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 About 30 results found for searched term "FAS" (0.022 seconds)

Cat.No.  Name Information
M1872 Fasudil hydrochloride Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM.
M2019 Go 6983 Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor.
M2054 Fasiglifam (TAK-875) Hemihydrate Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist.
M2197 Sulfasalazine Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent.
M2604 C75 C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS).
M2606 Tirasemtiv Tirasemtiv is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with aging, muscle weakness and wasting or neuromuscular dysfunction.
M3441 Clorsulon Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.
M3607 Fasudil Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
M3865 L-Buthionine-sulfoximine L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.
M4643 Albaspidin-AP Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity.
M5260 Hydroxyfasudil hydrochloride Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.
M5421 Artemotil Artemotil (β-Arteether) is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases.
M5905 Propoxur Propoxur is a carbamate insecticide with a fast knockdown and long residual effect used against turf, forestry, and household pests and fleas.
M6738 G 28UCM G 28UCM is a fASN inhibitor.
M7532 KR-33493 KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
M7771 Phenoxodiol Phenoxodiol is a synthetic genestein analogue that activates the mitochondrial caspase system and inhibits XIAP, an inhibitor of apoptosis, making cancer cells sensitive to FAS - mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing cleavable complexes, thereby preventing DNA replication.
M7805 Fasentin Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor.
M8303 Azimilide dihydrochloride Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels.
M8484 GSK2194069 GSK2194069 is a fatty acid synthase (FAS) inhibitor.
M8613 CDN1163 CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice.
M8622 TVB-3166 TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.
M9508 C75 trans C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor.
M9897 GB1107 GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.
M10175 TVB-3664 TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.
M10300 Thymosin alpha 1 Thymosin alpha 1 (Thymalfasin) is an immunomodulating agent able to enhance the Thl immune response.
M10389 Aminoethoxyvinyl glycine hydrochloride Aminoethoxyvinyl glycine hydrochloride is an ethylene synthesis inhibitor. It is used to study the roles of ethylene in plant processes such as gravitropism and fasciation/cresting.
M10694 INE963 INE963 is an oral, single-dose, fast-acting blood-stage antimalarial candidate with an EC50 value of 3-6 nM.
M10746 Denifanstat Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research.
M11156 Nuclear fast red Light purple on sodium hydroxide, brown in sulfuric acid solution. Soluble in ethanol and water. Maximum absorption wavelength 518nm. Irritating. It can be used for nucleus staining of connective tissue and determination of calcium in serum.
M13728 Hydroxyfasudil Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

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