| Cat.No. | Name | Information |
|---|---|---|
| M58510 | Recombinant Mouse GAPDH Protein (E. coli, N-His) | GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58507 | Recombinant Human Galectin-3 Protein (HEK293, C-His) | Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain. LGALS3 (Galectin 3) has an important role in tumor progression through inhibition of apoptosis. |
| M58506 | Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. |
| M58504 | Cyclocreatine | Cyclocreatine acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. |
| M58502 | 4-Hydroxyestrone | 4-Hydroxyestrone (4-OHE1) is an estrone metabolite, it has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. |
| M58501 | Phentolamine | Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. |
| M58500 | EverFluor Fl C5-Ceramide | BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em= 505 nm/512 nm |
| M58499 | BODIPY TR Ceramide | BODIPY TR Ceramide (Golgi-Red Tracke) is a Golgi-specific fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em=589 nm/616 nm |
| M58498 | SR-4995 | SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling. |
| M58492 | CS-6253 | CS-6253 is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles. |
| M58491 | Trypsin (bovine pancreas) | Trypsin is a serine protease in the digestive system of human and animals. The main function of this enzyme is to hydrolyze proteins into smaller peptides or even amino acids. |
| M58490 | Sulfo-Cy5.5 maleimide | Sulfo-Cy5.5 maleimide |
| M58489 | Cyanine5.5 maleimide | Cyanine5.5 maleimide |
| M58488 | Z-VAD | Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. |
| M58487 | NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively. |
| M58486 | XST-14 | XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 has antitumor effects. |
| M58485 | Vacuolin-1 | Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. |
| M58484 | Torcitabine | Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection research. Torcitabine (2'-Deoxy-L-cytidine) shows greater inhibition of first strand than second strand DNA synthesis. |
| M58483 | N-Acetyl-L-cysteine ethyl ester | N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. |
| M58480 | Nenocorilant | Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. |
| M58478 | BODIPY TR methyl ester | BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo. BODIPY TR methyl ester is a lipophilic GFP counterstain, it readily permeates cell membranes and localizes in endomembranous organelles. |
| M58476 | SGK1-IN-4 | SGK1-IN-4 is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 can be used for the research of osteoarthritis. |
| M58475 | DDR2-IN-1 | DDR2-IN-1 is potent DDR2 inhibitor with an IC50 of 26 nM. DDR2-IN-1 can be used for osteoarthritis research. |
| M58474 | C14 Ceramide | C14 Ceramide is an ester product. |
| M58473 | SLC3037 | SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. |
| M58470 | WL47 TFA | WL47 TFA, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 TFA shows selectivity for CAV1 over BSA, casein and HEWL. WL47 TFA can be used for the study of caveolin-1 function. |
| M58469 | CS-6253 TFA | CS-6253 TFA is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 TFA improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 TFA generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles. |
| M58468 | Thyroid hormone receptor antagonist (1-850) | Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. |
| M58467 | Chitosan (≥95% deacetylated, MW 50000-60000) | Chitosan (≥95% deacetylated, MW 50000-60000) is a polycationic linear polysaccharide derived from chitin .Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
| M58464 | IR-780 | IR-780 is a near‐infrared fluorescent dye, is used for the exclusive characterization of human CSCs through the HIF‐1α/glycolysis dependent mitochondrial transporter ABCB10's activity. The maximum excitation wavelength of IR-780 was 777-780 nm, and the maximum emission wavelength was 798-823 nm. IR-780 can be used in cancer PTT/PDT and imaging. |
| M58463 | WDR5-IN-4 | WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity. |
| M58462 | SSK1 | SSK1 is a senescence-specific killing compound and is a precursor for β-galactosidase, which can reduce the inflammatory response. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, promote mitochondrial DNA damage and selectively killed senescent cells. |
| M58461 | p38 MAP Kinase Inhibitor III | p38 MAP Kinase Inhibitor III is a p38 MAPK inhibitor with an IC50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with IC50 values of 0.37 μM and 0.044 μM, respectively. |
