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 About 30 results found for searched term "Autophagy" (0.011 seconds)

Cat.No.  Name Information
M1759 GSK1120212 (Trametinib) Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis.
M1761 Vemurafenib (PLX4032) Vemurafenib (PLX4032) is the first and effective selective inhibitor of B-Raf, which can inhibit RAFV600E and C-RAF-1 activity with IC50 of 31 nM and 48 nM, respectively. Vemurafenib induces autophagy.
M1966 Fulvestrant Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect.
M1992 2-Methoxyestradiol 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa.
M10087 Ginkgolide K Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway.
M2238 Dorsomorphin (Compound C) dihydrochloride Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy.
M2294 Brefeldin A Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.
M2943 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
M3028 Spironolactone Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy.
M3244 Metformin Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro.
M3497 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
M3498 Nimodipine Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
M3539 Verteporfin (CL 318952) Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy.
M4084 Ginsenoside-F2 Ginsenoside F2, a metabolite of Ginsenoside Rb1, induces apoptosis and protective autophagy in breast cancer stem cells.
M4190 Onjisaponin-B Onjisaponin B isa natural product extracted from Polygonum. In PC-12 cells, Onjisaponin B can promote autophagy and accelerate the degradation of mutant α -synuclein and Huntington protein, which can be used to study Parkinson's disease and Huntington's disease.
M4361 Polyphyllin-I Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.
M4394 Wogonoside Wogonoside is a flavonoid glycoside isolated from Scutellaria baicalensis and has anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating the MAPK-MTOR pathway.
M4534 Daurisoline Daurisoline is an hERG inhibitor and also an autophagy inhibitor.
M4544 Typhaneoside Typhaneoside, extracted from Typha Angustifolia L., inhibits autophagy in hypoxia/reoxygenation cells and increases the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering lipid levels, promoting anti-atherosclerotic activity, and improving immune and clotting function.
M4579 Syringin Syringin is one of the main bioactive phenolic glycosides in Acanthopanax senticosus and has anti-osteoporosis effect. Syringin prevents cardiac hypertrophy caused by pressure overload by inhibiting autophagy.
M4580 Cyclovirobuxine Cyclovirobuxine D (CVB-D) is the main active ingredient of Buxus microphylla. Cyclovirobuxine D induces autophagy and reduces Akt and mTOR phosphorylation. Cyclovirobuxine D inhibits the proliferation of cancer cells by inhibiting cell cycle progression and inducing mitochondria - mediated apoptosis. Cyclovirobuxine D has the potential to be used in the study of heart failure caused by myocardial infarction.
M4704 Diosgenin-glucoside Diosgenin-glucoside is a saponin compound extracted from Tritulus terrestris L., protects against spinal cord injury by regulating autophagy and alleviating apoptosis.
M4787 Euphorbia-factor-L1 Euphorbia Factor L1, a diterpenoid compound, can reduce the protein and mRNA levels of Bcl-2, PI3K, AKT and mTOR, and up-regulate the protein levels of Caspase-9 and Caspase-3. There was no effect on caspase-9 and caspase-3 protease. Euphorbia Factor L1 can induce autophagy and has anti-cancer, anti-adipogenesis, anti-osteoclast formation and multiple drug resistance regulation effects.
M4838 TAK-242 (Resatorvid) Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.
M6097 Corynoxine Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
M5159 Hydroxychloroquine Sulfate Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
M5196 Spautin-1 Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.
M5409 Amiodarone Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
M5649 Flubendazole Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
M6086 SBI-0206965 SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .

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