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CWI1-2

Cat. No. M40996
CWI1-2  Structure
Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 220  USD220 In stock
25mg USD 470  USD470 In stock
50mg USD 750  USD750 In stock
100mg USD 1180  USD1180 In stock
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Quality Control & Documentation
Biological Activity

CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and possesses anti-leukemic activity.

Chemical Information
Molecular Weight 519.77
Formula C22H17Cl3N6O3
CAS Number 2408590-36-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hengyou Weng et al. Cancer Cell. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

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Keywords: CWI1-2 supplier, Apoptosis, inhibitors, activators


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