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Thymosin alpha 1

Cat. No. M10300
Thymosin alpha 1 Structure
Synonym:

Thymosin α1; Thymalfasin

Size Price Availability Quantity
500ug USD 90  USD90 In stock
1mg USD 150  USD150 In stock
5mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

Thymosin alpha 1 (Thymalfasin) is an immunomodulating agent able to enhance the Thl immune response.

Chemical Information
Molecular Weight 3108.28
Formula C129H215N33O55
CAS Number 62304-98-7
Solubility (25°C) Water 0.3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xingzhen Lao, et al. Apoptosis. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects

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Keywords: Thymosin alpha 1, Thymosin α1; Thymalfasin supplier, Peptides, inhibitors, activators


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