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Cat. No. M6233
Z-YVAD-FMK Structure
Size Price Availability Quantity
1mg USD 200  USD200 In stock
5mg USD 475  USD475 In stock
10mg USD 790  USD790 In stock
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Quality Control & Documentation
Biological Activity

Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.

Product Citations
Customer Product Validations & Biological Datas
Source Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK
Method western blotting
Cell Lines GBM cells
Concentrations 20 μM
Incubation Time 3 h
Results To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death.
Chemical Information
Molecular Weight 630.66
Formula C31H39FN4O9
CAS Number 210344-97-1
Solubility (25°C) DMSO: ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Gicquel T, et al. FASEB J. IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.

[2] Franklin BS, et al. Nat Immunol. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

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Keywords: Z-YVAD-FMK supplier, Caspase, inhibitors, activators

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