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AMPK activator 12

Cat. No. M41636
AMPK activator 12 Structure
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Biological Activity

AMPK activator 12 is a potent AMPK activator and GDF15 inducer.

Chemical Information
Molecular Weight 426.35
Formula C23H24BrNO2
CAS Number 431920-24-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sergey V Popov et al. Apoptosis. Regulation of autophagy of the heart in ischemia and reperfusion

[2] Canzhen Liu et al. Theranostics. A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells

[3] Wenxian Wu et al. Autophagy. TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy

[4] Mathieu Paquette et al. Autophagy. AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

[5] Irene Benito-Cuesta et al. Autophagy. AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

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Keywords: AMPK activator 12 supplier, AMPK, inhibitors, activators

 
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