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Z-YVAD-FMK

Cat. No. M6233
Z-YVAD-FMK Structure
Size Price Availability Quantity
2mg USD 243  USD270 In stock
5mg USD 495  USD550 In stock
10mg USD 810  USD900 In stock
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Quality Control
Biological Activity

Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.

Product Citations
Customer Product Validations & Biological Datas
Source Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK
Method western blotting
Cell Lines GBM cells
Concentrations 20 μM
Incubation Time 3 h
Results To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 630.66
Formula C31H39FN4O9
CAS Number 210344-97-1
Purity >98%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.
Gicquel T, et al. FASEB J. 2015 Oct;29(10):4162-73. PMID: 26116704.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, et al. Nat Immunol. 2014 Aug;15(8):727-37. PMID: 24952505.

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  Catalog
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Keywords: Z-YVAD-FMK supplier, Caspase, inhibitors

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