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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M3532 | VX-765 (Belnacasan) | VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M13538 | Z-WEHD-FMK | Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. |
| M13537 | Z-LEHD-FMK | Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma. |
| M13536 | VRT-043198 | VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. |
| M13535 | Arnicolide D | Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. |
| M10931 | KEA1-97 | KEA1-97 is a selective Thioretoxin-caspase 3 interaction interferer (IC50=10 μM)。 KEA1-97 disrupts the interaction of thioredoxin with caspase 3 without affecting thioredoxin activity, activates caspases, and induces cellular apoptosis. |
| M10905 | Pralnacasan | Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis. |
| M10774 | Ac-FLTD-CMK | Ac-FLTD-CMK is a gastrin D (GSDMD) derived inhibitor and is a specific inhibitor of inflammatory caspases. Ac-FLTD-CMK vs. caspases-1 (IC50 46.7 nM), caspases-4 (IC50 1.49 μM), caspases-5 (IC50 Both 329 nM) and caspases-11 are valid, but not for caspase-3 associated with apoptosis. |
| M10228 | Caspase-9 Inhibitor III | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9. |
| M9486 | N-BOC-D-FMK | N-BOC-D-FMK is a Caspase-3 inhibitor. |
| M9293 | Z-Asp-CH2-DCB | Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively. |
| M9065 | Ac-DEVD-CHO | Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM. |
| M8340 | Ac-YVAD-cmk | Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. |
| M6237 | CA-074 | CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M6232 | Z-LEED-FMK | Z-LEED-FMK is caspase-13 inhibitor. |
| M6231 | Z-VAD(OH)-FMK | Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. |
| M6128 | BOC-D-FMK | Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
| M5612 | Emricasan | Emricasan is a potent irreversible pan-caspase inhibitor. |
| M5215 | NQDI-1 | NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM. |
| M4705 | Asperosaponin-VI | Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. |
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