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C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway.
C6 Ceramide signifcantly increased the expression of miR29b and decreased the expressions of Akt3, PI3K and VEGFA in HUVECs. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects.
| Molecular Weight | 397.63 |
| Formula | C24H47NO3 |
| CAS Number | 124753-97-5 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL Ethanol 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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