used for the extraction of tissue lipids. |
| M40881 | Cuprous iodide | Cuprous iodide is a commonly used cuprous halide used as an animal feed additive. |
| M40880 | tert-Butyl 2,2,2-trichloroacetimidate | tert-Butyl 2,2,2-trichloroacetimidate is a copper chelating ligand that acts as a transamidate in biochemical reactions and has antitumor and antimicrobial activities. |
| M40879 | [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid | [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a PEG-based degradable ADC linker and PROTAC linker that can be used in the synthesis of antibody active molecule couplers (ADCs) and PROTACs. |
| M40878 | Glutaric anhydride | Glutaric anhydride is a safe and non-toxic anhydride that can be used for research in drug delivery. |
| M40877 | Adipic anhydride | Adipic anhydride is an anhydride derivative whose polymer, polyadipic anhydride, can be used to synthesize microspheres that can be used for research in drug delivery. |
| M40876 | Ebdarokimab | Ebdarokimab is a monoclonal antibody to IL-12p40/IL-23 that can be used in studies related to inflammatory bowel disease (IBD). |
| M40875 | Brazikumab | Brazikumab is a human IgG2 monoclonal antibody targeting IL-23 that selectively binds to the p19 subunit of IL-23 and has a KD value of 0.138 nM against human IL-23 for Crohn's disease (CD). |
| M40874 | Recombinant Human PTH1R (Mammalian, C-6His) | Parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene, it belongs to the G-protein coupled receptor 2 family. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP). |
| M40873 | Recombinant Human TSHR Protein (Baculovirus-Insect, C-His) | Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. The recombinant human TSHR consists of 404 amino acids and predicts a molecular mass of 46.1 kDa. |
| M40872 | AFM32a hydrochloride | AFM32a hydrochloride is a benzimidazole-based derivative and a potent and selective protein arginine deiminase 2 (PAD2) inhibitor.AFM32a hydrochloride is more selective for PAD2 than PAD4 (95-fold) and PAD3 (79-fold). |
| M40871 | AFM32a | AFM32a is a benzimidazole-based derivative and a potent and selective protein arginine deiminase 2 (PAD2) inhibitor.AFM32a is more selective for PAD2 than PAD4 (95-fold) and PAD3 (79-fold). |
| M40868 | Licorice Polysaccharide | Licorice Polysaccharide is a natural plant active polysaccharide extracted from the traditional Chinese medicine Glycyrrhiza glabra with anticancer and immunomodulatory activities. |
| M40867 | DSPE-PEG-cRGD | DSPE-PEG-cRGDD is a polymeric material composed of components such as 1,2-didodecyl phosphatidyl lipid (DSPE), polyethylene glycol (PEG), and fibroblast adhesin receptor motif (cRGD). Among them, DSPE is a structurally stable phospholipid, PEG improves the water solubility and stability of polymeric materials, and cRGD is a peptide molecule that plays an important role in the adhesion pathway on the cell surface and has good cell recognition and binding ability. It can be used to prepare nanoparticles for targeting tumors. |
| M40866 | Meglutol | Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, serum beta-lipoproteins, and phospholipids, and inhibits the activity of the rate-limiting enzyme of cholesterol biosynthesis, HMG-CoA reductase. |
| M40865 | Peplomycin | Peplomycin is a peptide polyene compound derived from Streptomyces and a Bleomycin analog with high antitumor activity. In addition, Peplomycin induces a variety of skin abnormalities and induces apoptosis in oral squamous carcinoma SSCKN cells and lung fibrosis. |
| M40864 | Isepamicin | Isepamicin is an aminoglycoside antibiotic derived from actinomycetes with an antimicrobial spectrum that includes Enterobacteriaceae and Staphylococcus spp. and has been shown to have improved activity against strains producing type I 6'-acetyltransferase. |
