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Valepotriate (Valtrate)

Cat. No. M10566
Valepotriate (Valtrate) Structure
Synonym:

Valtrate

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 330  USD330 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones. Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 422.47
Formula C22H30O8
CAS Number 18296-44-1
Purity >98%
Solubility DMSO
ethanol
Storage -20°C, protect from light, sealed
References

[1] You-You Yan, et al. Acta Pharmacol Sin. A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells

[2] Liz G Mller, et al. Behav Pharmacol. A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice

[3] No authors listed. Valerian

[4] An Wu, et al. Pharmacogn Mag. Anti-epileptic Effects of Valepotriate Isolated from Valeriana jatamansi Jones and Its Possible Mechanisms

[5] Sheng Lin, et al. J Asian Nat Prod Res. Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity

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Keywords: Valepotriate (Valtrate), Valtrate supplier, inhibitors

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