| Cat.No. | Name | Information |
|---|---|---|
| M55398 | ER-Tracker Green | ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide, highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K+ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation. |
| M55397 | Recombinant Human HMGB1 Protein (E. coli) | High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. |
| M55395 | Patulin | Patulin (Terinin) is a mycotoxin produced by a variety of fungi, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage. |
| M55394 | T-2 Toxin | T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. |
| M55393 | DAR-2 | DAR-2 is a sensitive fluorescent NO probe. |
| M55392 | ZnAF-2 DA | ZnAF-2 DA is a fluorescent Zn2+ probe suitable for detection of Zn2+ (after esterase hydrolysis). |
| M55391 | ZnAF-1 | ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection. |
| M55390 | Fluorescein octadecyl ester | Fluorescein octadecyl ester is a Lipophilic fluorescent pH indicator. Fluorescein octadecyl ester is a lipophilic fluorescent reagent is immobilized in a plasticized PVC membrane. Fluorescein octadecyl ester can reversibly recognize alcohol molecules and can be used to determine the concentration of ethanol in alcoholic drinks. |
| M55389 | HPTS | HPTS is a fluorescent membrane-impermeant pH indicator. Ex: 460nm, Em: 510nm |
| M55388 | 2-Iminobiotin | 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. |
| M55387 | 2-Iminobiotin hydrobromide | 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. |
| M55386 | Glutathione monoethyl ester | Glutathione monoethyl ester is cell permeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. Glutathione monoethyl ester is a derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. |
| M55385 | DAR-1 | DAR-1 is a sensitive fluorescent NO probe. |
| M55384 | Dispase | Dispase is a neutral proteinase from microorganisms and is useful for cell isolation and tissue dissociation. |
| M55383 | N-Methylnicotinamide | N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherosclerosis by modulating the ADMA-DDAH axis. |
| M55382 | Recombinant Human IL-25/IL-17E (E. coli, C-His) | Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. |
| M55381 | Recombinant Human IL-25/IL-17E (Mammalian, C-6His) | Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. |
| M55380 | Recombinant Human SEMA3A (Mammalian, N-6His-Flag) | Semaphorin 3A (SEMA3A) is a secreted protein which belongs to the semaphorin family. Semaphorin 3A can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. |
| M55377 | 2-Bromo-2'-methoxyacetophenone | 2-Bromo-2'-methoxyacetophenone |
| M55376 | Gly-Pro-pNA hydrochloride | Gly-Pro-pNA hydrochloride is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX. Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors. |
| M55375 | Recombinant Human CD143/ACE (E. coli, N-GST) | CD143/ACE Protein is a recombinant human Angiotensin I-converting enzyme (ACE, CD143) which hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling. ACE plays a crucial role in blood pressure regulation, vascular remodeling, and immunity. |
| M55374 | Recombinant Human Neprilysin (Mammalian, N-8His) | Neprilysin/CD10 (MME; NEP) is a zinc metallopeptidase expressed at the cell surface of a variety of cells. Neprilysin/CD10 (MME) has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. |
| M55373 | Recombinant Human THOP1 (E.coli, C-6His) | Thimet Oligopeptidase (THOP1) is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. |
| M55372 | Ketodeoxynonulosonic acid | Ketodeoxynonulosonic acid (KDN; 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid) is a sialic acid, it protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish. |
| M55370 | Methyl Green | Methyl Green is a potent fluorescent dye. Methyl Green is a DNA stains of cells and electrophoretic gels. Methyl Green can be used as a stain for direct measuring of viability by both microscopy and flow cytometry, with peaks at 633 and 677 nm. |
| M55369 | Ammonium iron(II) sulfate | Ammonium iron(II) sulfate is an analytical reagent in titrations and colorimetric measurements to measure oxidizing substances, such as chlorine, or to measure the chemical oxygen demand in waste water. The compound is used to prepare Fe(II) standard solution for these analyses. It also is a calibration standard in magnetic measurements; a reducing agent; a catalyst for polymerization; and is used in photographic chemistry. |
| M55368 | 2-Hydroxy Fluorene | 2-Hydroxy Fluorene has a wide range of applications in life science related research. |
| M55367 | 2-Naphthol | 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). |
| M55366 | Isoluminol | Isoluminol (4-Aminophthalhydrazide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| M55365 | Apomorphine hydrochloride hemihydrate | Apomorphine hydrochloride hemihydrate is a dopamine D2 agonist. |
