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Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis.
Z-VAD with radiation produces a significant tumor growth delay and shows dramatic antiangiogenic effect in cancer xenograft. Z-VAD induces both autophagy and necrosis in irradiated MDA-MB-231 and H460 mouse xenografts.
| Molecular Weight | 437.44 |
| Formula | C20H27N3O8 |
| CAS Number | 162852-62-2 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | -20°C, dry, sealed |
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