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δ-Secretase inhibitor 11 

Cat. No. M30677
δ-Secretase inhibitor 11  Structure
Size Price Availability Quantity
10mg USD 80  USD80 In stock
25mg USD 160  USD160 In stock
50mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research.

Chemical Information
Molecular Weight 220.23
Formula C10H12N4O2
CAS Number 842964-18-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Ju Wang, et al. Transl Neurodegener. Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model

[2] Ting Yu, et al. Eur J Pharmacol. Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation

[3] Zhentao Zhang, et al. Nat Commun. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease

[4] Chun-Wai Mai, et al. Curr Drug Targets. Targeting Legumain As a Novel Therapeutic Strategy in Cancers

[5] Kazumi Ishidoh, et al. Biol Chem. Processing and activation of lysosomal proteinases

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Abmole Inhibitor Catalog

Keywords: δ-Secretase inhibitor 11  supplier, Caspase, inhibitors, activators

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