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Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
J Hazard Mater. 2021 Aug 15;416:126138.
New insights into crosstalk between pyroptosis and autophagy co-induced by molybdenum and cadmium in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
2021 May 25 .
Caspase-1 Inhibitor Reduces Pyroptosis in Kidney Injury Induced by Brain Death
Z-YVAD-FMK purchased from AbMole
Environ Pollut. 2020 Oct 23;273:115919.
Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells
Z-YVAD-FMK purchased from AbMole
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Source | Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK |
| Method | western blotting | |
| Cell Lines | GBM cells | |
| Concentrations | 20 μM | |
| Incubation Time | 3 h | |
| Results | To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death. |
| Molecular Weight | 630.66 |
| Formula | C31H39FN4O9 |
| CAS Number | 210344-97-1 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Caspase Products |
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Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. |
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| MMPSI
MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. |
| Ivachtin
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| VMY-1-103
VMY-1-103 is an inhibitor for cyclin/Cdk complex, that arrests the cell cycle at G1 phase. |
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Products are for research use only. Not for human use. We do not sell to patients.
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