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Humanized monoclonal antibody (mAb)

Cat.No.  Name Information
M6224 Etanercept Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive.
M6223 Tocilizumab Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.
M6221 Pertuzumab Pertuzumab, a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors, impairs the ability of HER2 to bind to other members of the HER family, MW: 148 KD.
M6218 Trastuzumab Trastuzumab is a humanized, recombinant monoclonal antibody that binds to the extracellular domain of HER2, MW:145.53 KD.
M6166 Bevacizumab Bevacizumab (anti-VEGF, Avastin) is a humanized anti-VEGF monoclonal antibody that is an inhibitor of VEGF. It binds to, and neutralizes, all human-derived VEGF-A isoforms (and biologically active protein hydrolysis fragments).MW:149 KD.
M6101 Atezolizumab Atezolizumab (atezolizumab) is a humanized anti-PD-L1 monoclonal antibody that inhibits PD-L1 signaling with PD-1 and B7-1 and restores tumor-specific T-cell immunity. However, it does not affect the interaction of PD-L2 with PD-1. MW: 145 KD. atezolizumab reacts with murine PD-L1 (for human and non-humanized mice).
M6100 Nivolumab Nivolumab (nabumab) is a fully humanized IgG4 monoclonal antibody against PD-1. It has immune checkpoint inhibitory activity and antitumor activity; MW: 143.597 KD.(for human-derived mice).
M3835 Alirocumab Alirocumab is a humanized IgG1 PCSK9 monoclonal antibody that can be used in the study of hypercholesterolemia.
M3813 Avelumab (MSB0010718C) Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). Avelumab recognizes murine PD-L1
M1503 Panitumumab Panitumumab is a fully human IgG2 monoclonal antibody specific to the epidermal growth factor receptor (EGFR).
M40939 Rat IgG2b Isotype Control In vivo Rat IgG2b Isotype Control In vivo monoclonal antibody (Clone:1-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications.
M40936 Anti-Mouse CD4 (Clone GK1.5) In vivo Anti-Mouse CD4 (Clone GK1.5) antibody recognizes an epitope on Mouse CD4.
M40935 Anti-Mouse IFNγ (interferon gamma) (Clone H22) In vivo Anti-Mouse IFNγ (interferon gamma) (Clone H22) antibody recognizes an epitope on Mouse IFN-γ. Interferon-gamma (IFN-γ) is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
M40934 Anti-Mouse CTLA-4 (Clone 9D9) In vivo Anti-Mouse CTLA-4 Antibody (Clone 9D9) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes.
M40918 Anti-Mouse Ly6G (Clone 1A8) In vivo Anti-Mouse Ly6G antibody (Clone 1A8) In vivo recognizes an epitope on mouse Ly6G. Ly6G is expressed by neutrophils.
M40909 Anti-Mouse CD8a (Clone 53-6.7) In vivo Anti-Mouse CD8a (Clone 53-6.7) In vivo recognizes Lyt 2. Clone 53-6.7 competes with clone 5H10-1 for binding to thymocytes.
M40856 Anti-Mouse CD4 (Clone YTS191) In vivo Anti-Mouse CD4 (Clone YTS191) recognizes an epitope on mouse CD4. CD4 is expressed on most thymocytes, MHC class II-restricted T cells, a subset of NKT cells, and subsets of dendritic cells and macrophages.
M40830 Anti-Mouse CD3ε In vivo Anti-Mouse CD3ε (Clone 145-2C11) recognizes an epitope on mouse CD3ε. CD3ε is primarily expressed on mature T cells and NK-T cells and at different levels on differentiation-dependent thymocytes.
M40828 Anti-Mouse CTLA-4 (Clone 9H10) In vivo Anti-Mouse CTLA-4 (Clone 9H10) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes.
M40812 Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo has been used to identify peripheral blood neutrophils and deplete granulocytes in vivo.

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