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Caspase Caspase

Cat.No.  Name Information
M6233 Z-YVAD-FMK Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M3532 VX-765 (Belnacasan) VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
M3143 Z-VAD-FMK Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M3134 Z-DEVD-FMK Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
M2972 Q-VD-OPh Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M30857 Penicillic acid  Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.
M30677 δ-Secretase inhibitor 11  δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase.
M30314 Heptelidic acid Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM.
M10931 KEA1-97 KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.
M10228 Caspase-9 Inhibitor III Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.
M9486 N-BOC-D-FMK N-BOC-D-FMK is a Caspase-3 inhibitor.
M9293 Z-Asp-CH2-DCB Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively.
M9065 Ac-DEVD-CHO Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM.
M8647 Raptinal Raptinal is a cell-permeable bifluorene-dicarbaldehyde compound that acts as a rapid activator of mitochondrial pathway-mediated intrinsic apoptosis.
M8348 2-HBA (HBB2) 2-HBA (HBB2) is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups.
M8340 Ac-YVAD-cmk Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4.
M7771 Phenoxodiol Phenoxodiol is a synthetic genestein analogue that activates the mitochondrial caspase system and inhibits XIAP, an inhibitor of apoptosis, making cancer cells sensitive to FAS - mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing cleavable complexes, thereby preventing DNA replication.
M6647 Cystamine dihydrochloride Cystamine dihydrochloride is a transglutaminase inhibitor; neuroprotective.
M6237 CA-074 CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
M6234 Z-FA-FMK Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.

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