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M10475 Lifirafenib (BGB-283) Lifirafenib (BGB-283) is a novel potent and selective RAF Kinase and EGFR inhibitor with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
M10474 Delgocitinib (JTE-052) Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor with IC50 values of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
M10473 MK-3118 MK-3118 is a novel glucan synthase inhibitor with activity against many echinocandin-resistant strains of Candida due to differential avidity for the target site compared to echinocandins.
M10472 AZD3759 hydrochloride AZD3759 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) with potential antineoplastic activity.
M10471 MTI-31 (LXI-15029) MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays.
M10470 Raxatrigine hydrochloride Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker.
M10469 MCH TFA (human, mouse, rat) MCH TFA (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively.
M10468 N-Formyl-Met-Leu-Phe N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion.




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