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FASN-IN-4 tosylate

Cat. No. M14432
FASN-IN-4 tosylate Structure
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Biological Activity

FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.

Chemical Information
Molecular Weight 649.78
Solubility (25°C) DMSO 12.5 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kunal Maini, et al. Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia

[2] Gabriela Wiergowska, et al. Structural Polymorphism of Sorafenib Tosylate as a Key Factor in Its Solubility Differentiation

[3] Rong Sun, et al. Simultaneous Determination of Nine Residual Solvents in Sorafenib Tosylate by Gas Chromatography

[4] Yvette N Lamb. Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis: A Profile of Its Use

[5] No authors listed. Edoxaban tosylate

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