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Cat. No. M6224
Etanercept Structure
Size Price Availability Quantity
2mg USD 580  USD580 In stock
5mg USD 780  USD780 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Etanercept conjugated with IRDye800CW exhibited a D/P ratio of 2.5:1. The measured concentration of the I-E conjugates was 1.01 mg/ml, which is close to the etanercept concentration (1 mg/ml) used in the labeling reaction. This suggests that there was no loss of etanercept during the reaction and purification process.

Product Citations
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models CIA rats
Dosages 5 mg/kg
Administration s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 51234.33
Formula C2224H3475N621O698S36
CAS Number 185243-69-0
Purity >98%
Storage -80°C for long term

[1] Chen X, et al. Drug Metab Dispos. Biodistribution of Etanercept to Tissues and Sites of Inflammation in Arthritic Rats

[2] Murdaca G, et al. Expert Opin Drug Saf. Efficacy and safety of etanercept in chronic immune-mediated disease.

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Keywords: Etanercept supplier, TNF-alpha, inhibitors

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