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ML-9

Cat. No. M7690
ML-9 Structure
Size Price Availability Quantity
10mg USD 66  USD66 In stock
25mg USD 130  USD130 In stock
50mg USD 190  USD190 In stock
100mg USD 285  USD285 In stock
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Quality Control & Documentation
Biological Activity

ML-9 is a potent, selective Akt kinase inhibitor that inhibits myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. It acts on MLCK, PKA and PKC with Ki values of 4, 32 and 54 μM, respectively. In addition, ML-9 induces autophagy by stimulating the formation of autophagosomes and inhibiting their degradation.

Chemical Information
Molecular Weight 361.29
Formula C15H17N2O2SCl · HCl
CAS Number 105637-50-1
Solubility (25°C) ethanol 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniela Ribeiro, et al. Calcium Pathways in Human Neutrophils-The Extended Effects of Thapsigargin and ML-9

[2] A Kondratskyi, et al. Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death

[3] Satoru Ito, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis

[4] G Inoue, et al. Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes

[5] T Ishikawa, et al. ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation

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Keywords: ML-9 supplier, Autophagy, inhibitors, activators


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