All AbMole products are for research use only, cannot be used for human consumption.
Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling. Dorsomorphin dihydrochloride inhibits AMPK activation induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Dorsomorphin dihydrochloride induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. Dorsomorphin dihydrochloride induces autophagy.
Biomed Pharmacother. 2024 May 23;176:116760.
Identification of a novel hypoglycemic small molecule, trans-2, 4-dimethoxystilbene by rectifying gut microbiota and activating hepatic AMPKα-PPARγ pathway through gut-liver axis
Dorsomorphin dihydrochloride purchased from AbMole
Int J Mol Sci. 2023 Jan 5;24(2):1070.
Sulforaphane Suppresses H2O2-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells
Dorsomorphin dihydrochloride purchased from AbMole
PLoS One. 2023 Dec 1;18(12):e0294566.
Silencing of topical proline hydroxylase domain 2 promotes the healing of rat diabetic wounds by phosphorylating AMPK
Dorsomorphin dihydrochloride purchased from AbMole
J Appl Toxicol. 2023 Feb 27.
AMP‐activated protein kinase‐farnesoid X receptor pathway contributes to oleanolic acid‐induced liver injury
Dorsomorphin dihydrochloride purchased from AbMole
Italian Journal of Food Science. 2023 Apr 17;35 (2): 13–21.
Pretreatment of kaempferol-3-O-rutinoside protects H9c2 cells against LPS-induced inflammation through the AMPK/SIRT1 pathway
Dorsomorphin dihydrochloride purchased from AbMole
Adv Sci (Weinh). 2022 Nov 22;10(1):e2204463.
Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates Depressive-Like Disorders by Promoting ATP Production
Dorsomorphin dihydrochloride purchased from AbMole
Int J Biol Sci. 2022 Jan 31;18(4):1594-1611.
Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway
Dorsomorphin dihydrochloride purchased from AbMole
J Food Biochem. 2022 Aug 5;e14351.
Liquiritin inhibits H2O2-induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway
Dorsomorphin dihydrochloride purchased from AbMole
Acta Histochem. 2022 Aug;124(6):151931.
Fibroblast-derived exosomal miRNA-133 promotes cardiomyocyte-like differentiation
Dorsomorphin dihydrochloride purchased from AbMole
Indian J Pharm Sci. 2022;2022:84(3)284-293.
Gallic acid Inhibits M1 Macrophage Polarization via Adenosine 5'-Monophosphate-Activated Protein Kinase/Signal Transducers and Activators of
Dorsomorphin dihydrochloride purchased from AbMole
Front Pharmacol. 2021 May 17;12:589273.
Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
Dorsomorphin dihydrochloride purchased from AbMole
J Cell Physiol. 2021 Mar;236(3):1889-1902.
Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway
Dorsomorphin dihydrochloride purchased from AbMole
Front Oncol. 2021 Jan 29;10:614067.
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis
Dorsomorphin dihydrochloride purchased from AbMole
BMC Cancer. 2021 Feb 25;21(1):195.
Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study
Dorsomorphin dihydrochloride purchased from AbMole
Cell Physiol Biochem. 2018;50(6):2341-2364.
Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer.
Dorsomorphin dihydrochloride purchased from AbMole
Cell Experiment | |
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Cell lines | Spermatogonial Cell |
Preparation method | Dorsomorphin was added to the medium at a final concentration of 0, 1, 2, 4, or 8 µM (in final 0.4% dimethyl sulfoxide). The cells were maintained at 28.5°C in an atmosphere of 3% carbon dioxide and the medium was replaced every 3–4 days. |
Concentrations | 0, 1, 2, 4, or 8 µM |
Incubation time | 3 weeks |
Animal Experiment | |
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Animal models | C57BL/6 mice |
Formulation | DMSO |
Dosages | 10 mg/kg |
Administration | i.p. |
Molecular Weight | 472.41 |
Formula | C24H25N5O.2HCl |
CAS Number | 1219168-18-9 |
Solubility (25°C) | Water 45 mg/mL DMSO 5 mg/mL (Need ultrasonic) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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