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| Cat.No. | Name | Information |
|---|---|---|
| M21330 | H3K4(Me3) (1-20) | H3K4(Me3) (1-20), a histone polypeptide, trimethylation of histone H3 to lysine 4 (H3K4 me3) is found in active euchromatin. Sequence: Ala-Arg-Thr-{Lys(Me3)}-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu. |
| M21329 | Histone H2A (1-20) | Histone H2A (1-20) is a 35 amino acid histone H2A peptide fragment that is a substrate for methyltransferase/demethylase enzymes. Sequence: Ser-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Ala-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-Arg. |
| M21328 | Antennapedia Peptide | Antennapedia Peptide is a peptide consisting of 16 amino acid residues derived from the homologous domain of the 60 amino acid sequence of the Drosophila transcription factor Antennapedia, which is also a membrane piercing peptide.Sequence：Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys. |
| M21327 | Human PD-L1 inhibitor V | Human PD-L1 inhibitor V is a human PD-1 protein binding peptide with a Kd value of 3.32 μM that inhibits the binding of human PD-1/PD-L1.Sequence:Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln. |
| M21326 | Recombinant Schistosoma Japonicum GST（E.coli） | Recombinant Schistosoma japonicum glutathione S-transferase Class-mu 26 kDa Isozyme was produced by E. coli expression system and the target gene encoding Met1-Lys218 was expressed. Protein no：P08515. |
| M21325 | β-Casomorphin, human | β-Casomorphin, human is an opioid-like peptide that is an opioid receptor agonist. Sequence: Tyr-Pro-Phe-Val-Glu-Pro-Ile. |
| M21324 | β-Casomorphin, bovine | β-casomorphin, bovine (β-Casomorphin-7 (bovine)) is an opioid-active peptide with an IC50 value of 14 μM for binding to opioid receptors.Sequence：Tyr-Pro-Phe-Pro-Gly-Pro-Ile. |
| M21323 | ACT-660602 | ACT-660602 is an oral chemokine receptor CXCR3 antagonist with an IC50 of 204 nM. It is being developed for use in autoimmune diseases. |
| M21322 | GNE-064 | GNE-064 is an orally administered brominated structural inhibitor of SMARCA2/4 and PBRM1 and is being developed as a tool compound.GNE-064 inhibits SMARCA4 with an IC50 value of 0.035 μM and also SMARCA2 with an EC50 value of 0.10 μM. |
| M21321 | SPH3127 | SPH3127 is an oral direct renin inhibitor (DRI) that is being developed for hypertension. The renin-angiotensin-aldosterone system is responsible for the regulation of blood pressure. |
| M21320 | SAFit2 | SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51) with a Ki value of 6 nM. SAfit2 has been used as a potential agent in the study of major depression, obesity, and chronic pain. |
| M21319 | CG428 | CG428 (TRK kinase fusion protein degrader). |
| M21318 | Biotin-PEG4-amino-t-Bu-DADPS-C6-azide | Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PROTAC linker, which belongs to the PEG class. It can be used for the synthesis of PROTAC molecules.*The compound is unstable in solutions, freshly prepared is recommended |
| M21317 | EST73502 | EST73502 is a selective, orally active, μ-opioid receptor (μ-opioid receptor/MOR) agonist and σ1 receptor (σ1R) antagonist that crosses the blood-brain barrier with Ki values of 64 nM and 118 nM for MOR and σ1R effects, respectively. EST73502 can be used in pain relief studies. |
| M21316 | BAY-6672 | BAY-6672 is a potent and selective human prostaglandin F (FP) receptor antagonist with an IC50 value of 11 nM. |
| M21315 | lipid 10a | “lipid 10a” (Arcturus tunable lipid for RNA drug delivery). |
| M21314 | LEO 39652 | LEO 39652 is a dual-soft PDE4 inhibitor with IC50 values of 1.2 nM for PDE4A, 1.2 nM for PDE4B, 3.0 nM for PDE4C, and 3.8 nM for PDE4D. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used in topical studies of atopic dermatitis. |
