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Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones. Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.
Hum ExpToxicol. 2022 Jan-Dec;41:9603271221124096.
Valtrate antagonizes malignant phenotypes of lung cancer cells by reducing SLC7A11
Valepotriate purchased from AbMole
| Molecular Weight | 422.47 |
| Formula | C22H30O8 |
| CAS Number | 18296-44-1 |
| Form | Oil |
| Solubility (25°C) | DMSO ethanol |
| Storage | -20°C, protect from light, sealed |
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