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23-Hydroxybetulinic acid is a novel anticancer substance. 23-Hydroxybetulinic acid enhanced the cytotoxicity of ABCB1 substrates and increased the accumulation of doxorubicin or rhodamine123 in ABCB1 overexpressing cells, but had no effect on non ABCB1 substrate, such as cisplatin. In addition, 23-Hydroxybetulinic acid inhibited the verapamil-stimulated ABCB1 ATPase activity and the photolabeling of ABCB1 with [(125)I] iodoarylazidoprazosin in a concentration-dependent manner, indicating that 23-Hydroxybetulinic acid directly interacts with ABCB1. Importantly, 23-Hydroxybetulinic acid increased the inhibitory effect of paclitaxel in ABCB1 overexpressing KB-C2 cell xenografts in nude mice.
| Molecular Weight | 472.7 |
| Formula | C30H48O4 |
| CAS Number | 85999-40-2 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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