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Pitavastatin Calcium

Cat. No. M3380
Pitavastatin Calcium Structure

Pitavastatin hemicalcium; NK-104

Size Price Availability Quantity
10mg USD 50  USD50 In stock
25mg USD 75  USD75 In stock
50mg USD 110  USD110 In stock
100mg USD 175  USD175 In stock
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Quality Control & Documentation
Biological Activity

Pivastatin calcium (Livalo) is a new member of the statin group. Like other statins, it is an inhibitor of hmG-COA reductase, an enzyme that catalyzes the first step in cholesterol synthesis. Most statins are metabolized in part by one or more liver cytochrome P450 enzymes, leading to an increased likelihood of complex interactions and problems with certain foods, such as grapefruit juice. Pivastatin appears to be a substrate for CYP2C9, rather than CYP3A4(a common source of interactions with other statins).

Product Citations
Customer Product Validations & Biological Datas
Source Pak J Pharm Sci (2016). Figure 1. Pitavastatin calcium (Abmole Bioscience)
Method HPLC chromatogram
Cell Lines
Concentrations 80μg/ml
Incubation Time
Results The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.
Chemical Information
Molecular Weight 880.98
Formula C50H46CaF2N2O8
CAS Number 147526-32-7
Solubility (25°C) DMSO 49 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Junying Wang, et al. Simultaneous Determination of Telmisartan and Pitavastatin Calcium in Intestinal Perfusate by HPLC: Application to Intestinal Absorption Interaction Study

[2] Paul Chan, et al. An evaluation of pitavastatin for the treatment of hypercholesterolemia

[3] Laurie L Yee, et al. Pitavastatin calcium: clinical review of a new antihyperlipidemic medication

[4] Keijiro Saku, et al. Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial

[5] R Y A Mukhtar, et al. Pitavastatin

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Keywords: Pitavastatin Calcium, Pitavastatin hemicalcium; NK-104 supplier, Autophagy, inhibitors, activators

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