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Valepotriate

Cat. No. M10566
Valepotriate Structure
Synonym:

Valtrate

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones. Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

Product Citations
Chemical Information
Molecular Weight 422.47
Formula C22H30O8
CAS Number 18296-44-1
Form Oil
Solubility (25°C) DMSO
ethanol
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] You-You Yan, et al. Acta Pharmacol Sin. A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

[2] Liz G Mller, et al. Behav Pharmacol. A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice

[3] No authors listed. Valerian

[4] An Wu, et al. Pharmacogn Mag. Anti-epileptic Effects of Valepotriate Isolated from Valeriana jatamansi Jones and Its Possible Mechanisms

[5] Sheng Lin, et al. J Asian Nat Prod Res. Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity

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Keywords: Valepotriate, Valtrate supplier, Apoptosis, inhibitors, activators


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