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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M11450 | Chaetoglobosin A | Chaetoglobosin A is an active ingredient in the extract of Penicillium aquamarinium and A member of cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells, thereby inducing cell cycle arrest and inhibiting membrane folds and cell migration. |
| M11368 | STM2457 | STM2457 is a pioneering, highly effective, selective, orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used in the study of acute leukemia. |
| M11366 | Se-Methylselenocysteine | Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis. |
| M11342 | LCS-1 | LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibited SOD1 activity with IC50 value of 1.07 μM. LCS-1 induces early and late apoptosis in multiple myeloma cells (MM.1S). |
| M11334 | Levomenol | Levomenol ((-)-α -bisabolol) isa monocyclic sesquiterpenoid alcohol with antioxidant, anti-inflammatory and anti-apoptotic effects. Levomenol also has neuroprotective effects, preventing neuronal damage and memory deficits by reducing pro-inflammatory markers of permanent focal cerebral ischemia induction in mice. Levomenol reduces nociceptive behavior and central sensitivity in a rodent model of trigeminal pain. |
| M11210 | MN58b | MN58b is a selective inhibitor of choline kinase α (CHKα) and inhibits phosphocholine synthesis. MN58b induces apoptosis to reduce cell growth. MN58b also has antitumoral activity. |
| M11195 | CDDO-2-P-Im | Cddo-2p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-2p-im reduced the size and severity of lung tumors in mouse lung cancer models. Cddo-2p-im is an orally active necroptosis inhibitor that can be used in ischemia/reperfusion (I/R) studies. |
| M11194 | CDDO-3-P-Im | Cddo-3p-im is a CDDO imidazolid analogue with chemoprophylaxis. Cddo-3p-im can reduce the size and severity of lung tumors in mouse lung cancer models. |
| M11178 | Taurochenodeoxycholic acid | Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animal bile acids. Taurochenodeoxycholic acid induces apoptosis (apoptosis) and has a pronounced anti-inflammatory and immunomodulatory effect. |
| M11170 | NSC745885 | NSC745885 is a potent anti-tumor reagent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent downregulator of EZH2 through the proteasome degradation pathway. NSC745885 offers the possibility of research on advanced bladder cancer and oral squamous cell carcinoma. |
| M11093 | Ranaconitine | Ranaconitine is a diterpene alkaloid isolated from A. leucostomum and is cardiotoxic. |
| M11048 | Isolongifolene | Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene mitigates rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathway. |
| M11040 | AMXT-1501 tetrahydrochloride | AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT-1501 blocks tumor growth in immunocompetent mice, but not T cell-deficient thymic nude mice. DFMO and AMXT-1501 jointly induce caspase-3-mediated apoptosis of NB cells. |
| M11001 | COG-1410 | COG1410 is a peptide derived from apolipoprotein E. COG1410 plays a neuroprotective and anti-inflammatory role in a mouse brain injury (TBI) model. COG1410 can be used in the study of neurological diseases. |
| M10998 | Soyasapogenol A | Soyasapogenol A, a triterpenoid compound isolated from the roots of Abrus cantoniensis. |
| M10997 | 3'-Hydroxypterostilbene | 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC for COLO 205, HCT-116 and HT-29 cells) by inducing apoptosis (apoptosis) and autophagy50 9.0, 40.2 and 70.9 μM, respectively). |
| M10972 | Coniferaldehyde | Coniferaldehyde (Ferulaldehyde) is a potent inducer of heme oxygenase-1 (HO-1) with anti-inflammatory effects. In RAW264.7 macrophages, Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/βII/Nrf-2/HO-1-dependent pathway. |
| M10967 | Coenzyme Q9 | Coenzyme Q9 (Ubiquinone Q9), the main form of rodent ubiquinone, is a biparent molecular component in the electron transport chain that acts as an endogenous antioxidant. Coenzyme Q9 mitigates a decline in antioxidant defense mechanisms caused by diabetes. Coenzyme Q9 improves left ventricular function, reduces myocardial infarction area and apoptosis of myocardial cells. |
| M10757 | Flavokawain B | Flavokawain B (Flavokavain B) is a chalcone isolated from the root extract of kava drunken pepper and is an effective apoptotic inducer that inhibits the growth of various cancer cell lines. (Flavokavain B) has strong anti-angiogenic activity. (Flavokavain B) inhibits the migration and vascular formation of human brain endothelial cells (HUVEC) at very low non-toxic concentrations. |
| M10756 | Flavokawain A | Flavokawain A is an anticarcinogenic agent, a chalcone found in kava extracts with antitumor activity. Flavokawain A induces apoptosis through Bax protein-dependent and mitochondrial-dependent apoptosis pathways. Flavokawain A has the potential to be used in bladder cancer related research. |
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