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Etanercept

Cat. No. M6224
Etanercept Structure
Size Price Availability Quantity
2mg USD 580  USD580 In stock
5mg USD 780  USD780 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive.

Product Citations
Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models CIA rats
Formulation
Dosages 5 mg/kg
Administration s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 51234.33
Formula C2224H3475N621O698S36
CAS Number 185243-69-0
Purity >98%
Solubility
Storage -80°C for long term
References

[1] Hong Xue, et al. Int J Chron Obstruct Pulmon Dis . Etanercept Protected Against Cigarette Smoke Extract-Induced Inflammation and Apoptosis of Human Pulmonary Artery Endothelial Cells via Regulating TNFR1

[2] Ya Li, et al. Molecules . M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction

[3] Chen X, et al. Drug Metab Dispos. Biodistribution of Etanercept to Tissues and Sites of Inflammation in Arthritic Rats

[4] Murdaca G, et al. Expert Opin Drug Saf. Efficacy and safety of etanercept in chronic immune-mediated disease.

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Keywords: Etanercept supplier, TNF-alpha, inhibitors

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