| Cat.No. | Name | Information |
|---|---|---|
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M6255 | JPH203 | JPH203, a selective L-type amino acid transporter 1 (LAT1) inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M4124 | 6-Shogaol | Shogaol ([6]-Shogaol) is an active substance isolated from ginger and has a variety of biological activities, including anti-cancer, anti-inflammatory and antioxidant activities. |
| M3510 | Mifepristone | Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M22238 | Emetine dihydrochloride hydrate | Emetine dihydrochloride hydrate |
| M20648 | DC661 | DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). |
| M20551 | CA-5f | CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. |
| M19865 | Sulfacetamide sodium salt hydrate | Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. |
| M18477 | Notoginsenoside Fc | Notoginsenoside Fc is a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy. |
| M15099 | Tat-beclin 1 | Tat-beclin 1, a Beclin 1-derived peptide, is an effective inducer of autophagy and can stimulate autophagy by mobilizing endogenous Beclin 1. Sequence：Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr |
| M13575 | Sulfosuccinimidyl oleate sodium | Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. |
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