Cat.No. | Name | Information |
---|---|---|
M13394 | HDM201 (Siremadlin) | HDM201 (Siremadlin) is a novel, highly effective and selective inhibitor of P53-MDM2 interaction. |
M13393 | NVP-CGM097 | NVP-CGM097 is a highly effective and selective MDM2 inhibitor with a Ki value of 1.3 nM. |
M13392 | GeA-69 | GeA-69 is a cell-penetrating selective allosteric inhibitor targeting Macrodomain 2 (MD2) with a Kd of 2.1 µM. |
M13391 | RBN012759 | RBN012759 is a potent, selective and orally active PARP14 inhibitor with IC50 values of <3 nM and 5 nM against the human and mouse catalytic domains, respectively. AIDS in the anti-tumor immune response. |
M13390 | C527 | C527 is an inhibitor of pan-dub enzyme with an IC50 value of 0.88 μM. |
M13389 | ACBI1 | ACBI1 is an effective and synergistic PROTAC inhibitor of SMARCA2, SMARCA4 and PBRM1, with DC50 of 6 nM, 11 nM and 32 nM in MV-4-11 cells, respectively. ACBI1 can induce antiproliferative effect and apoptosis. |
M13388 | RP-6306 | RP-6306 is the only inhibitor of PKMYT1 currently available in the clinic, which is synthetically fatal to CCNE1 amplification, FBXW7 deletion or other specific mutations. |
M13387 | SNDX-5613 | SNDX-5613 is an effective and selective Menin-MLL binding inhibitor with Ki of 0.15 nM. Sndx-5613 can be used to study MLL gene rearrangement in acute leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). |
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