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Dorsomorphin (Compound C) dihydrochloride

Cat. No. M2238
Dorsomorphin (Compound C) dihydrochloride Structure
Synonym:

BML-275 2HCl; Compound C 2HCl

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 54  USD54 In stock
5mg USD 49  USD49 In stock
10mg USD 69  USD69 In stock
25mg USD 147  USD147 In stock
50mg USD 267  USD267 In stock
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Quality Control & Documentation
Biological Activity

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling. Dorsomorphin dihydrochloride inhibits AMPK activation induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Dorsomorphin dihydrochloride induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. Dorsomorphin dihydrochloride induces autophagy.

Product Citations
Customer Product Validations & Biological Datas
Source Hum Mol Genet (2016). Figure 2. Dorsomorphin dihydrochloride
Method RT-qPCR
Cell Lines iPSC lines
Concentrations 1 μM
Incubation Time 72 h
Results We generated cortical neurons using a well-established protocol with small molecule dual SMAD inhibition for neural induction followed by plating of neuroepithelial cells for final differentiation
Protocol (for reference only)
Cell Experiment
Cell lines Spermatogonial Cell
Preparation method Dorsomorphin was added to the medium at a final concentration of 0, 1, 2, 4, or 8 µM (in final 0.4% dimethyl sulfoxide). The cells were maintained at 28.5°C in an atmosphere of 3% carbon dioxide and the medium was replaced every 3–4 days.
Concentrations 0, 1, 2, 4, or 8 µM
Incubation time 3 weeks
Animal Experiment
Animal models C57BL/6 mice
Formulation DMSO
Dosages 10 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 472.41
Formula C24H25N5O.2HCl
CAS Number 1219168-18-9
Solubility (25°C) Water 45 mg/mL
DMSO 5 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wong TT, et al. PLoS One. Dorsomorphin promotes survival and germline competence of zebrafish spermatogonial stem cells in culture.

[2] Hyeon Ung Park, et al. Mol Cancer Ther. AMP-activated protein kinase promotes human prostate cancer cell growth and survival

[3] Yu PB, et al. Nat Chem Biol. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

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Keywords: Dorsomorphin (Compound C) dihydrochloride, BML-275 2HCl; Compound C 2HCl supplier, AMPK, inhibitors, activators


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