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Tolycaine is an amide local anaesthetic. Tolycaine induces convulsions by modification of monoamines in rat brain. Tolycaine significantly inhibited Na+-dependent active uptake of methyl alpha-D-glucoside and L-leucine while leaving uptake of D-fructose (facilitated diffusion) and 2-deoxy-D-glucose (passive diffusion) unaffected.
Tolycaine exhibits good anesthetic effects on mice. Tolycaine (140 mg/kg, intraperitoneally) produced a significant elevation of noradrenaline and 5-hydroxytryptamine levels in all brain regions in the convulsive state from the levels in the non-convulsive state. Their levels returned to normal during the postconvulsive state.
| Molecular Weight | 278.35 |
| Formula | C15H22N2O3 |
| CAS Number | 3686-58-6 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Animal experimental anesthetics Products |
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