| M55364 | Recombinant Mouse IL-22 (Mammalian, C-mFc) | Interleukin-22 (IL-22) is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. |
| M55363 | IDE397 | IDE397 (GSK-4362676) is a potent, potential "first-in-class" inhibitor of methionine adenosyltransferase 2A (MAT2A). IDE397 (GSK-4362676) exhibits anti-tumor activity in MTAP-deleted PDX models. |
| M55362 | Recombinant Human REG4 Protein (Mammalian, C-6His) | Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP is a secreted contains one C-type lectin domain, high expressed in the gastrointestinal tract, including jejunum, ileum, appendix, pancreas and small intestine. In the acid environment, REG4 can maintain carbohydrate recognition activity. REG4 may be involved in inflammatory and metaplastic response of the gastrointestinal epithelium. |
| M55361 | Recombinant Mouse REG4 Protein (HEK293, His Tag) | Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP is a secreted contains one C-type lectin domain, high expressed in the gastrointestinal tract, including jejunum, ileum, appendix, pancreas and small intestine. In the acid environment, REG4 can maintain carbohydrate recognition activity. REG4 may be involved in inflammatory and metaplastic response of the gastrointestinal epithelium. |
| M55360 | 4-Methylumbelliferyl phosphate | 4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. |
| M55358 | Qingdainone | Qingdainone is a natural product that can be obtained from Qingdai. Qingdainone has the potential to study cancer and inflammation |
| M55357 | BMS-566394 | BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE). |
| M55356 | Bis-PEG2-acid | Bis-PEG2-acid (COOH-PEG1-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
| M55355 | Recombinant Mouse IGF-1 (E.coli, C-6His) | Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors. |
| M55354 | 2-aminoindan-2-phosphonic acid | 2-aminoindan-2-phosphonic acid |
| M55353 | Recombinant Human BMP-9 Protein (E. coli, His Tag) | Bone Morphogenetic Protein-9 (BMP-9), also known as Growth differentiation factor 2 (GDF2), is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-9/GDF-2 selectively signals through ACVRL1 in endothelial cells. Additionally, it engages in high-affinity interactions with ENG, forming a heterotetramer or a heteromeric complex with ENG and ACVRL1. |
| M55352 | 3-Chloro-L-tyrosine | 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and it is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. |
| M55351 | Recombinant Human IL-4 Protein (Mammalian) | Interleukin-4 (IL-4) regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. |
| M55350 | Recombinant Human IL-13 Protein (Mammalian, C-Fc) | Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. |
| M55349 | n-Dodecyl α-D-maltoside | n-Dodecyl α-D-maltoside is a nonionic detergent commonly used to solubilize integral membrane proteins and protein complexes. It has a critical micelle concentration (CMC) of 0.15 mM. n-Dodecyl α-D-maltoside has been used to solubilize photosystem I (PSI) and PSII complexes from plant thylakoid membranes, as well as intact grana. |
| M55348 | 5-(chloromethyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole | 5-(chloromethyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole |
| M55341 | Gliadin | Gliadin is a prolamin occurring in gluten, the protein of wheat, rye, and other grains. Gluten consists of two families of prolamins, known as gliadin and glutenin. Gliadin is a strongly hydrophobic glycoprotein, with a very poor solubility. The gliadins can be further subdivided into α-gliadins, γ-gliadins and ω-gliadins. |
| M55339 | Phosphotungstic acid | Phosphotungstic acid is a useful histology stain for cell specimens. |
| M55338 | Safflower Yellow | Safflower yellow is extracted from the flowers of the plant safflower (Carthamus tinctorius) and it has been extensively used for the research of cardio cerebrovascular diseases. |
| M55337 | (S)-Mephenytoin | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism. |
| M55336 | IL-4-inhibitor-1 | IL-4-inhibitor-1 is the first IL-4 small-molecule inhibitor, with an EC50 of 1.81 µM. IL-4-inhibitor-1 features a nicotinonitrile scaffold with micromolar affinity and potency for the cytokine and disrupts type II IL-4 signaling in cells. |
| M55335 | Coppersensor 1 | Coppersensor-1 is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu+ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu+) in biological samples, including live cells. |
| M55334 | Tanshinol B | Tanshinol B is a bioactive component of Salvia miltiorrhiza, which can be isolated from the 50% ethanol extract of the roots and rhizomes of Seaweed prowazekii. |
