Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling. Dorsomorphin dihydrochloride inhibits AMPK activation induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Dorsomorphin dihydrochloride induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
Indian J Pharm Sci. 2022;2022:84(3)284-293.
Gallic acid Inhibits M1 Macrophage Polarization via Adenosine 5'-Monophosphate-Activated Protein Kinase/Signal Transducers and Activators of
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Acta Histochem. 2022 Aug;124(6):151931.
Fibroblast-derived exosomal miRNA-133 promotes cardiomyocyte-like differentiation
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
J Food Biochem. 2022 Aug 5;e14351.
Liquiritin inhibits H2O2-induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Int J Mol Sci. 2023 Jan 5;24(2):1070.
Sulforaphane Suppresses H2O2-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Adv Sci (Weinh) . 2022 Nov 22;10(1):e2204463.
Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive-Like Disorders by Promoting ATP Production
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Int J Biol Sci. 2022 Jan 31;18(4):1594-1611.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Front Pharmacol. 2021 May 17;12:589273.
Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Front Oncol. 2021 Jan 29;10:614067.
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
BMC Cancer. 2021 Feb 25;21(1):195.
Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
J Cell Physiol. 2021 Mar;236(3):1889-1902.
Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Cell Physiol Biochem. 2018;50(6):2341-2364.
Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer.
Dorsomorphin (Compound C) dihydrochloride purchased from AbMole
Cell Experiment | |
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Cell lines | Spermatogonial Cell |
Preparation method | Dorsomorphin was added to the medium at a final concentration of 0, 1, 2, 4, or 8 µM (in final 0.4% dimethyl sulfoxide). The cells were maintained at 28.5°C in an atmosphere of 3% carbon dioxide and the medium was replaced every 3–4 days. |
Concentrations | 0, 1, 2, 4, or 8 µM |
Incubation time | 3 weeks |
Animal Experiment | |
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Animal models | C57BL/6 mice |
Formulation | DMSO |
Dosages | 10 mg/kg |
Administration | i.p. |
Molecular Weight | 472.41 |
Formula | C24H25N5O.2HCl |
CAS Number | 1219168-18-9 |
Solubility (25°C) | Water 45 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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