| Cat.No. | Name | Information |
|---|---|---|
| M58633 | PCL-PEG-MAL | PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation. |
| M58630 | JPE-1375 | JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice. |
| M58628 | Recombinant Mouse Progranulin Protein (HEK293, C-His) | Progranulin (PGRN) proteins regulate lysosomal function, affecting protein transport, enzymatic activity, and acidification. It degrades mature cathepsin D via cathepsin B. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. |
| M58627 | Recombinant Human FGF-8b Protein (E. coli) | Recombinant Human FGF-8b Protein is a heparin-binding growth factor, which plays a core role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and other effect. |
| M58620 | Amylin amide, human TFA | Amylin amide, human TFA is a 37-amino acid polypeptide, it is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin amide, human TFA inhibits glucagon secretion, delays gastric emptying. |
| M58618 | Recombinant Rat GDNF Protein (Baculovirus-Insect, N-His) | GDNF is an important member of the GDNF family of ligands. GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. |
| M58611 | Recombinant Human SOD1 Protein (E. coli, N-6His) | SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. |
| M58610 | Recombinant Human SOD2 (HEK293, C-6His) | SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. |
| M58609 | Dencatistat | Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM. |
| M58608 | DSPE-PEG-Streptavidin | DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity. |
| M58607 | OPC-163493 | OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. |
| M58606 | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp). (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical Wnt/β‐catenin signaling pathway. |
| M58604 | Vipoglanstat | Vipoglanstat (BI 1029539) is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = ≤0.5 nM in isolated human whole blood). Vipoglanstat reduces LPS-induced increases in the influx of neutrophils and levels of cytokines in bronchoalveolar lavage fluid (BALF), as well as the expression of PTGES, the gene encoding mPGES-1, Cox2, and Icam1 in the lung parenchyma, in a human PTGES knock-in mouse model of acute lung injury when administered at a dose of 30 mg/kg. |
| M58602 | Recombinant Rat PDGF-BB (E. coli) | Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. |
| M58600 | Recombinant Human ApoE3 Protein (HEK293, C-6His) | ApoE is a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. |
| M58599 | Antipain dihydrochloride | Antipain dihydrochloride is a protease inhibitor. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride also restricts uterine DNA synthesis and function in mice. |
| M58590 | Recombinant Mouse Granzyme B (HEK293, C-6His) | Granzyme B (GZMB) is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| M58589 | Sulfatase (from Helix pomatia) | Sulfatase (from Helix pomatia) facilitates the synthesis of thiohydroximates. It causes the hydrolysis of β-naphthyl sulfate much faster than a-naphthyl sulfate and possesses regiospecificity in the hydrolysis of ortho and para substituted phenyl sulfates. |
| M58588 | E7107 | E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor. |
| M58587 | F7H | F7H is a Frizzled receptor FZD7 antagonist with IC50 of 1.25 μM. F7H is a potent ligand for the FZD7 transmembrane domain (TMD). |
| M58586 | UU-T02 | UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction, with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling. |
| M58585 | Wnt/β-catenin agonist 1 | Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. |
| M58584 | (E)-Akt inhibitor-IV | (E)-Akt inhibitor-IV is a PI3K-Akt inhibitor, with potent cytotoxic. |
| M58583 | Ulacamten | Ulacamten is a potent cardiac myosin inhibitor. |
| M58581 | MS4322 | MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. |
| M58580 | Tegaserod | Tegaserod is an orally active serotonin receptor 4 (5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. |
| M58578 | DASPEI | DASPEI is a cationic styrenyl mitochondrial dye. DASPEI has excitation and emission wavelength at 550/573 nm, which has good light chromogenic property. DASPEI can stain mitochondria in living cells with good labeling property. DASPEI can also be used to stain presynaptic nerve endings independently of neuronal activity. |
| M58577 | Zinquin ethyl ester | Zinquin ethyl ester is a fluorescent probe of cytosolic zinc ion. Zinquin ethyl ester is able to penetrate cell membranes and is lipophilic and zinc-sensitive. Zinquin ethyl ester can combine with Zn2+ in the cell to produce blue fluorescence. |
| M58576 | HKOH-1r | HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively. |
| M58575 | ATP-Red 1 | ATP-Red 1 is a multisite-binding switchable fluorescent probe, and it can selectively and rapidly responds to intracellular concentrations of ATP in living cells. Live-cell imaging indicated that ATP-Red 1 mainly localized to mitochondria with good biocompatibility and membrane penetration. ATP-Red 1 is a useful tool for investigating ATP-relevant biological processes. |
| M58574 | (±)-ANAP hydrochloride | (±)-ANAP hydrochloride is the amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity with comparable or increased brightness. (±)-ANAP hydrochloride is sensitive to polarity with changes in intensity and emission wavelength. |
