All AbMole products are for research use only, cannot be used for human consumption.
Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
J Hazard Mater. 2021 Aug 15;416:126138.
New insights into crosstalk between pyroptosis and autophagy co-induced by molybdenum and cadmium in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
2021 May 25 .
Caspase-1 Inhibitor Reduces Pyroptosis in Kidney Injury Induced by Brain Death
Z-YVAD-FMK purchased from AbMole
Environ Pollut. 2020 Oct 23;273:115919.
Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
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Source | Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK |
| Method | western blotting | |
| Cell Lines | GBM cells | |
| Concentrations | 20 μM | |
| Incubation Time | 3 h | |
| Results | To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death. |
| Molecular Weight | 630.66 |
| Formula | C31H39FN4O9 |
| CAS Number | 210344-97-1 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Caspase Products |
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TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death. |
| Ac-Ile-Glu-Thr-Asp-pNA
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. |
| Z-DEVD-AFC
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. |
| Ac-IETD-AFC
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B. |
| Z-VDVAD-FMK
Z-VDVAD-FMK is a special inhibitor of caspase-2. |
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