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MS-222

Cat. No. M14788
MS-222 Structure
Synonym:

Tricaine methanesulfonate; TMS

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Quality Control & Documentation
Biological Activity

Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures.

Product Citations
Chemical Information
Molecular Weight 261.29
CAS Number 886-86-2
Solubility (25°C) Water 150 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sheryl Bradley, et al. USE OF TRICAINE METHANESULFONATE, CLOVE OIL AND 2-PHENOXYETHANOL FOR IMMERSION EUTHANASIA OF UNGA CICHLIDS ( SAROTHERODON LINELLII)

[2] Barbara D Fontana, et al. Tricaine Methanesulfonate (MS222) Has Short-Term Effects on Young Adult Zebrafish ( Danio rerio) Working Memory and Cognitive Flexibility, but Not on Aging Fish

[3] No authors listed. Erratum: A Comparison of Buffered Tricaine Methanesulfonate (MS-222) and Isoeugenol Anesthesia for Caudal Fin Clipping in Zebrafish ( Danio rerio)

[4] Gabrielle C Musk, et al. A Comparison of Buffered Tricaine Methanesulfonate (MS-222) and Isoeugenol Anesthesia for Caudal Fin Clipping in Zebrafish ( Danio rerio)

[5] Erin M Katz, et al. The Stability and Efficacy of Tricaine Methanesulfonate (MS222) Solution After Long-Term Storage

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Keywords: MS-222, Tricaine methanesulfonate; TMS supplier, Animal experimental anesthetics, inhibitors, activators


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