| M58573 | DYRK1-IN-1 | DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC50 value of 220 nM. |
| M58572 | Coumberone | Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. |
| M58571 | Sulforhodamine B | Sulforhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Sulforhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays. |
| M58570 | AF488 NHS ester TEA | AF488 NHS ester TEA is an amine specific fluorescence probe. AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively. |
| M58569 | KL044 | KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity. |
| M58568 | EtS-DMAB | EtS-DMAB (HClO-green) is a fluorescent probe, which can selectively detect hypochlorous acid (HOCl) (λex=440 nm, λem=610 nm). EtS-DMAB is applied to image exogenous and endogenous HOCl in live cells. |
| M58567 | HKPerox-1 | HKPerox-1 is a highly sensitive green fluorescent probe for the specific detection of H2O2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively. |
| M58566 | HKOH-1 | HKOH-1 is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively. |
| M58565 | HKPerox-2 | HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H2O2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively. |
| M58564 | 3,3'-Dipropylthiadicarbocyanine iodide | DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. |
| M58563 | Sulfo-NHS-SS-Biotin sodium | Sulfo-NHS-SS-biotin is a long-chain cleavable and cell-impermeant amine-reactive biotinylation reagent. Sulfo-NHS-SS-biotin can be used for the labeling and purifying of cell-surface protein. |
| M58562 | Prostaglandin D2 | Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals. PGD2 plays a protective role by suppressing inflammation. |
| M58561 | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research. |
| M58560 | Glucocerebrosides (Soy) | Glucosylceramide (GluCer) is a major sphingolipid of plant tissue and, thus, abundant in nature and in dietary food sources. Soybean GluCer was comprised primarily (>98%) of ceramide with 4,8-sphingadiene (d18:2(delta4,delta8)) and alpha- hydroxypalmitic acid (h16:0); the remainder had the same backbone with h18:0, h20:0, h22:0 and h24:0 fatty acids. |
| M58559 | CY5-BSA | Cyanine5-Bovine Serum Albumin (CY5-BSA) is a fluorescent marker that labels the near-infrared fluorescent dye CY5 onto bovine serum albumin (BSA), which can be used for cell labelling, tissue imaging and in vivo imaging experiments. Due to the long wavelength property of CY5, it can penetrate biological tissues well and is suitable for imaging deep tissues, especially in small animal in vivo imaging. |
| M58558 | Nile Blue | Nile Blue A is highly fluorescent, and photostable organic dye used in biology and histology. And Nile Blue A is for use in lipid histochemistry. Nile blue A stains acidic components, such as phospholipids, nucleic and fatty acids by imparting a dark blue color, while neutral lipids, namely triglycerides, are stained pink, or red. Nile blue A is suitable for staining and discriminating between melanins and lipofuscins in paraffin sections of animal tissue, and in a histochemical method for lipids in frozen sections. |
| M58557 | Recombinant Human ACAA1 Protein (E. coli, N-His) | Recombinant Human ACAA1 Protein (E. coli, N-His) expressed the target gene encoding Gly182-Asn424 with an N-His tag. |
| M58556 | Recombinant Human ACAA2 Protein (E. coli, N-His) | Recombinant Human ACAA2 Protein (E. coli, N-His) expressed the target gene encoding Arg90-Ala397 with an N-His tag. |
| M58555 | Volociximab | Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC50=0.2 nM). Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs). |
| M58553 | Indoramin | Indoramin is a selective α1A-adrenoceptor antagonist. |
| M58552 | Recombinant Human Adrenomedullin Protein (HEK293, N-hFc) | Adrenomedullin is a a hypotensive peptide and has 1 intramolecular disulfide bond. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. |
| M58551 | Recombinant Human NQO-1 Protein (E. coli, N-His) | NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. |
| M58550 | Cy7.5 NHS ester | Cy7.5 NHS ester (Cyanine7.5 NHS ester) is a fluorescent dye. Cy7.5 NHS ester can be used for fluorescent imaging study. |
| M58548 | p-Cresol glucuronide | p-Cresol glucuronide is a metabolite of p-cresol, it is a prototype protein-bound uremic toxin. |
| M58545 | N-Hydroxypipecolic acid | N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection. |
| M58544 | Rotigaptide | Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP). |
| M58543 | Ro 363 hydrochloride | Ro 363 hydrochloride is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is also an effective inotropic stimulant. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility. |
| M58542 | P053 | P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC50 of 0.5 μM. P053 also acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle. |
| M58541 | VU0650786 | VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. |
| M58540 | Mitochondrial fusion promoter M1 | Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 (2 mg/kg; iv) alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury. |
| M58539 | AT 1001 | AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM. |
| M58538 | Sudoxicam | Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory agent from the enol-carboxamide class. |
