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Caspase Caspase

Inhibitors

Cat.No.  Name Information
M3532 VX-765 (Belnacasan) VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
M3143 Z-VAD-FMK Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M2972 Q-VD-OPh Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M3134 Z-DEVD-FMK Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
M6233 Z-YVAD-FMK Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M13538 Z-WEHD-FMK Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.
M13537 Z-LEHD-FMK Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma.
M13536 VRT-043198 VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.
M13535 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima.
M10931 KEA1-97 KEA1-97 is a selective Thioretoxin-caspase 3 interaction interferer (IC50=10 μM)。 KEA1-97 disrupts the interaction of thioredoxin with caspase 3 without affecting thioredoxin activity, activates caspases, and induces cellular apoptosis.
M10905 Pralnacasan Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis.
M10774 Ac-FLTD-CMK Ac-FLTD-CMK is a gastrin D (GSDMD) derived inhibitor and is a specific inhibitor of inflammatory caspases. Ac-FLTD-CMK vs. caspases-1 (IC50 46.7 nM), caspases-4 (IC50 1.49 μM), caspases-5 (IC50 Both 329 nM) and caspases-11 are valid, but not for caspase-3 associated with apoptosis.
M10228 Caspase-9 Inhibitor III Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.
M9486 N-BOC-D-FMK N-BOC-D-FMK is a Caspase-3 inhibitor.
M9293 Z-Asp-CH2-DCB Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively.
M9065 Ac-DEVD-CHO Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM.
M8340 Ac-YVAD-cmk Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4.
M6237 CA-074 CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
M6233 Z-YVAD-FMK Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M6232 Z-LEED-FMK Z-LEED-FMK is caspase-13 inhibitor.
M6231 Z-VAD(OH)-FMK Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
M6128 BOC-D-FMK Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
M5612 Emricasan Emricasan is a potent irreversible pan-caspase inhibitor.
M5215 NQDI-1 NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
M4705 Asperosaponin-VI Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.



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