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Apoptosis Activator 2

Cat. No. M2403
Apoptosis Activator 2 Structure
Synonym:

1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 48  USD48 In stock
10mg USD 60  USD60 In stock
25mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.It Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis.

Chemical Information
Molecular Weight 306.14
Formula C15H9Cl2NO2
CAS Number 79183-19-0
Solubility (25°C) DMSO 30 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Su-Been Lee, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A 2

[2] Jia Liu, et al. Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

[3] Chenggui Wang, et al. Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation

[4] Vitaliy O Kaminskyy, et al. Free radicals in cross talk between autophagy and apoptosis

[5] G M Cohen. Caspases: the executioners of apoptosis

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Keywords: Apoptosis Activator 2, 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione supplier, Caspase, inhibitors, activators


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