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Thiamet G

Cat. No. M3064

All AbMole products are for research use only, cannot be used for human consumption.

Thiamet G  Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Healthy Sprague-Dawley rats
Formulation Drinking water (p.o.)
Dosages 200 mg/kg (p.o.), ~50 mg/kg (i.v.)
Administration Administrated by p.o. or i.v.
Chemical Information
Molecular Weight 248.3
Formula C9H16N2O4S
CAS Number 1009816-48-1
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Maria Cecilia Oliveira-Nunes, et al. O-GlcNAcylation protein disruption by Thiamet G promotes changes on the GBM U87-MG cells secretome molecular signature

[2] Tomoharu Takeuchi, et al. Osteoclast Differentiation Is Suppressed by Increased O-GlcNAcylation Due to Thiamet G Treatment

[3] Hye-Yeon Kim, et al. O-GlcNAcylation of light chain serine 12 mediates rituximab production doubled by thiamet G

[4] Hongsheng Liang, et al. Upregulated protein O-GlcNAcylation promoted functional and structural recovery of the contused spinal cord injury in rats by Thiamet-G treatment

[5] Ning Ding, et al. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel

Related OGA/OGT Products
GlcNAcstatin

GlcNAcstatin is a selective O-GlcNAcase (OGA) inhibitor with Ki of 4.6 pM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Thiamet G supplier, OGA/OGT, inhibitors, activators

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