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Cat. No. M2972
Q-VD-OPh Structure

QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone

Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 105  USD105 In stock
10mg USD 190  USD190 In stock
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Quality Control & Documentation
Biological Activity

Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.

Product Citations
Customer Product Validations & Biological Datas
Source Microb Pathog (2020 Dec). Figure 6. Q-VD-OPh (Abmole Bioscience, US)
Method cell viability
Cell Lines Caco-2 cells
Concentrations 50 μM
Incubation Time 6 h
Results Giardia-induced Caco-2 cell apoptosis was dependent on CASP3/8 activation, as co-incubation of Caco-2 cells with Q-VD-O weakened the ability of trophozoites to induce apoptosis after 6 h of incubation.
Source J Clin Invest (2018). Figure 1. Q-VD-OPh
Method cell proliferation assay
Cell Lines CD3+CD8+ T cells
Concentrations -
Incubation Time 24 h
Results Our results showed that Q-VD-OPH inhibits spontaneous cell death of CD4+ T cells isolated from peripheral lymph nodes (LNs) (axillary and inguinal) and spleen of SIVinfected RMs
Chemical Information
Molecular Weight 513.49
Formula C26H25F2N3O6
CAS Number 1135695-98-5
Solubility (25°C) DMSO 90 mg/mL
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] A Colak, et al. Q-VD-OPh, a pancaspase inhibitor, reduces trauma-induced apoptosis and improves the recovery of hind-limb function in rats after spinal cord injury

[2] Chanel Li Keoni, et al. Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease

[3] Thomas L Brown. Q-VD-OPh, next generation caspase inhibitor

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Abmole Inhibitor Catalog

Keywords: Q-VD-OPh, QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone supplier, Caspase, inhibitors, activators

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