| M21313 | Pulrodemstat | Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine-specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. |
| M21312 | BAY 1217224 | BAY 1217224 is a neutral non-premedication inhibitor of Thrombin with good oral pharmacokinetics. |
| M21311 | BAY 1214784 | BAY 1214784 is a potent, selective and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R).BAY 1214784 has the potential to be studied in uterine fibroids. |
| M21310 | ACT-1004-1239 | ACT-1004-1239 is a potent, selective, orally administered CXCR7 antagonist with an IC50 value of 3.2 nM. |
| M21309 | 3-MORPHOLINOSYDNONIMINE | |
| M21308 | Liperfluo | |
| M21307 | Romiplostim | |
| M21306 | UNC6852 | UNC6852 is a PROTAC technology-based, selective PRC2 degradation agent containing an EED ligand and a von Hippel-Lindau ligand with an IC50 value of 247 nM for EED action. |
| M21305 | 2,2'-Bipyridine | 2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
| M21304 | Thiobarbituric acid | Thiobarbituric acid has antibacterial activity. |
| M21303 | Trientine-2HCl | Trientine-2HCl is a chelating agent used in the study of Wilson's disease by binding and scavenging copper from the body.Trientine-2HCl is also used as a chelating agent for copper in hepatocyte degeneration, as a stabilizer for epoxy resins, and as an ampholyte for isoelectric focusing. |
| M21302 | Narasin | Narasin is a cationic ion carrier and anticoccidial agent. narasin inhibits NF-κB signaling and induces apoptosis (tumor cell death), it has activity against gram-positive bacteria, anaerobic bacteria, mycoplasma and coccidia, and it also has antiviral effects. |
| M21301 | Pelacarsen | Pelacarsen (AKCEA-APO(a)-LRx) is a liver-specific, antisense oligonucleotide targeting apolipoprotein(a) that reduces lipoprotein(a) by 80% and is well tolerated. |
| M21300 | Luvadaxistat | Luvadaxistat (TAK-831) is a potential first-in-class D amino acid oxidase (DAAO) inhibitor that could be used in schizophrenia research. |
| M21299 | D-Glucosemonohydrate | D-(+)-glucose monohydrate is a common natural sugar involved in processes such as glycosylation, energy production, and the formation of glycans, which are structural components of cells. d-(+)-glucose monohydrate can also cause glycation, which is a harmful process in cells. It is used as a supplement for many cellular processes and cell culture. |
| M21298 | BMS-986202 | BMS-986202 is a potent, selective, orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 of 14 μM. BMS-986202 can be used in IL-23-driven echinococcosis BMS-986202 can be used in studies of IL-23-driven echinococcosis, anti-CD40-induced colitis and spontaneous lupus. |
| M21297 | TP0586352 | TP0586352 is an LpxC inhibitor effective against carbapenem-resistant Klebsiella pneumoniae with no cardiovascular risk. |
| M21296 | PF-06843195 | PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts.The Ki of PF-06843195 acting on PI3Kα and PI3Kδ is less than 0.018 nM and 0.28 nM, respectively.PF-06843195 has a significant inhibitory effect on PI3K/mTOR signaling pathway and had a long-lasting anti-tumor effect. |
| M21295 | PF07059013 | PF07059013 is a non-covalent oral hemoglobin (HbS) modulator. |
| M21294 | OI338 | OI338 is an oral, long-acting insulin analogue. |
| M21293 | BCPyr | BCPyr is a new candidate BTK degradation agent (DC50 = 800 nM). |
| M21292 | EB-42486 | EB-42486 is a novel potent and highly selective inhibitor of G2019S-LRRK2 (IC50 < 0.2 nM). |
| M21291 | MLT-985 | MLT-985 is a highly selective inhibitor of MALT1 conformation with an IC50 value of 3 nM. |
