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Autophagy Autophagy


Cat.No.  Name Information
M1934 Tacrolimus (FK506) Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended
M2283 Rosuvastatin calcium Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M3380 Pitavastatin Calcium Pitavastatin Calcium is a new type of statin.
M3497 Simvastatin Simvastatin (Zocor) is a competitive inhibitor of HMG-COA reductase with K I of 0.1-0.2 nM. Simvastatin inhibits exosome release.
M2510 Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M19865 Sulfacetamide sodium salt hydrate Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
M15099 Tat-beclin 1 Tat-beclin 1, a Beclin 1-derived peptide, is an effective inducer of autophagy and can stimulate autophagy by mobilizing endogenous Beclin 1. Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr
M13571 Trimetazidine Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA).
M13570 Sophocarpine Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory.
M13569 S29434 S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1.
M13568 Liensinine Diperchlorate Liensinine Diperchlor​ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn.
M13567 Leonurine hydrochloride Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.
M13566 Isorhapontigenin Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation.
M13565 Hoechst 33342 trihydrochloride Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain.
M13564 FMK 9a FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay.
M13563 AC-73 AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways.
M13562 20-Deoxyingenol 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui.
M11502 Hydroquinone Hydroquinone is an inhibitor and antioxidant used as a synthetic intermediate in dyes, engine fuels, and oils. It also has antioxidant properties and produces toxic effects in multiple organs, especially the kidneys.
M11327 ABTL-0812 Abtl-0812 (α -hydroxylinoleic acid) induces ER stress-mediated autophagy and has anticancer activity.
M11298 Oleanolic Acid Oleanolic Acid (Oleanic Acid) is a natural compound with anticancer activity, widely distributed in edible and medicinal plants. It is related to betulinic Acid and has relatively non-toxic, anti-tumor, hepatoprotective and antiviral properties.
M11124 Corynoxine B Corynoxine B is a natural compound of indole alkaloid, a beclin-1-dependent autophagy inducer.
M11037 Cearoin Cearoin enhances autophagy and induces apoptosis by promoting ROS production and activating ERK.
M10988 Bergenin Bergenin is a cell protection and antioxidant polyphenol found in many medicinal plants. Bergenin has a wide range of hepatoprotective, anti-inflammatory, immunomodulatory, anti-tumor, antiviral, and antifungal effects.
M10731 ICCB-19 hydrochloride ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds to the N-terminal domain of TRADD (TRADD-N), breaking its binding to TRADD-C and TRAF2. ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and degradation of long-lived proteins.
M10546 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.

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