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PF-06409577

Cat. No. M8095
PF-06409577 Structure
Synonym:

PF-6409577

Size Price Availability Quantity
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
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Quality Control
Biological Activity

PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 341.79
Formula C19H16ClNO3
CAS Number 1467057-23-3
Purity 99.25%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

[1] Christopher T Salatto, et al. J Pharmacol Exp Ther. Selective Activation of AMPK β 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PF-06409577, PF-6409577 supplier, AMPK, inhibitors

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