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Cat. No. M11366
Se-Methylselenocysteine Structure

Methylselenocysteine; Se-Methylseleno-L-cysteine

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 82  USD82 In stock
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Quality Control & Documentation
Biological Activity

Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis.

Chemical Information
Molecular Weight 182.08
Formula C4H9NO2Se
CAS Number 26046-90-2
Solubility (25°C) Water ≥ 60 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jin Wang, et al. J Food Sci. Sex-dimorphic distribution and anti-oxidative effects of selenomethionine and Se-methylselenocysteine supplementation

[2] Jun Ding, et al. Med Sci Monit. Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway

[3] Jia Ma, et al. Cell Prolif. L-Se-methylselenocysteine sensitizes lung carcinoma to chemotherapy

[4] Xiubo Du, et al. ACS Chem Neurosci. Se-Methylselenocysteine (SMC) Improves Cognitive Deficits by Attenuating Synaptic and Metabolic Abnormalities in Alzheimer's Mice Model: A Proteomic Study

[5] Dongsoo Kim, et al. J Trace Elem Med Biol. Se-methylselenocysteine stimulates migration and antioxidant response in HaCaT keratinocytes: Implications for wound healing

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Keywords: Se-Methylselenocysteine, Methylselenocysteine; Se-Methylseleno-L-cysteine supplier, Apoptosis, inhibitors, activators

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