| M58536 | Recombinant Mouse CD5L Protein (HEK293, C-6His) | CD5 Antigen-Like (CD5L) is a soluble protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily. CD5L regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram-negative bacteria and the SRCR domain one of CD5L retains both the LPS and LTA binding activities. |
| M58535 | Recombinant Human CD5L Protein (HEK293, C-6His) | CD5 Antigen-Like (CD5L) is a soluble protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily. CD5L regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram-negative bacteria and the SRCR domain one of CD5L retains both the LPS and LTA binding activities. |
| M58534 | NS-102 | NS-102 is a selective kainate (GluK2) receptor antagonist. |
| M58533 | Recombinant Human GAPDH Protein (E. coli, C-His) | GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58532 | Oleamide | Oleamide is an endogenous fatty acid amide. |
| M58531 | Deoxycarnitine chloride | Deoxycarnitine chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota. |
| M58530 | Benitrobenrazide | Benitrobenrazide (Hexokinase 2 inhibitor 1) is a hexokinase 2 (HK2) inhibitor with anticancer and antitumor activity. |
| M58529 | Recombinant Human Caspase-3 Protein (E. coli, N-His) | Caspase-3 protein is a thiol protease critical in apoptosis and is activated by initiating caspases (CASP8, CASP9 and/or CASP10). It catalyzes the cleavage of multiple proteins in sympathetic neurons, including PARP1, SREBP, caspase-6, -7 and -9, huntingtin, and RET. |
| M58528 | α-Glucosidase (from yeast) | α-Glucosidase is a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-glucosidase is used for the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters. It was also used in the measurement of glycosidase inhibition. |
| M58527 | 4-Acetoxy-3-methoxycinnamic acid | 4-Acetoxy-3-methoxycinnamic acid |
| M58525 | 5-Bromouridine | 5-Bromouridine is a purine nucleoside analog, with broad antitumor activity rely on inhibition of DNA synthesis, induction of apoptosis, etc. |
| M58524 | GDC-0927 | GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist. |
| M58523 | Monobutyl phthalate | Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. |
| M58522 | Peroxidase (Horseradish) | Peroxidase (Horseradish) involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases. |
| M58521 | Testosterone sulfate (pyridinium) | Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. |
| M58520 | RIP1/RIP3/MLKL activator 1 | RIP1/RIP3/MLKL activator 1 is a potent, blood-brain barrier permeable anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. |
| M58519 | K-80003 | K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. |
| M58517 | 2'-Deoxyinosine | 2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| M58516 | Lactate calcium | Lactate calcium is an excellent calcium fortifier that works better than inorganic calcium. Lactate calcium is used as an antacid. |
| M58515 | CDDO-TFEA | CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models. |
| M58513 | 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate | 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate is a fluorescent dye. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate can be used in the diagnosis of mucopolysaccharidosis IV A by detecting activity of galactose-6-sulphate sulphatase. |
| M58512 | λ-Carrageenan | λ-Carrageenan is a seaweed polysaccharide, it is a potent antitumor agent. λ-Carrageenan has been generally used as proinflammatory agent in the basic research. |
| M58510 | Recombinant Mouse GAPDH Protein (E. coli, N-His) | GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58507 | Recombinant Human Galectin-3 Protein (HEK293, C-His) | Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain. LGALS3 (Galectin 3) has an important role in tumor progression through inhibition of apoptosis. |
| M58506 | Coenzyme Q0 | Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. |
| M58504 | Cyclocreatine | Cyclocreatine acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. |
| M58502 | 4-Hydroxyestrone | 4-Hydroxyestrone (4-OHE1) is an estrone metabolite, it has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. |
| M58501 | Phentolamine | Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. |
| M58500 | EverFluor Fl C5-Ceramide | BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em= 505 nm/512 nm |
| M58499 | BODIPY TR Ceramide | BODIPY TR Ceramide (Golgi-Red Tracke) is a Golgi-specific fluorescent dye, which can visualise individual cells. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. Ex/Em=589 nm/616 nm |
| M58498 | SR-4995 | SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling. |
| M58492 | CS-6253 | CS-6253 is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles. |
| M58491 | Trypsin (bovine pancreas) | Trypsin is a serine protease in the digestive system of human and animals. The main function of this enzyme is to hydrolyze proteins into smaller peptides or even amino acids. |
| M58490 | Sulfo-Cy5.5 maleimide | Sulfo-Cy5.5 maleimide |
| M58489 | Cyanine5.5 maleimide | Cyanine5.5 maleimide |
| M58488 | Z-VAD | Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. |
| M58487 | NL-1 | NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50 values of 47.35 μM and 56.26 μM, respectively. |
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