Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits mouse heart MAO (type B) and rat heart MAO (type A) with IC50 of 62 μM and 400 μM, respectively.
| Molecular Weight | 306.44 |
| Formula | C18H30N2O2 |
| CAS Number | 149-16-6 |
| Solubility (25°C) | DMSO 60 mg/mL (ultrasonic and warming) |
| Storage | 4°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Animal experimental anesthetics Products |
|---|
| Orthocaine
Orthocaine is a local anesthetic agent. |
| Tolycaine
Tolycaine is an amide local anaesthetic. Tolycaine exhibits good anesthetic effects on mice. |
| Etidocaine hydrochloride
Etidocaine hydrochloride is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties. |
| Lidocaine N-ethyl bromide
Lidocaine N-ethyl bromide is a blocker of non-membrane-permeable,and Inhibits Acid-Induced Activation of Esophageal Nociceptive C Fiber Neurons. |
| MS-222
Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
