| Cat.No. | Name | Information |
|---|---|---|
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M8391 | Icaritin | Icaritin (Anhydroicaritin) is a flavonoid derivative of isoprene from Epimedium Genusis. It effectively inhibited the proliferation of K562 cells (IC50 8 µM) and primary CML cells (IC50 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3/AKT signaling and enhance osteogenesis. |
| M8189 | STF-62247 | Stf-62247 is an autophagy inducer with selective cytotoxicity against VHL-deficient renal cell carcinoma, with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. Stf-62247 can trigger ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. |
| M7690 | ML-9 | ML-9 is a potent, selective Akt kinase inhibitor that inhibits myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. It acts on MLCK, PKA and PKC with Ki values of 4, 32 and 54 μM, respectively. In addition, ML-9 induces autophagy by stimulating the formation of autophagosomes and inhibiting their degradation. |
| M7546 | SMER 28 | SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide. |
| M7317 | Spermidine trihydrochloride | Spermidine trihydrochloride is a agonist at polyamine site. |
| M6260 | ROC-325 | ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM. |
| M6194 | Esomeprazole Magnesium trihydrate | Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. |
| M6097 | Corynoxine | Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. |
| M5975 | Sulfabenzamide | Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis. |
| M5954 | Selenomethionine | Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium. |
| M5911 | Pyriproxyfen | Pyriproxyfen is a juvenile hormone analog, preventing larvae from developing into adulthood and thus rendering them unable to reproduce. Pyriproxyfen is a pyridine-based pesticide which is found to be effective against a variety of arthropoda. |
| M5824 | Nortriptyline hydrochloride | Nortriptyline hydrochloride is a tricyclic antidepressant used to relieve the symptoms of depression. |
| M5820 | Nitroprusside disodium dihydrate | Nitroprusside disodium dihydrate is a nitric oxide (NO) donor that induces the release of NO into the bloodstream and induces autophagy in glutathione-depleted osteoblasts. |
| M5714 | Isosorbide Mononitrate | Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure. |
| M5649 | Flubendazole | Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection. |
| M5380 | Aceglutamide | Aceglutamide is a precursor compound to glutamine that improves nerve cell metabolism. |
| M5196 | Spautin-1 | Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. |
| M5159 | Hydroxychloroquine Sulfate | Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9. |
| M4844 | Isobavachalcone | Isobavachalcone(Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. |
| M4760 | Pterostilbene | Pterostilbene is an antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. |
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