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Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
Microbiol Spectr. 2023 Apr 20;e0475322.
MARCO Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection through Intensifying Viral GP5-Induced Apoptosis
Z-DEVD-FMK purchased from AbMole
Front Mol Biosci. 2022 Aug 15;9:895795.
Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes
Z-DEVD-FMK purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
Z-DEVD-FMK purchased from AbMole
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Source | Oncotarget (2018). Figure 5. Z-DEVD-FMK |
| Method | FACS | |
| Cell Lines | CEM/VLB100 cells | |
| Concentrations | 25 μM | |
| Incubation Time | 24 h | |
| Results | CEM/VLB100 cells were treated with CCB in the presence of Z-DEVD-FMK, and cell death was determined by flow cytometry. Z-DEVDFMK was not able to prevent CCB-induced apoptotic cell death, indicating the existence of a caspaseindependent type of cell death. |
| Molecular Weight | 668.66 |
| Formula | C30H41FN4O12 |
| CAS Number | 210344-95-9 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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