Inhibitors
Cat.No. | Name | Information |
---|---|---|
M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
M2283 | Rosuvastatin calcium | Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. |
M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
M3497 | Simvastatin | Simvastatin (Zocor) is a competitive inhibitor of HMG-COA reductase with K I of 0.1-0.2 nM. Simvastatin inhibits exosome release. |
M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
M19865 | Sulfacetamide sodium salt hydrate | Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. |
M15099 | Tat-beclin 1 | Tat-beclin 1, a Beclin 1-derived peptide, is an effective inducer of autophagy and can stimulate autophagy by mobilizing endogenous Beclin 1. Sequence:Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr |
M13571 | Trimetazidine | Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). |
M13570 | Sophocarpine | Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. |
M13569 | S29434 | S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. |
M13568 | Liensinine Diperchlorate | Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. |
M13567 | Leonurine hydrochloride | Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. |
M13566 | Isorhapontigenin | Isorhapontigenin, an orally bioavailable dietary polyphenol isolated from the Chinese herb Gnetum cleistostachyum, displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation. |
M13565 | Hoechst 33342 trihydrochloride | Hoechst 33342 trihydrochloride is a membrane permeant blue fluorescent DNA stain. |
M13564 | FMK 9a | FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. |
M13563 | AC-73 | AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. |
M13562 | 20-Deoxyingenol | 20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. |
M11502 | Hydroquinone | Hydroquinone is an inhibitor and antioxidant used as a synthetic intermediate in dyes, engine fuels, and oils. It also has antioxidant properties and produces toxic effects in multiple organs, especially the kidneys. |
M11327 | ABTL-0812 | Abtl-0812 (α -hydroxylinoleic acid) induces ER stress-mediated autophagy and has anticancer activity. |
M11298 | Oleanolic Acid | Oleanolic Acid (Oleanic Acid) is a natural compound with anticancer activity, widely distributed in edible and medicinal plants. It is related to betulinic Acid and has relatively non-toxic, anti-tumor, hepatoprotective and antiviral properties. |
M11124 | Corynoxine B | Corynoxine B is a natural compound of indole alkaloid, a beclin-1-dependent autophagy inducer. |
M11037 | Cearoin | Cearoin enhances autophagy and induces apoptosis by promoting ROS production and activating ERK. |
M10988 | Bergenin | Bergenin is a cell protection and antioxidant polyphenol found in many medicinal plants. Bergenin has a wide range of hepatoprotective, anti-inflammatory, immunomodulatory, anti-tumor, antiviral, and antifungal effects. |
M10731 | ICCB-19 hydrochloride | ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds to the N-terminal domain of TRADD (TRADD-N), breaking its binding to TRADD-C and TRAF2. ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and degradation of long-lived proteins. |
M10546 | Indophagolin | Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
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