About 31 results found for searched term "Autophagy" (0.059 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27718 | AUTEN-99 hydrobromide | Others |
| Autophagy enhancer-99 hydrobromide | ||
| AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 (hydrobromide) crosses the blood-brain barrier and exerts potent neuroprotective effects. | ||
| M1664 | AZD2281 (Olaparib) | PARP |
| Olaparib; KU-0059436 | ||
| AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively. Olaparib is an autophagy and mitophagy activator. | ||
| M1759 | GSK1120212 (Trametinib) | MEK |
| JTP-74057, GSK212 | ||
| Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis. | ||
| M1761 | Vemurafenib (PLX4032) | Raf |
| RG7204; RO5185426 | ||
| Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. | ||
| M1966 | Fulvestrant | Estrogen Receptor |
| ICI 182780; ZD 9238; ZM 182780 | ||
| Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. | ||
| M1992 | 2-Methoxyestradiol | HIF |
| 2ME2 | ||
| 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. | ||
| M2137 | Stavudine | Reverse Transcriptase |
| d4T | ||
| Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis. | ||
| M10087 | Ginkgolide K | Autophagy |
| Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. | ||
| M11303 | Glycodeoxycholic Acid | Metabolite/Endogenous Metabolite |
| Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. | ||
| M2238 | Dorsomorphin dihydrochloride | AMPK |
| BML-275 2HCl; Compound C 2HCl | ||
| Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. | ||
| M2276 | Torin 1 | mTOR |
| Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. Torin 1 induces cellular autophagy. | ||
| M2294 | Brefeldin A | ATPase |
| BFA; Cyanein; Decumbin | ||
| Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity. | ||
| M2558 | DMOG | HIF |
| Dimethyloxallyl Glycine | ||
| DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG induces cell autophagy. | ||
| M2575 | Dapivirine | Reverse Transcriptase |
| TMC120; R147681 | ||
| Dapivirine is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations. | ||
| M2626 | Dexamethasone Sodium Phosphate | Animal Modeling |
| Dexamethasone phosphate disodium | ||
| Dexamethasone Sodium Phosphate is a glucocorticoid receptor agonist that induces the production of lipocortin, a phospholipase A2 inhibitory protein. Dexamethasone inhibits autophagy levels in damaged cells in a dose-dependent manner. It can be used to construct models of allergic conjunctivitis. | ||
| M2943 | Pifithrin-μ | p53 |
| NSC 303580; PFTμ; 2-Phenylethynesulfonamide | ||
| Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. | ||
| M3026 | Sorafenib (BAY 43-9006) | Raf |
| BAY 43-9006 | ||
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib is a multikinase inhibitor with IC50 values of 15 nM, 20 nM, 57 nM and 58 nM for VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib is a ferroptosis activator. | ||
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M3244 | Metformin | AMPK |
| 1,1-Dimethylbiguanide | ||
| Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. | ||
| M3497 | Simvastatin (MK 733) | Autophagy |
| MK 733; MK-0733 | ||
| Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. | ||
| M3498 | Nimodipine | Calcium Channel |
| BAY-e 9736 | ||
| Nimodipine is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy. | ||
| M3499 | Ezetimibe | Autophagy |
| SCH 58235 | ||
| Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury. | ||
| M3539 | Verteporfin (CL 318952) | YAP |
| CL 318952; BPD-MA | ||
| Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy. | ||
| M4084 | Ginsenoside-F2 | Apoptosis |
| Ginsenoside F2, a metabolite of Ginsenoside Rb1, induces apoptosis and protective autophagy in breast cancer stem cells. | ||
| M4190 | Onjisaponin-B | Autophagy |
| Onjisaponin B isa natural product extracted from Polygonum. In PC-12 cells, Onjisaponin B can promote autophagy and accelerate the degradation of mutant α -synuclein and Huntington protein, which can be used to study Parkinson's disease and Huntington's disease. | ||
| M4227 | Liensinine | Autophagy |
| Liensinine is an autophagy/mitophagy inhibitor. | ||
| M4361 | Polyphyllin-I | JNK |
| Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. | ||
| M4394 | Wogonoside | Autophagy |
| Wogonoside is a flavonoid glycoside isolated from Scutellaria baicalensis and has anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating the MAPK-MTOR pathway. | ||
| M4498 | Hydroxysafflor-yellow-A | Autophagy |
| Safflomin A; HSYA | ||
| Hydroxysafflor-yellow-A (HSYA) is a water-soluble component of safflower, which has various pharmacological activities such as inhibiting platelet aggregation, anti-oxidation, and anti-inflammatory. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. | ||
| M4534 | Daurisoline | Autophagy |
| (R,R)-Daurisoline | ||
| Daurisoline is an hERG inhibitor and also an autophagy inhibitor. | ||
| M4544 | Typhaneoside | Autophagy |
| Typhaneoside, extracted from Typha Angustifolia L., inhibits autophagy in hypoxia/reoxygenation cells and increases the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering lipid levels, promoting anti-atherosclerotic activity, and improving immune and clotting function. | ||
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