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About 30 results found for searched term "FAS" (0.022 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1872 | Fasudil hydrochloride | Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. |
| M2019 | Go 6983 | Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor. |
| M2054 | Fasiglifam (TAK-875) Hemihydrate | Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist. |
| M2197 | Sulfasalazine | Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. |
| M2604 | C75 | C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). |
| M2606 | Tirasemtiv | Tirasemtiv is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with aging, muscle weakness and wasting or neuromuscular dysfunction. |
| M3441 | Clorsulon | Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep. |
| M3607 | Fasudil | Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| M3865 | L-Buthionine-sulfoximine | L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination. |
| M4643 | Albaspidin-AP | Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity. |
| M5260 | Hydroxyfasudil hydrochloride | Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. |
| M5421 | Artemotil | Artemotil (β-Arteether) is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. |
| M5905 | Propoxur | Propoxur is a carbamate insecticide with a fast knockdown and long residual effect used against turf, forestry, and household pests and fleas. |
| M6738 | G 28UCM | G 28UCM is a fASN inhibitor. |
| M7532 | KR-33493 | KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1). |
| M7771 | Phenoxodiol | Phenoxodiol is a synthetic genestein analogue that activates the mitochondrial caspase system and inhibits XIAP, an inhibitor of apoptosis, making cancer cells sensitive to FAS - mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing cleavable complexes, thereby preventing DNA replication. |
| M7805 | Fasentin | Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. |
| M8303 | Azimilide dihydrochloride | Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. |
| M8484 | GSK2194069 | GSK2194069 is a fatty acid synthase (FAS) inhibitor. |
| M8613 | CDN1163 | CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. |
| M8622 | TVB-3166 | TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. |
| M9508 | C75 trans | C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor. |
| M9897 | GB1107 | GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules. |
| M10175 | TVB-3664 | TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression. |
| M10300 | Thymosin alpha 1 | Thymosin alpha 1 (Thymalfasin) is an immunomodulating agent able to enhance the Thl immune response. |
| M10389 | Aminoethoxyvinyl glycine hydrochloride | Aminoethoxyvinyl glycine hydrochloride is an ethylene synthesis inhibitor. It is used to study the roles of ethylene in plant processes such as gravitropism and fasciation/cresting. |
| M10694 | INE963 | INE963 is an oral, single-dose, fast-acting blood-stage antimalarial candidate with an EC50 value of 3-6 nM. |
| M10746 | Denifanstat | Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research. |
| M11156 | Nuclear fast red | Light purple on sodium hydroxide, brown in sulfuric acid solution. Soluble in ethanol and water. Maximum absorption wavelength 518nm. Irritating. It can be used for nucleus staining of connective tissue and determination of calcium in serum. |
| M13728 | Hydroxyfasudil | Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. |
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