| M21290 | BMS-986144 | BMS-986144 is a third generation pan-genotypic NS3/4A protease inhibitor.BMS-986144 inhibits GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, 1b D168V replicon with EC50 values of 2.3, 0.7, 1.0, 12, 8.0, 5.8 nM, respectively.BMS-986144 has the potential to study HCV infection. |
| M21289 | Peptide 78 | Peptide 78, a chemotactic cytokine, consists of 78 amino acids and is a member of the IL-8 or C-X-C chemokine supergene family of proteins. peptide 78 induces neutrophils (PMN) that play an important role in rheumatoid arthritis (RA) joints. Sequence: TMRKPRSGNPDVAN. |
| M21288 | LY3502970 | LY3502970 (GLP-1 receptor agonist 1) is a glucagon-like peptide (GLP-1) receptor agonist. |
| M21287 | PF-06835919 | PF-06835919 is an oral Class I clinical candidate for NAFLD/NASH, targeting ketohexokinase (KHK), an enzyme that initiates fructose metabolism. |
| M21286 | PF-05221304 | PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first step of adipogenesis ab initio (DNL). |
| M21285 | AL-611 | AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM). |
| M21284 | BMS-986143 | BMS-986143 is a potent, reversible inhibitor of tyrosine kinase (BTK), which has been successfully targeted by a number of irreversible tumor compounds. |
| M21283 | ASP5286 | ASP5286 is a novel non-immune cyclophilin inhibitor for the study of HCV. |
| M21282 | BI-0115 | BI-0115 inhibits the C-type lectin family member lectin-like oxidized LDL-receptor-1 (LOX-1) by stabilizing an inactive tetrameric form of the protein. |
| M21281 | BAY 1003803 | BAY 1003803 is a glucocorticoid receptor agonist for the study of topical psoriasis or severe atopic dermatitis. |
| M21280 | JNJ-53718678 | JNJ-53718678 is a potent and orally available fusion inhibitor of the RSV virus, optimized from a prior oral inhibitor, BMS-433771. |
| M21279 | MK-5204 | MK-5204 is a broad spectrum Candida antifungal agent derived from the natural product, enfumafungin. |
| M21278 | Recombinant Mouse IL-12 (CHO) | Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine consisting of p35 and p40 subunits. ed50 < 0.15 ng/ml, measured in a cell proliferation assay using 2D6 cells. |
| M21277 | GSK232 | GSK232 is a highly selective inhibitor of cell permeation of non-BET CECR2 brominated structures with >500-fold selectivity for BET family brominated structures. |
| M21276 | NLG802 | NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor. |
| M21275 | ONO-8430506 | ONO-8430506 is a potent autotaxin phosphodiesterase inhibitor with significant oral exposure and low clearance in higher species. |
| M21274 | RO7185876 | RO7185876 is a gamma-secretase modulator (GSM) for the study of Alzheimer's disease. |
| M21273 | GNE-149 | GNE-149 is an efficient monovalent degrader and full antagonist of estrogen receptor alpha with significant oral bioavailability in higher species. |
| M21272 | BMS-986235 | BMS-986235/LAR-1219 is an FPR1-sparing FPR2-selective agonist designed to help address chronic inflammation/promote wound healing to prevent serious complications such as heart failure. |
| M21271 | DS-1971a | DS-1971a is a potent, homozygous form-selective aryl sulfonamide NaV1.7 inhibitor for the treatment of neuropathic pain. |
| M21270 | JNJ-54717793 | JNJ-54717793 is a selective octreotide-1 receptor antagonist used in studies of anxiety disorders, unlike the dual octreotide-1/2 inhibitors and octreotide-2 inhibitors typically used in sleep disorders. |
| M21269 | EC2629 | EC2629 is a folate receptor (FR)-targeting small molecule drug conjugate with a folate receptor-targeting molecule, a pyrrole-ring benzodiazepine (PBD) DNA cross-linked warhead and a linker. |