| M40863 | Carumonam | Carumonam (AMA-1080) is a sulfonated monocyclic β-lactam antibiotic from Chromobacterium purpureum that targets penicillin-binding proteins (PBPs), is active against aerobic Gram-negative bacteria and is resistant to β-lactamase-mediated hydrolysis. |
| M40862 | Plaunotol | Plaunotol is an acyclic diterpenoid extracted from the stems and leaves of the Croton plant and can be used in studies related to gastric ulcers. |
| M40861 | Ganglioside GM1 | Ganglioside is a glycoside analog derived from animal brain tissue that promotes neural remodeling, such as neuronal cell survival, axonal growth and synaptogenesis. It also has a protective effect against secondary neurodegeneration after injury. |
| M40860 | Bucillamine | Bucillamine is an orally active endogenous cysteine derivative of the amino acid that also acts as a sulfhydryl donor with antiangiogenic, antioxidant, and anti-inflammatory activities, and is used in rheumatoid arthritis (RA), cystinuria, and gout studies. |
| M40859 | Schizophyllan | Schizophyllan, a β-D-glucan derived from Schizophyllan, activates Tc cells, NK cells, macrophages, as well as promotes the secretion of various lymphokines such as IL-1, IL-2, IL-3, IFN. It can be used as an immune adjuvant with potential immunomodulatory and antitumor activities. |
| M40858 | Miocamycin | Miocamycin is a macrolide antibiotic of Streptomyces origin that inhibits protein synthesis by binding to the bacterial 70S ribosome and is effective against a wide range of Gram-positive and Gram-negative microorganisms. |
| M40857 | Recombinant Human SIGLEC-7 Protein (HEK293, His Tag) | Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. |
| M40855 | Recombinant Human Siglec-7 Protein (Mammalian, C-6His) | Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. |
| M40853 | Recombinant Human SIGLEC-10 Protein (HEK293, mFc Tag) | The recombinant human SIGLEC-10 comprises 763 amino acids and has a calculated molecular mass of 84.60 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Thr546) was expressed with the Fc region of mouse IgG2a at the C-terminus. |
| M40852 | Recombinant Human SIGLEC-10 Protein (HEK293, His Tag) | The recombinant human SIGLEC-10 consists of 540 amino acids and predicts a molecular mass of 59.5 kDa. A DNA sequence encoding the human SIGLEC-10 (Met17-Asn550) was expressed with a polyhistidine tag at the C-terminus. |
| M40851 | SDC-1802 | SDC-1802 is a JAK1/TYK2 inhibitor that can be used in studies related to systemic lupus erythematosus. |
| M40850 | OST-246 | OST-246 is an inhibitor of JAK3, MAP3K11, and TYK2 for studies related to autoimmune diseases and inflammation. |
| M40849 | NDI-031232 | NDI-031232 is a TYK2 inhibitor. |
| M40848 | NDI-031301 | NDI-031301 is a TYK2 inhibitor. |
| M40847 | NDI-031407 | NDI-031407 is a TYK2 inhibitor for studies related to endocrine metabolic diseases and psoriasis. |
| M40846 | A2A-I-01 | A2A-I-01 is a TYK2 inhibitor that can be used in studies related to autoimmune diseases. |
| M40845 | Recombinant Human Siglec-6 Protein (Mammalian, C-Fc) | Siglec-6, also known as CD327, mediates sialic-acid dependent binding to cells. Siglec-6 binds to alpha-2,6-linked sialic acid. |
| M40844 | Recombinant Human Siglec-10 Protein (Mammalian, C-Fc) | Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. |
| M40843 | Recombinant Human Siglec-9 Protein (Mammalian, C-Fc) | Sialic acid-binding Ig-like lectin 9(Siglec 9) is expressed by peripheral blood leukocytes, and found in liver, fetal liver, bone marrow, placenta, spleen and so on. It is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It also binds to alpha-2,3- or alpha-2,6-linked sialic acid. |
| M40842 | Recombinant Human Siglec-15 Protein (Mammalian, C-mFc) | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
| M40841 | Recombinant Human Siglec-15 Protein (Mammalian, C-Fc) | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglec-15 is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
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