| M58460 | NAD sodium | NAD sodium (β-Nicotinamide adenine dinucleotide sodium salt) is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP. |
| M58458 | MR-L2 | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM. |
| M58456 | Allo-aca | Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models. |
| M58455 | VRK-IN-1 | VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders. |
| M58454 | CO23 | CO23 is a selective thyroid hormone receptor (TR) α agonist, it is used for growth and development regulation. CO23 can be transported through the blood-brain barrier. |
| M58453 | Recombinant Human BMP-6 (E.coli, C-His) | Bone Morphogenetic Protein-6 (BMP-6) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-6 can bind with the TGF-β receptor and triggers SMAD protein signal transduction. It plays a vital role in regulating hepcidin to maintain iron ions in the body. |
| M58452 | DSPE-Se-Se-PEG2000 | DSPE-Se-Se-PEG2000 is a functional polyethylene glycol (DSPE-PEG) liposome derivative with disulfide bond linkage that plays an important role in gene delivery. This liposome is able to encapsulate DNA or RNA genes and protect them from various intracellular degradations and damages, as well as improve the efficiency and stability of gene transfection. |
| M58451 | Sevabertinib | Sevabertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with antitumor activity. |
| M58450 | Angiopep-2-Cys TFA | Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride and cysteine. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer. |
| M58449 | Orange G | Orange G is a dye used primarily as a histological stain. It can be used as a biological material or organic compound for life science related research. |
| M58447 | 1alpha-Hydroxy VD4 | 1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells. |
| M58446 | HKOCl-4 | HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity. HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm. |
| M58445 | Hydroxyphenyl Fluorescein | Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm. |
| M58441 | Sabirnetug | Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein. |
| M58440 | Soquelitinib | Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease. Soquelitinib increases tumor infiltration of normal CD8+ cells that possess enhanced T effector function. |
| M58439 | Ozekibart | Ozekibart is an anti-TNFRSF10B monoclonal antibody. |
| M58438 | Tividenofusp alfa | Tividenofusp alfa (DNL-310) is a fusion protein composed of IDS fused to Denali's proprietary Enzyme Transport Vehicle (ETV). |
| M58437 | LB-102 | LB-102 is an orally active inhibitor of dopamine D2, D3, and 5-HT7 receptors. |
| M58435 | Pifithrin-α, p-Nitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue. |
| M58428 | EpoY | EpoY is an irreversible inhibitor of the major brain tubulin tyrosine carboxypeptidase (TCP), shown to be a complex of vasohibin-1 (VASH1) with the small vasohibin binding protein (SVBP). |
| M58427 | Tetrahydrouridine | Tetrahydrouridine (THU) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
| M58425 | Acridine Orange | Acridine Orange is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. |
| M58421 | DC-Y13-27 | DC-Y13-27, a derivative of DC-Y13, is a YTHDF2 inhibitor (KD = 37.9 μM). DC-Y13-27 enhances tumor responses to radiotherapy and immunotherapy. |
| M58419 | L-Leucyl-L-Leucine methyl ester hydrochloride | L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress. |
| M58418 | Crisnatol | Crisnatol (BWA770U) is a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells. Crisnatol (BWA770U) is also an orally active and anticancer agent. |
| M58417 | C6 Ceramide | C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. |
| M58416 | CCB02 | CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. |
| M58415 | Cu(II)-Elesclomol | Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. |
| M58414 | GAK inhibitor 49 | GAK inhibitor 49 is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. |
| M58413 | MMP2-IN-1 | MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. |
| M58411 | PV-1019 | PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits IR-induced apoptosis. |
| M58410 | Risvodetinib | Risvodetinib (IkT-148009) is an orally active, selective and brain-penetrant protein tyrosine kinase inhibitor, displaying excellent target efficacy against c-Abl1, c-Abl2/Arg with IC50 values of 33 nM, 14 nM, respectively. |
| M58409 | CM-444 | CM-444 is an inhibitor for HDAC and DNA methyltransferases (DNMT) with IC50 values of 6 nM-0.6 μM and 1.8-2.3 μM, respectively. CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models. |
