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Etidocaine hydrochloride

Cat. No. M25452
Etidocaine hydrochloride Structure
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1mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Etidocaine hydrochloride is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties.

Chemical Information
Molecular Weight 312.88
Formula C17H29ClN2O
CAS Number 36637-19-1
Solubility (25°C) DMSO
Methanol
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] O T Jensen, et al. J Oral Surg. Advantages of long-acting local anesthesia using etidocaine hydrochloride

[2] A L Sisk, et al. J Oral Maxillofac Surg. Evaluation of etidocaine hydrochloride for local anesthesia and postoperative pain control in oral surgery

[3] A L Sisk. J Oral Maxillofac Surg. Comparison of etidocaine and lidocaine for control of intra- and post-operative bleeding and pain

[4] S A Lytle, et al. J Am Osteopath Assoc. Combining epidural fentanyl and lidocaine for postoperative pain

[5] T M Murphy, et al. Br J Anaesth. The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia I: block characteristics and cardiovascular effects

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