| M21268 | ETX0282 | ETX0282 is an oral prodrug of a class A, C and D serine beta-lactamase inhibitor in clinical development in combination with the beta-lactam drug cefpodoxime proxetil. |
| M21267 | LXE408 | LXE408 is an oral antileishmanarial compound that selectively targets the kinetoplastid proteosome vs. the mammalian proteosome. |
| M21266 | MGS0274 | MGS0274 is a lipid-soluble precursor drug for the mGlu2 and mGlu3 receptor agonist MGS0008, which improves oral bioavailability. mGS0274 has potential for use in the study of schizophrenia. |
| M21265 | Eicosapentaenoic Acid | Eicosapentaenoic acid (EPA) is an omega-3 fatty acid found in fish oil. It acts as a precursor to prostaglandin-3 and thromboxane-3 families. EPA decreases serum lipid concentration, reduces the risk of cardiovascular disorders and suppresses platelet aggregation.Nutritional supplement in health care products. |
| M21264 | HTL22562 | HTL22562 is a CGRP antagonist intended for use in studies of acute migraine. |
| M21263 | X-165 | X-165 is a clinical candidate compound for the study of autologous cell inhibitors in idiopathic pulmonary fibrosis, which was discovered through a 3-cycle DEL screen of 225M compounds obtained from amide coupling. |
| M21262 | FT3967385 | FT3967385 is a novel USP30 inhibitor that recapitulates the genetic deletion of USP30 and triggers mitochondrial ubiquitination of PINK1-PARKIN amplification. |
| M21261 | Xeruborbactam | Xeruborbactam (QPX7728) is a potent, ultra-broad-spectrum inhibitor of boronic acid beta-lactamase. xeruborbactam inhibits serine and metallo-beta-lactamases in the nanomolar range. |
| M21260 | CPI-1612 | CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species. |
| M21259 | GSK2818713 | GSK2818713 is an HCV NS5A replication complex inhibitor with an interesting biphenyl ligand. |
| M21258 | S6821 | S6821 is one of the two potent and selective TAS2R8 GPCR antagonists disclosed. |
| M21257 | MK-6884 | MK-6884 is an M4 muscarinic receptor orthomodulator (PAM) with a Ki value of 0.19 nM. MK-6884 is used in the study of neurodegenerative diseases. MK-6884 can be used as a positron emission computed tomography imaging agent with 11C radiolabeling. |
| M21256 | CD73-IN-2 | CD73-IN-2 is a potent CD73 inhibitor with an IC50 of 0.09 nM. |
| M21233 | IDO1/TDO-IN-4 | IDO1/TDO-IN-4 is a potent dual IDO1/TDO inhibitor with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bonds with IDO1 and interacts with TDO in π-π stacking. IDO1/TDO-IN-4 can be used in the study of depression, as well as depression-induced infectious, metabolic and autoimmune diseases. |
| M21232 | MeBIO | MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist. |
| M21231 | PROTAC CDK9 Degrader-1 | PROTAC CDK9 Degrader-1 is a PROTAC linked by Cereblon ligand and CDK ligand and is a selective CDK9 degrader. |
| M21230 | GNF2133 | GNF2133 is a potent, selective, orally active DYRK1A inhibitor with IC50s of 0.0062 and >50 µM for DYRK1A and GSK3β, respectively. GNF2133 has potential for the study of type 1 diabetes. |
| M21229 | BMS-986260 | BMS-986260 is a potent, selective, orally available TGFβR1 inhibitor with an IC50 of 1.6 nM. |
| M21228 | WF-47-JS03 | WF-47-JS03 is a potent and selective RET kinase inhibitor with more than 500-fold selectivity for the kinase insertion domain receptor (KDR).WF-47-JS03 acts on Ba/F3 cells transfected with KIF5B-RET and LC-2/ad lung cancer cells transfected with CCDC6-RET with IC50s of 1.7 nM and 5.3 nM, respectively. crossed the blood-brain barrier. |