| M58408 | CM-1758 | CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 inhibits tumor growth in vivo. CM-1758 induces acetylation of non-histone proteins in acute myeloid leukemia cells. |
| M58405 | Nanaomycin A | Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. |
| M58404 | Rosoxacin | Rosoxacin (Acrosoxacin) is an orally active and broad-spectrum antibacterial quinolone antibiotic. Rosoxacin inhibits Gram-negative bacteria, including N. gonorrhoeae (MIC range=0.03-0.125 µg/mL). |
| M58403 | 2-Nitrosopyridine | 2-Nitrosopyridine is a nitroso compound that can be used to synthesize antibiotics. 2-Nitrosopyridine can be used as a Click or Diels-Alder derivatization reagent and an excellent dienophile. |
| M58402 | Cethromycin | Cethromycin (ABT-773) is a ketolide antibiotic. |
| M58401 | ASK1-IN-1 | ASK1-IN-1 is a novel CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). |
| M58400 | CZC-54252 hydrochloride | CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. |
| M58399 | F-1 | F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50 values of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. |
| M58398 | Corticotropin Releasing Factor | CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress. |
| M58397 | Sulfo-LC-SPDP sodium | Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| M58396 | Recombinant Human METRNL Protein (E. coli, N-His) | METRNL (Meteorin-like protein) is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions. |
| M58395 | 8-Hydroxyguanosine | 8-Hydroxyguanosine is a marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. 8-Hydroxyguanosine is a purine nucleoside, it stimulates proliferation and differentiation of B cells. |
| M58394 | TRITC | TRITC (5(6)-Tetramethylrhodamine isothiocyanate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| M58393 | Isoxanthopterin | Isoxanthopterin is a heterocyclic compound belonging to the pteridine family. |
| M58392 | cis-Urocanic acid | cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is also an immune modulator that induces immunosuppression. |
| M58391 | trans-Urocanic acid | trans-Urocanic acid is a natural epidermal constituent, which inhibits human natural killer cell (NK) activity in vitro. trans-Urocanic acid is active in regulating an immune function. |
| M58390 | EGTA-AM | EGTA-AM is a membrane permeable form of EGTA, which can be passively loaded into cells to generate intracellular EGTA. EGTA-AM is also a Ca2+ chelator with slow chelating dynamics. |
| M58389 | (E/Z)-Zotiraciclib citrate | (E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor. |
| M58388 | Abemaciclib metabolites M2 | Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50 values of 1.2 and 1.3 nM, respectively. |
| M58387 | CDK9-IN-1 | CDK9-IN-1 is a novel, selective CDK9 inhibitor, with an IC50 of 39 nM for CDK9/CycT1, it can be used for the research of HIV infection. |
| M58386 | Moringin | Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. |
| M58385 | Vanillylamine | Vanillylamine is a derivative of vanillin is synthesized through a transaminase reaction in the phenylpropanoid pathway of capsaicinoid synthesis. |
| M58384 | Neuraminidase | Neuraminidase is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. |
| M58383 | Recombinant Human HK2 Protein (E. coli, N-His) | Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
| M58382 | Recombinant Human HK2 Protein (Baculovirus-Insect, C-His) | Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
| M58381 | Manganese(salen) chloride | Manganese(salen) chloride (EUK-8) is a superoxide dismutase and catalase mimetic, it is an antioxidant with oxyradical scavenging properties. |
| M58380 | Ivermectin B1a | Ivermectin B1a is a main component of Ivermectin. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. |
| M58379 | Pelitrexol | Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. |
| M58378 | Taurodeoxycholic acid | Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. |
| M58377 | Anserine | Anserine is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. |
| M58376 | Nacubactam | Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. |
| M58375 | Recombinant Human HER2 Protein (HEK293, C-6His) | Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. |
| M58374 | Lexithromycin | Lexithromycin is an erythromycin A derivative, with antibacterial activity. |
| M58373 | Virginiamycin M1 | Virginiamycin M1 (Pristinamycin IIA) is an polyunsaturated macrocyclic lactone antibiotic produced by Streptomyces virginiae, Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL. |
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