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COVID-19 Related Inhibitors and Antibodies

Cat.No. Product Name Target
M6166 Bevacizumab VEGFR/PDGFR
Humanized vascular endothelial growth factor (VEGF) antibody (bevacizumab; Avastin) is a highly effective monoclonal antibody against metastatic colorectal cancer and several other advanced late stage cancers.
M6223 Tocilizumab Immunology/Inflammation
MRA; atlizumab
Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.
M6222 Adalimumab TNF-alpha
LU200134, D2E7
Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
M3864 Remdesivir Anti-infection
Remdesivir, also known as GS-5734, is a nucleoside analogue with in vitro activity against multiple RNA viruses, including Ebola and CoV.
M2510 Chloroquine diphosphate Autophagy
Chloroquine Phosphate
Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M5159 Hydroxychloroquine Sulfate Autophagy
HCQ sulfate
Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
M5438 Azithromycin Anti-infection
CP 62993
Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
M6094 Darunavir HIV Protease
TMC114; TMC-114; TMC 114
Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.
M1959 Oseltamivir Anti-infection
Oseltamivir is a potent and selective inhibitor of influenza virus neuraminidase enzyme.
M3334 Ribavirin Anti-infection
Ribavirin (Copegus) is an anti-viral agent indicated for severe RSV infection (individually), hepatitis C infection and other viral infections.
M5053 Arbidol hydrochloride Anti-infection
Umifenovir hydrochloride
Arbidol hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.
M2487 Camostat Mesilate Others
FOY-305; Camostat mesylate
Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
M5803 Nafamostat Mesylate Others
Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis.
M6264 Favipiravir DNA/RNA Synthesis
Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
M2159 Ritonavir HIV Protease
Ritonavir (ABT-538) is an HIV protease inhibitor used frequently as a booster of other protease inhbitors.
M9113 Bictegravir Integrase
Bictegravir (GS-9883) is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
M2158 Lopinavir HIV Protease
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM.
M3568 Darunavir Ethanolate HIV Protease
Darunavir Ethanolate is an HIV protease inhibitor.
M4824 Dolutegravir sodium HIV Protease
GSK-1349572A, DTG
Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.
M3468 Methylprednisolone Immunology/Inflammation
U 7532
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
M2225 Thalidomide TNF-alpha
Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.
M2328 Pirfenidone TGF-beta/Smad
Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.
M1831 Cyclosporine A Immunology/Inflammation
Cyclosporine A is a powerful immunosuppressive agent that inhibits the T-cell receptor signal transduction pathway.
M1787 INCB18424 JAK
INCB18424 is a potent inhibitor of both JAK1 and JAK2 with selectivity versus JAK3 and TYK2 (IC50 values of 2.7, 4.5, 332, and 19 nM, respectively, in biochemical assays).
M2152 Carfilzomib Proteasome
Carfilzomib (PR-171) is a novel and selective, irreversible proteasome inhibitor with IC50 of <5 nM.
M1712 FTY720 Src-bcr-Abl
FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M1701 Dasatinib Src-bcr-Abl
Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively.
M3380 Pitavastatin Calcium Autophagy
Pitavastatin hemicalcium; NK-104
Pitavastatin calcium is a novel member of the medication class of statins.
M3241 Imatinib c-Kit
Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
M3493 Mitoxantrone Topoisomerase
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.
M2283 Rosuvastatin calcium Autophagy
Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M3624 Boceprevir HCV Protease
EBP-520, SCH503034
Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
M3433 Nitazoxanide Others
NTZ; NSC 697855
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM).
M2256 Ivermectin Autophagy
Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor.
M3121 Vitamin C Vitamin
Ascorbic acid
Vitamin C is a water-soluble vitamin indicated for the prevention and treatment of scurvy.

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