| M21227 | HR011303 | Gout is caused by a buildup of uric acid. The main treatments are drugs that increase the production of uric acid (uric acid analogues, such as propoxur) and xanthine oxidase inhibitors that inhibit uric acid. |
| M21226 | SEP-363856 | SEP-363856 (SEP-856) is an orally active, CNS-active antipsychotic active compound with potential for the study of schizophrenia. |
| M21225 | HTT-D3 | HTT-D3 is a potent and orally active regulator of Huntington (HTT) splicing. HTT-D3 acts by promoting pseudo-exons containing the premature termination codon (psiExon), resulting in HTT mRNA degradation and reduced HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux and can be used in Huntington's disease research. |
| M21224 | CC-90001 | CC-90001 is a JNK (c-Jun N-terminal kinase) inhibitor that can be used as a Phase II clinical candidate to study idiopathic pulmonary fibrosis. |
| M21223 | DS96432529 | DS96432529 is a potent bone anabolic agent with oral activity and CDK8 inhibitory activity. |
| M21222 | BIIB091 | The reversible BTK kinase inhibitor BIIB091 is a highly selective phase I clinical candidate compound for multiple sclerosis. |
| M21221 | SY-5609 | The CDK7 kinase inhibitor SY-5609 is a picomolar, reversible, highly selective molecule with slow off-rate kinetics. SY-5609 has a weak inhibitory effect on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), and CDK12 (Ki=870 nM). |
| M21220 | ASP2453 | ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits Son of Sevenless (SOS)-mediated interactions between KRAS G12C and Raf with an IC50 value of 40 nM. |
| M21219 | Maralixibat chloride | Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. (IBAT) is used in the study of rare cholestatic liver diseases, including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC), and biliary atresia. |
| M21218 | Sapienic acid sodium | Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively. |
| M21217 | (-)-JNJ-A07 | (-)-JNJ-A07 is a potent and selective inhibitor of dengue virus (DENV) with an EC50 of 31 nM. |
| M21216 | (+)-JNJ-A07 | (+)-JNJ-A07 is a potent pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against 21 clinical isolates. (+)-JNJ-A07 has a good pharmacokinetic profile and showed significant efficacy against dengue virus infection in a mouse infection model. |
| M21215 | CP-628006 | The CFTR potentiator CP-628006 enhances CFTR function in cystic fibrosis patient-derived air chamber cells by a mechanism of action different from that of existing potentiators such as ivacaftor. |
| M21214 | AS-0141 | AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with antitumor activity as described in WO2019165473A1, compound I-D. Cdc7 is a serine threonine protein kinase enzyme that is essential for the initiation of DNA replication during the cell cycle. |
| M21213 | Tibolone | Tibolone is a synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities. |
| M21212 | Recombinant Human Arylsulfatase A/ARSA (Mammalian, C-6His) | Recombinant Human Arylsulfatase A/ARSA is produced by a mammalian expression system and encodes the Arg19-Ala507 target gene with a 6His tag at the C-terminus. Protein ID: P15289. |
| M21211 | Lalistat 1 | Lalistat 1 is a lysosomal acid lipase inhibitor with IC50 value of 68 nM. It can block LAL-mediated lipid hydrolysis of acetylated LDL and reduce efflux of cholesterol from lipid-loaded cells. |
| M21210 | Recombinant Mouse IL-3 (E. coli) | ED50 < 0.05 ng/ml, measured by cell proliferation assay using M-NFS-60 cells, corresponds to specific activity > 2.0 × 10 7 units/mg. Accession # P01586. |
| M21209 | Heparin Lithium salt | Heparin Lithium salt is an anticoagulant that binds reversibly to antithrombin III (ATIII). |
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