| Cat.No. | Name | Information |
|---|---|---|
| M58114 | Ceramides | Ceramides, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides is a main lipid component of the permeability barrier in epidermis. |
| M58111 | Lauroyl-L-carnitine chloride | Lauroyl-L-carnitine chloride can be used as an absorption enhancer. |
| M58110 | Recombinant Human RIPK3 Protein (E. coli, N-His) | RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury. |
| M58109 | MMP-9 Inhibitor I | MMP-9 inhibitor I is a cell-permeable, potent, selective, and reversible inhibitor of MMP-9 (IC50 = 5 nM). MMP-9 inhibitor I also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. |
| M58108 | SI-2 hydrochloride | SI-2 hydrochloride is a highly promising SRC-3 inhibitor (PPI) with acceptable oral availability, with IC50 values of 3-20 nM for breast cancer cell death. |
| M58107 | PD-1/PD-L1-IN-9 | PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model. |
| M58106 | NCT-505 | NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM. NCT-505 weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57, 22.8, 20.1, >57 μM, respectively. |
| M58105 | Lysozyme | Lysozyme (EC 3.2.1.17) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. |
| M58104 | Nicotinic acid mononucleotide triethylamine | Nicotinic acid mononucleotide triethylamine is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide triethylamine is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase. |
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