About 33 results found for searched term "AMPK" (0.077 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13807 | Ampkinone | AMPK |
| Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator. | ||
| M41636 | AMPK activator 12 | AMPK |
| AMPK activator 12 is a potent AMPK activator and GDF15 inducer. | ||
| M41637 | CB1R/AMPK modulator 1 | Cannabinoid |
| CB1R/AMPK modulator 1 is an orally active CB1R/AMPK modulator, with an Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. | ||
| M1712 | FTY720 hydrochloride | S1P Receptor |
| Fingolimod hydrochloride | ||
| Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. | ||
| M1824 | SRT1720 Hydrochloride | Sirtuin |
| SRT-1720 Hydrochloride | ||
| SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. | ||
| M10087 | Ginkgolide K | Autophagy |
| Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. | ||
| M2238 | Dorsomorphin (Compound C) dihydrochloride | AMPK |
| BML-275 2HCl; Compound C 2HCl | ||
| Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. | ||
| M2647 | DMH1 | ALK |
| dorsomorphin homolog 1 | ||
| DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR. | ||
| M3244 | Metformin | AMPK |
| 1,1-Dimethylbiguanide | ||
| Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. | ||
| M3444 | A-769662 | AMPK |
| A-769662 is a potent, reversible AMPK activator with EC50of 0.8 μM, little effect on GPPase/FBPase activity. | ||
| M3899 | Salidroside | mTOR |
| Rhodioloside | ||
| Salidroside is a phenylpropanoid extracted from Rhodiola rosea that exhibits a protective effect against iron death by activating AMPK. It is also a prolyl endopeptidase inhibitor. | ||
| M3946 | BML-275 | AMPK |
| Dorsomorphin, Compound C | ||
| BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. | ||
| M4228 | Neferine | NF-κB |
| (-)-Neferine | ||
| Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M4256 | Gomisin-J | AMPK |
| Gomisin J isa small molecular weight lignan found in Schisandra chinensis with vasodilatory activity. Gomisin J regulates lipogenesis, lipolytic enzyme and inflammatory molecule expression to inhibit lipid accumulation by activating AMPK, LKB1 and Ca2+/ Calmodulin-dependent protein kinase II and inhibiting Fetuin-A in HepG2 cells. Gomisin J has potential benefits in the study of non-alcoholic fatty liver disease. | ||
| M4407 | Demethyleneberberine | NF-κB |
| Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD). | ||
| M4449 | Cimigenol-3-O-α-L-arabinoside | AMPK |
| Cimicifugoside M | ||
| Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential. | ||
| M4469 | Cinnamaldehyde | PPAR |
| Cinnamaldehyde is a naturally occurring flavonoid found in the bark of Cinnamomum cinnamomi and other Cinnamomum species such as camphor and cinnamon, and can act through a variety of signaling pathways, including PPARs, AMPK, PI3K/IRS-1, RBP4-GLUT4, ERK/JNK/p38MAPK, TRPA1-ghrelin, and the Nrf2 pathways.Cinnamaldehyde also has the potential to modulate the activities of PTP1B and α-amylase with antifungal activity and antioxidant activity. | ||
| M4483 | Platycodin-D | AMPK |
| Platycodin D, a saponin isolated from orange stem, is an activator of AMPKα and has anti-obesity activity. | ||
| M4575 | Vaccarin | AMPK |
| Vaccarin is an active flavonoid glycoside with a variety of biological functions. Vaccarin significantly promoted wound healing and proliferation of endothelial and fibroblast cells at the wound site. Vaccarin improves insulin resistance and steatosis by activating the AMPK signaling pathway. | ||
| M4897 | AICAR | AMPK |
| Acadesine; AICA Riboside | ||
| AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy. | ||
| M5019 | TCS-PIM-1-4a | Pim |
| SMI-4a | ||
| TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK; kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM). | ||
| M5207 | Bempedoic acid (ETC-1002) | AMPK |
| ESP-55016; Bempedoic acid | ||
| Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. | ||
| M5336 | Phenformin HCl | AMPK |
| Phenethylbiguanide hydrochloride | ||
| Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation. | ||
| M5549 | Danthron | AMPK |
| Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone | ||
| Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes. | ||
| M7173 | PT 1 | Others |
| PT 1 is a aMPK activator. | ||
| M8095 | PF-06409577 | AMPK |
| PF-6409577 | ||
| Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM. | ||
| M8761 | GSK621 | AMPK |
| GSK621 is a specific and potent AMPK activator with an IC50 value of 13-30 μM for AML cell lines. GSK621 can induce autophagy and apoptosis. | ||
| M9764 | MK-3903 | AMPK |
| MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). | ||
| M9911 | IM156 | AMPK |
| HL156A | ||
| IM156, a metformin derivative, is an oxidative phosphorylation inhibitor that increases AMPK phosphorylation. | ||
| M10620 | Kudinoside D | Others |
| Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes. | ||
| M10948 | MOTS-c(Human) Acetate | AMPK |
| MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. | ||
| M11007 | O-304 | AMPK |
| O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK. | ||
| M11324 | BC1618 | AMPK |
| BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver. | ||
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