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LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models. LY573636 demonstrated activity across a broad range of tumors, including melanoma. LY573636 causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636 administered at a targeted C(max) of 420 μg/mL on Day 1 of 21-day cycles demonstrated activity and tolerable toxicity as second-line treatment in malignant melanoma. LY573636 is selectively toxic towards tumor cells over their normal counterparts.
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Source | Mol Cancer Ther (2011). Figure 1. LY 573636 |
| Method | FACS analysis | |
| Cell Lines | Calu-6 and A-375 cell | |
| Concentrations | from 200 mmol/L to approximately 200 nmol/L | |
| Incubation Time | 72 hours | |
| Results | Fluorescence-activated cell sorting (FACS) analysis of Calu-6 and A-375 cell lines showed that tasisulam induced a concentration-dependent increase in 4N DNA |
| Molecular Weight | 415.11 |
| Formula | C11H6BrCl2NO3S2 |
| CAS Number | 519055-62-0 |
| Solubility (25°C) | DMSO 73 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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