Catalog

Autophagy Autophagy

Inhibitors

Cat.No.	Name	Information
M10546	Indophagolin	Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
M10277	EN6	EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
M10257	Glycycoumarin	Glycycoumarin is a bioactive coumarin of licorice, it inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway.
M10165	TPEN	TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
M10087	Ginkgolide K	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
M9851	GW406108X	GW406108X is a potent autophagy inhibitor, with a pIC50 6.37 (427 nM) against ULK1.
M9702	QX77	QX77 is a novel chaperone-mediated autophagy (cma) activator.
M9610	LC3-mHTT-IN-AN1	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound, interacts with both mutant huntingtin protein (mHTT) and LC3B.
M9559	Chloroquine	Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis, it is also a autophagy and toll-like receptors (TLRs) inhibitor.
M9457	Lanatoside C	Lanatoside C is a cardiac glycoside, with IC50 of 0.19 μM for dengue virus infection in HuH-7 cells.
M9451	Curcumin analog C1	Curcumin analog C1 is a potent, orally effective transcription factor EB (TFEB) activator and is a potential therapeutic agent for the treatment of neurodegenerative diseases.
M9155	Autophinib	Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin with IC50 values of 90 and 40 nM, targeting the lipid kinase VPS34 with IC50 value of 19 nM in vitro.
M9092	Hemin chloride	Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis.
M9069	AS1842856	AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.
M9059	TBHQ	TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator.
M8783	Lys05	Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15.
M8617	3BDO	3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway.
M8391	Icaritin	Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway.
M7546	SMER 28	SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
M7542	SBC-115076	SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Target: PCSK9 in vivo: SBC-115076 lowers cholesterol levels in mice that are fed high fat diet.
M6293	Tacrolimus monohydrate	Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer.
M6260	ROC-325	ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.
M6255	JPH203	JPH203, a selective L-type amino acid transporter 1 (LAT1) inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
M6194	Esomeprazole Magnesium trihydrate	Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
M6097	Corynoxine	Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
M6086	SBI-0206965	SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .
M5961	Silibinin	Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
M5714	Isosorbide Mononitrate	Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.
M5649	Flubendazole	Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
M5196	Spautin-1	Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.
M5159	Hydroxychloroquine Sulfate	Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
M5143	Stenabolic (SR9009)	Stenabolic (SR9009) is an agonist of REV-ERB, with IC50 of 670 nM and 800 nM for REV-ERBα and REV-ERBβ respectively.
M4844	Isobavachalcone	Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma.
M4702	Corosolic acid	Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa, has antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity.
M4585	Taxifolin (TFN)	Taxifolin (TFN) is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM.
M4552	Nobiletin	Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.
M4522	Ursolic-acid	Ursolic-acid
M3921	Dioscin	Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.
M3699	Letrozole	Letrozole is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
M3690	Mefloquine hydrochloride	Mefloquine hydrochloride is a quinoline antimalarial inhibitor that is structurally related to the antiarrhythmic agent quinidine.
M3510	Mifepristone	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.
M3499	Ezetimibe	Ezetimibe (Zetia) is a compound that lowers cholesterol.
M3497	Simvastatin	Simvastatin is a competitive inhibitor of HMG-CoA reductase with K_i of 0.1-0.2 nM .
M3422	Capsaicin	Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum.
M3380	Pitavastatin Calcium	Pitavastatin calcium is a novel member of the medication class of statins.
M3327	Genipin	Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.
M3292	Adenosine	Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
M3291	Hydroxyurea (NSC-32065)	Hydroxyurea (NSC-32065) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
M3120	Vinorelbine Tartrate	Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.
M3104	UNC0638	UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets.

Signaling Pathways

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Autophagy Autophagy

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