| M55333 | Recombinant Mouse GDF15 (Mammalian, N-8His-Flag) | Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenitors and introduced as a putative placental mediator of embryonic development. |
| M55332 | N-Chlorosuccinimide | N-Chlorosuccinimide (NCS) is a chlorinating and oxidizing reagent. It is more efficient when compared to other chlorinating agents, such as 1,3-dichloro-5,5-dimethylhydantoin (NDDH) and trichloroisocyanuric acid (TCCA) due to its high regioselectivity. |
| M55331 | ICG-amine | ICG-amine (ICG-NH2) is a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. |
| M55328 | 3-Hydroxypropionic acid sodium salt | 3-Hydroxypropionic acid sodium salt is a building block in the synthesis of a variety of compounds with industrial applications. 3-Hydroxypropionic acid sodium salt can be used to synthesize some degradable plastics and produce a series of C3 compounds. |
| M55327 | Recombinant Mouse CX3CL1 Protein (Mammalian, C-6His) | C-X3-C motif Chemokine 1 (CX3CL1; Fractalkine) is a single-pass type I membrane protein which belongs to the intercrine delta family. The protein may play a role in regulating leukocyte adhesion and migration processes at the endothelium. |
| M55326 | JG-2016 | JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC50 of 14.8 μM in the HAT1 acetylation assays. |
| M55325 | Recombinant Human IL-29/IFN-λ1 (Mammalian, C-10His) | Interleukin-29 (IL-29; IFN-λ1) is a cytokine with immunomodulatory activity. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. |
| M55324 | N-Oxalylglycine | N-Oxalylglycine (N-Oxaloglycine) is a broad-spectrum 2-oxoglutarate oxygenase inhibitor. |
| M55323 | JBH492 | JBH492 is a first-in-class (C-C chemokine receptor 7) CCR7-targeting ADC, comprising a humanized, Fc-silenced anti-CCR7 IgG1 antibody conjugated to maytansinoid microtubule inhibitor DM4 via a cleavable linker. |
| M55322 | LY3471851 | LY3471851 (Rezpegaldesleukin, NKTR-358) is a novel, first-in-class selective regulatory T-cell (Treg) inducing IL-2 conjugate. |
| M55321 | Filanesib hydrochloride | Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. |
| M55320 | MP7 | MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor. |
| M55319 | Saccharin sodium | Saccharin sodium is the first generation synthetic sμgar alternative that has been studied for its carcinogenic potential. |
| M55318 | Dulcin | Dulcin (DL), 4-ethoxyphenylurea, a synthetic chemical about 200 times as sweet as sucrose, has been proposed for use as an artificial sweetener. |
| M55317 | IA9 TFA | IA9 TFA is a TREM-2 inhibitor. IA9 TFA and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model. |
| M55316 | SPD-473 citrate | SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. SPD-473 inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor potentially for the research of Parkinson's Disease. |
| M55314 | Recombinant Mouse Decorin Protein (Mammalian, C-6His) | Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. |
| M55313 | Recombinant Human Decorin Protein (HEK293) | Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. |
| M55312 | Recombinant Human Decorin Protein (Mammalian, C-6His) | Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. |
| M55311 | Mitoguazone | Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. |
| M55310 | BI 1291583 | BI 1291583 is a novel selective inhibitor of cathepsin C (CatC; DPP1). BI 1291583 bound human CatC (DPP1) in a covalent, reversible manner, selectively and fully inhibiting CatC enzymatic activity. |
| M55309 | Total flavonoids from Astragali radix | Total flavonoids from Astragali radix are the main active components isolated from Astragalus, which have a variety of biological effects such as antioxidant, scavenging free radicals, anti-injury, anti-mutagenesis, anti-tumor and inhibition of atherosclerosis. |
| M55308 | ARTS-021 | ARTS-021 is a potent, reversible, orally available cyclin-dependent kinase 2 (CDK 2) selective inhibitor that inhibits CDK2 at nanomolar potency and with over 600-fold selectivity against CDK1. |
| M55307 | Recombinant Human TIM-4 Protein (Mammalian, C-6His) | T-cell Immunoglobulin and Mucin Domain-containing Protein 4(TIM-4) belongs to the immunoglobulin superfamily. TIM-4 is expressed by macrophages and mature dendritic cells but not by lymphocytes. it is Involved in regulating T-cell proliferation and lymphotoxin signaling. |
| M55306 | Guanosine 3′,5′-cyclic monophosphate | Guanosine 3′,5′-cyclic monophosphate (cGMP) acts as an important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG). |
| M55305 | HJC0123 | HJC0123 is a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs. HJC0123 reduced the phosphorylation, nuclear translocation, and transcriptional activity of STAT3. HJC0123 treatment resulted in the inhibition of HSCs proliferation at submicromolar concentrations. It decreased the expression of STAT3-regulated proteins, induced cell cycle arrest, promoted apoptosis and downregulated SOCS3. |
