Caspase Caspase

Inhibitors

Cat.No.	Name	Information
M3532	VX-765 (Belnacasan)	VX-765 is a potent and selective inhibitor of caspase-1 with K_i of 0.8 nM.
M3143	Z-VAD-FMK	Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M2972	Q-VD-OPh	Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M3134	Z-DEVD-FMK	Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
M6233	Z-YVAD-FMK	Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M13538	Z-WEHD-FMK	Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.
M13536	VRT-043198	VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.
M13535	Arnicolide D	Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima.
M10931	KEA1-97	KEA1-97 is a selective Thioretoxin-caspase 3 interaction interferer (IC50=10 μM)。 KEA1-97 disrupts the interaction of thioredoxin with caspase 3 without affecting thioredoxin activity, activates caspases, and induces cellular apoptosis.
M10905	Pralnacasan	Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis.
M10774	Ac-FLTD-CMK	Ac-FLTD-CMK is a gastrin D (GSDMD) derived inhibitor and is a specific inhibitor of inflammatory caspases. Ac-FLTD-CMK vs. caspases-1 (IC50 46.7 nM), caspases-4 (IC50 1.49 μM), caspases-5 (IC50 Both 329 nM) and caspases-11 are valid, but not for caspase-3 associated with apoptosis.
M10228	Caspase-9 Inhibitor III	Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.
M9486	N-BOC-D-FMK	N-BOC-D-FMK is a Caspase-3 inhibitor.
M9293	Z-Asp-CH2-DCB	Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively.
M9065	Ac-DEVD-CHO	Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM.
M8340	Ac-YVAD-cmk	Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4.
M6237	CA-074	CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
M6233	Z-YVAD-FMK	Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M6232	Z-LEED-FMK	Z-LEED-FMK is caspase-13 inhibitor.
M6231	Z-VAD(OH)-FMK	Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
M6128	BOC-D-FMK	Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
M5612	Emricasan	Emricasan is a potent irreversible pan-caspase inhibitor.
M5215	NQDI-1	NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
M4705	Asperosaponin-VI	Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
M4574	Wedelolactone	Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.

Signaling Pathways

Product Type

Caspase Caspase

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