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 About 33 results found for searched term "Apoptosis" (0.039 seconds)

Cat.No.  Name Target
M2403 Apoptosis Activator 2 Caspase
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
M41299 Apoptosis inducer 12 Apoptosis
Apoptosis inducer 12 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway.
M41304 Apoptosis inducer 11 Apoptosis
Apoptosis inducer 11 induces apoptosis through the mitochondrial pathway.
M41362 Apoptosis inducer 13 ROS
Apoptosis inducer 13 can induce cancer cell apoptosis, and inhibits cancer cell migration and invasion.
M1759 GSK1120212 (Trametinib) MEK
JTP-74057, GSK212
Trametinib (GSK1120212; Jtp-74057) is an orally effective MEK inhibitor with IC50 of 2 nM against MEK1 and MEK2, respectively. Trametinib can activate autophagy and induce apoptosis.
M1940 Docetaxel Microtubule
Docetaxel (Taxotere), a semi-synthetic analog of paclitaxel (Taxol), is a promoter of microtubule polymerization leading to cell cycle arrest at G2/M, apoptosis and cytotoxicity.
M1966 Fulvestrant Estrogen Receptor
ICI 182780; ZD 9238; ZM 182780
Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect.
M1969 Doxorubicin HCL Animal Modeling
RP 13057 hydrochloride; Adriamycin; Rubex;DOX
Doxorubicin HCl (Adriamycin, DOX, RP 13057) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
M1992 2-Methoxyestradiol HIF
2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa.
M2026 AT-406 IAP
SM-406; Xevinapant; Debio 1143
Xevinapant (Debio1143,AT-406, SM-406) is a potentially first-in-class, highly potent oral antagonist of inhibitor of apoptosis protein (IAP), which not only promotes cancer cell death by inhibiting IAP, but also It can enhance the anti-tumor immune response by inhibiting IAP.
M2036 Pifithrin-α p53
Pifithrin hydrobromide; PFTα hydrobromide
Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.
M2068 JNJ-26854165 p53
JNJ-26854165 (Serdemetan) is a novel activator of p53 capable of inducing apoptosis in cancer cell lines.
M2083 Elesclomol Cuproptosis
Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion-carrier that can be used for cuproptosis studies.
M2138 GDC-0152 IAP
GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins with potential antineoplastic activity.
M2144 Topotecan hydrochloride Topoisomerase
Hycamtin, NSC 609669
Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M11366 Se-Methylselenocysteine Apoptosis
Methylselenocysteine; Se-Methylseleno-L-cysteine
Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis.
M2598 Inauhzin p53
Inauhzin is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
M2599 Methylisoindigotin Others
Natura-α, N-Methylisoindigotin, Dian III
Meisoindigo, a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
M2327 Daunorubicin hydrochloride DNA/RNA Synthesis
Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride
Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic.
M2329 Zoledronic acid PKC
Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects.
M2551 LY573636 (Tasisulam) Caspase
LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models.
M2565 PR-619 Deubiquitinase
PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis.
M2972 Q-VD-OPh Caspase
QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone
Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M2996 Salubrinal PERK
Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
M3001 SC144 IL Receptor/Related
SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells.
M3007 SF1126 PI3K
SF1126 is the RGDS-conjugated precursor of LY294002 and the first-in-class dual PI3K/BRD4 pan-inhibitor with anti-tumor and anti-angiogenic activities. It also induces apoptosis.
M3118 Verapamil hydrochloride Calcium Channel
(±)-Verapamil hydrochlorid
Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. In addition, Verapamil HCl also inhibits voltage-dependent K(+) (Kv) channels, decreasing Kv current amplitude in a concentration-dependent manner, with an apparent K(d) value of 0.82 for inhibition of Kv channels.
M3143 Z-VAD-FMK Caspase
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M3144 P7C3 NAMPT
P7C3 exerts its proneurogenic activity by protecting newborn neurons from apoptosis. Also enhances learning and memory in aged rats. Orally available and brain penetrant.
M3183 Quinacrine dihydrochloride Anti-infection
Mepacrine dihydrochloride; SN-390
Quinacrine dihydrochloride is a non-selective MAO-A/B inhibitor. Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis.
M3400 Idebenone Ferroptosis
Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells.
M3497 Simvastatin (MK 733) Autophagy
MK 733; MK-0733
Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
M3499 Ezetimibe Autophagy
SCH 58235
Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury.

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