Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
Front Microbiol. 2023 Mar 2;14:1120048.
Specific TLR-mediated HSP70 activation plays a potential role in host defense against the intestinal parasite Giardia duodenalis
Q-VD-OPh purchased from AbMole
Microb Pathog. 2020 Dec;149:104315.
Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro
Q-VD-OPh purchased from AbMole
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Source | Microb Pathog (2020 Dec). Figure 6. Q-VD-OPh (Abmole Bioscience, US) |
| Method | cell viability | |
| Cell Lines | Caco-2 cells | |
| Concentrations | 50 μM | |
| Incubation Time | 6 h | |
| Results | Giardia-induced Caco-2 cell apoptosis was dependent on CASP3/8 activation, as co-incubation of Caco-2 cells with Q-VD-O weakened the ability of trophozoites to induce apoptosis after 6 h of incubation. |
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Source | J Clin Invest (2018). Figure 1. Q-VD-OPh |
| Method | cell proliferation assay | |
| Cell Lines | CD3+CD8+ T cells | |
| Concentrations | - | |
| Incubation Time | 24 h | |
| Results | Our results showed that Q-VD-OPH inhibits spontaneous cell death of CD4+ T cells isolated from peripheral lymph nodes (LNs) (axillary and inguinal) and spleen of SIVinfected RMs |
| Molecular Weight | 513.49 |
| Formula | C26H25F2N3O6 |
| CAS Number | 1135695-98-5 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Thomas L Brown. Q-VD-OPh, next generation caspase inhibitor
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