| M55304 | ODZ10117 | ODZ10117 is a small molecule inhibitor of STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells. |
| M55302 | Myosin H Chain Fragment, mouse acetate | Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model. |
| M55301 | Myosin H Chain Fragment, mouse | Myosin H Chain Fragment, mouse is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model. |
| M55300 | Menaquinone-7 | Menaquinone-7 (Vitamin K2-7) belongs to a class of K2-vitamin homologs (orally active), it is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2, MK-7) inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. |
| M55299 | Recombinant Human FLT3L (Mammalian, C-6His) | Fms-like Tyrosine Kinase 3 Ligand (FLT3L) is a hematopoietic four helical bundle cytokine. Flt‑3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts. |
| M55298 | OPB-111077 | OPB-111077 is a first-in-class, novel, oral inhibitor of STAT3 and mitochondrial oxidative phosphorylation (OXPHOS) with anticancer activity. OPB-111077 inhibits mitochondrial respiratory chain complex I, which leads to inhibition of energy production and activation of the AMPK-mTOR energy stress sensor pathway. |
| M55297 | OPB-31121 | OPB-31121 is a novel STAT inhibitor which strongly inhibited STAT3 and STAT5 phosphorylation without upstream kinase inhibition, and induced significant growth inhibition in various hematopoietic malignant cells. |
| M55296 | VVD-214 | VVD-214 (RO7589831) is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. |
| M55294 | Cholesterol hemisuccinate Tris salt | Cholesteryl Hemisuccinate Tris Salt is a cholesterol analogue with hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate Tris Salt inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. |
| M55293 | Recombinant Mouse RANKL (E. coli) | RANKL is a member of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. Tnfsf11 is involved in many fundamental biological processes, such as acting as a regulator of interactions between T cells and dendritic cells, regulating T cell-dependent immune responses and enhancing bone resorption in malignant humoral hypercalcemia. It enhances the ability of dendritic cells to stimulate the proliferation of naive T cells. |
| M55292 | Zinquin | Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Excitation (nm) 355, Emission (nm) 491 |
| M55291 | Adenosylcobalamin | Adenosylcobalamin (Coenzyme B12; Cobamamide; AdoCbl) is an active form of Vitamin B12 which is a cofactor for methylmalonyl CoA mutase. |
| M55259 | IRDye 800 NHS | IRDye 800 NHS is an active ester that can be used to label biomolecules, such as proteins and nucleic acids, in order to track and detect the dynamic behavior of these molecules in molecular biology research. IRDye 800CW NHS has good water solubility and can be bound to biomolecules, and the biomolecules still maintain their original biological activity after binding. |
| M55258 | THP104c | THP104c is a mitochondrial fission inhibitor. |
| M55255 | APVO603 | APVO603 is a dual agonist bispecific antibody employing a novel mechanism of action to simultaneously target 4-1BB (CD137) and OX40 (CD134), both members of the TNF-receptor family. |
| M55254 | STAR-0310 | STAR-0310 is a novel OX40 antagonistic monoclonal antibody which has a potential best-in-class profile with a high affinity, potential for favorable safety and tolerability profile with low T cell depletion from ADCC or possible on-target cellular toxicity. |
| M55253 | SL-279252 | SL-279252 (PD1-Fc-OX40L) is a hexameric, bi-functional fusion protein with an ECD of PD-1 (70 pM affinity to PD-L1) linked to the ECD of OX40L (324 pM affinity for OX40) through an Fc linker. SL-279252 exhibited linear PK at doses up to 3.0 mg/kg, and a greater than proportional increase in AUC was observed at 6.0 mg/kg suggesting potential receptor saturation. The preliminary half-life is approximately 23 hours. |
| M55252 | FS120 | FS120 is a first-in-class dual-agonist tetravalent bispecific antibody targeting CD137 (4-1BB, TNFRSF9) and OX40 (CD134, TNFRSF4). FS120 has the potential to show activity in "cold" tumors and improve outcomes of existing immunotherapies by simultaneously agonizing CD137 and OX40. |
| M55251 | ATOR-1015 | ATOR-1015 is a human CTLA-4 x OX40 targeting IgG1 bispecific antibody with enhanced immune activation and tumor-directed activity for improved efficacy and reduced toxicity. ATOR-1015 induces T-cell activation and Treg depletion in vitro. |
| M55250 | YH002 | YH002 is a recombinant anti-OX40 (CD134, TNFRSF4) humanized IgG1 agonistic antibody. |
| M55249 | HFB 3010 | HFB 3010 (HFB 301001) is a novel second-generation fully human IgG1 class OX40 agonistic monoclonal antibody. |
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