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Apoptosis Apoptosis related

Inhibitors

Cat.No.  Name Information
M11450 Chaetoglobosin A Chaetoglobosin A is an active ingredient in the extract of Penicillium aquamarinium and A member of cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells, thereby inducing cell cycle arrest and inhibiting membrane folds and cell migration.
M11368 STM2457 STM2457 is a pioneering, highly effective, selective, orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used in the study of acute leukemia.
M11366 Se-Methylselenocysteine Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis.
M11342 LCS-1 LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S).
M11334 Levomenol Levomenol ((-)-α -bisabolol) isa monocyclic sesquiterpenoid alcohol with antioxidant, anti-inflammatory and anti-apoptotic effects. Levomenol also has neuroprotective effects, preventing neuronal damage and memory deficits by reducing pro-inflammatory markers of permanent focal cerebral ischemia induction in mice. Levomenol reduces nociceptive behavior and central sensitivity in a rodent model of trigeminal pain.
M11210 MN58b MN58b is a selective inhibitor of choline kinase α (CHKα) and inhibits phosphocholine synthesis. MN58b induces apoptosis to reduce cell growth. MN58b also has antitumoral activity.
M11195 CDDO-2-P-Im Cddo-2p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-2p-im reduced the size and severity of lung tumors in mouse lung cancer models. Cddo-2p-im is an orally active necroptosis inhibitor that can be used in ischemia/reperfusion (I/R) studies.
M11194 CDDO-3-P-Im Cddo-3p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-3p-im can reduce the size and severity of lung tumors in mouse lung cancer models.
M11178 Taurochenodeoxycholic acid Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animal bile acids. Taurochenodeoxycholic acid induces apoptosis (apoptosis) and has a pronounced anti-inflammatory and immunomodulatory effect.
M11170 NSC745885 NSC745885 is a potent anti-tumor reagent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent downregulator of EZH2 through the proteasome degradation pathway. NSC745885 offers the possibility of research on advanced bladder cancer and oral squamous cell carcinoma.
M11093 Ranaconitine Ranaconitine is a diterpene alkaloid isolated from A. leucostomum and is cardiotoxic.
M11048 Isolongifolene Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene mitigates rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathway.
M11040 AMXT-1501 tetrahydrochloride AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT-1501 blocks tumor growth in immunocompetent mice, but not T cell-deficient thymic nude mice. DFMO and AMXT-1501 jointly induce caspase-3-mediated apoptosis of NB cells.
M11001 COG-1410 COG1410 is a peptide derived from apolipoprotein E. COG1410 plays a neuroprotective and anti-inflammatory role in a mouse brain injury (TBI) model. COG1410 can be used in the study of neurological diseases.
M10998 Soyasapogenol A Soyasapogenol A, a triterpenoid compound isolated from the roots of Abrus cantoniensis.
M10997 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC for COLO 205, HCT-116 and HT-29 cells) by inducing apoptosis (apoptosis) and autophagy50 9.0, 40.2 and 70.9 μM, respectively).
M10972 Coniferaldehyde Coniferaldehyde (Ferulaldehyde) is a potent inducer of heme oxygenase-1 (HO-1) with anti-inflammatory effects. In RAW264.7 macrophages, Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/βII/Nrf-2/HO-1-dependent pathway.
M10967 Coenzyme Q9 Coenzyme Q9 (Ubiquinone Q9), the main form of rodent ubiquinone, is a biparent molecular component in the electron transport chain that acts as an endogenous antioxidant. Coenzyme Q9 mitigates a decline in antioxidant defense mechanisms caused by diabetes. Coenzyme Q9 improves left ventricular function, reduces myocardial infarction area and apoptosis of myocardial cells.
M10757 Flavokawain B Flavokawain B (Flavokavain B) is a chalcone isolated from the root extract of kava drunken pepper and is an effective apoptotic inducer that inhibits the growth of various cancer cell lines. (Flavokavain B) has strong anti-angiogenic activity. (Flavokavain B) inhibits the migration and vascular formation of human brain endothelial cells (HUVEC) at very low non-toxic concentrations.
M10756 Flavokawain A Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research.



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