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Tribromoethyl alcohol

Cat. No. M14641
Tribromoethyl alcohol Structure
Synonym:

2,2,2-Tribromoethanol; Narcolan

Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Tribromoethyl alcohol (2,2,2-Tribromoethanol) is used to animals, particularly rodents, before surgery.

Product Citations
Chemical Information
Molecular Weight 282.76
Formula C2H3Br3O
CAS Number 75-80-9
Solubility (25°C) Ethanol ≥ 200 mg/mL
DMSO ≥ 30 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Derek M Denning, et al. Solvent-dependent photochemistry of 2,2,2-tribromoethyl-(2'-phenylacetate)

[2] N S SOFRONOV. [Effect of narcolan (tribromoethyl alcohol) on the higher nervous function in dogs]

[3] J J Hans, et al. Direct transacylation of 2,2,2-trihaloethyl esters with amines and alcohols using phosphorus (III) reagents for reductive fragmentation and in situ activation

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Keywords: Tribromoethyl alcohol, 2,2,2-Tribromoethanol; Narcolan supplier, Animal experimental anesthetics, inhibitors, activators


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