About 31 results found for searched term "Autophagy" (0.051 seconds)
|Autophagy enhancer-99 hydrobromide
|AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 (hydrobromide) crosses the blood-brain barrier and exerts potent neuroprotective effects.
|AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator.
|Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis.
|Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy.
|ICI 182780; ZD 9238; ZM 182780
|Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect.
|2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa.
|Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
|Dorsomorphin (Compound C) dihydrochloride
|BML-275 2HCl; Compound C 2HCl
|Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy.
|BFA; Cyanein; Decumbin
|Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.
|Dexamethasone Sodium Phosphate
|Dexamethasone phosphate disodium
|Dexamethasone Sodium Phosphate is a glucocorticoid receptor agonist that induces the production of lipocortin, a phospholipase A2 inhibitory protein. Dexamethasone inhibits autophagy levels in damaged cells in a dose-dependent manner. It can be used to construct models of allergic conjunctivitis.
|NSC 303580, PFTμ
|Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
|Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy.
|Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro.
|Simvastatin (MK 733)
|MK 733; MK-0733
|Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
|Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
|Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury.
|Verteporfin (CL 318952)
|CL 318952; BPD-MA
|Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy.
|Ginsenoside F2, a metabolite of Ginsenoside Rb1, induces apoptosis and protective autophagy in breast cancer stem cells.
|Onjisaponin B isa natural product extracted from Polygonum. In PC-12 cells, Onjisaponin B can promote autophagy and accelerate the degradation of mutant α -synuclein and Huntington protein, which can be used to study Parkinson's disease and Huntington's disease.
|Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.
|Wogonoside is a flavonoid glycoside isolated from Scutellaria baicalensis and has anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating the MAPK-MTOR pathway.
|Daurisoline is an hERG inhibitor and also an autophagy inhibitor.
|Typhaneoside, extracted from Typha Angustifolia L., inhibits autophagy in hypoxia/reoxygenation cells and increases the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering lipid levels, promoting anti-atherosclerotic activity, and improving immune and clotting function.
|Syringin is one of the main bioactive phenolic glycosides in Acanthopanax senticosus and has anti-osteoporosis effect. Syringin prevents cardiac hypertrophy caused by pressure overload by inhibiting autophagy.
|Cyclovirobuxin D; CVB-D
|Cyclovirobuxine D (CVB-D) is the main active ingredient of Buxus microphylla. Cyclovirobuxine D induces autophagy and reduces Akt and mTOR phosphorylation. Cyclovirobuxine D inhibits the proliferation of cancer cells by inhibiting cell cycle progression and inducing mitochondria - mediated apoptosis. Cyclovirobuxine D has the potential to be used in the study of heart failure caused by myocardial infarction.
|Diosgenin-glucoside is a saponin compound extracted from Tritulus terrestris L., protects against spinal cord injury by regulating autophagy and alleviating apoptosis.
|Lycopene, a carotenoid naturally occurring in tomatoes, other red fruits and vegetables, promotes autophagy by activating the PI3K-Akt signaling pathway, thereby slowing down AAI-induced renal fibrosis. It also possesses antioxidant, anti-inflammatory, antimicrobial and anti-aging activities that
|Euphorbia Factor L1, a diterpenoid compound, can reduce the protein and mRNA levels of Bcl-2, PI3K, AKT and mTOR, and up-regulate the protein levels of Caspase-9 and Caspase-3. There was no effect on caspase-9 and caspase-3 protease. Euphorbia Factor L1 can induce autophagy and has anti-cancer, anti-adipogenesis, anti-osteoclast formation and multiple drug resistance regulation effects.
|Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.
|Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
|Acadesine; AICA Riboside
|AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy.
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