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GlcNAcstatin

Cat. No. M2723
GlcNAcstatin Structure
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5mg USD 300  USD300 Out of stock
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Biological Activity

GlcNAcstatin is a selective O-GlcNAcase (OGA) inhibitor with Ki of 4.6 pM.

Product Citations
Chemical Information
Molecular Weight 373.45
Formula C20H27N3O4
CAS Number 922163-64-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Helge C Dorfmueller, et al. Biochem J. GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

[2] Helge C Dorfmueller, et al. J Am Chem Soc. GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

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Keywords: GlcNAcstatin supplier, OGA/OGT, inhibitors, activators


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