| Cat.No. | Name | Information |
|---|---|---|
| M3532 | Belnacasan | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M2403 | MDK83190 | MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| M9065 | Ac-DEVD-CHO | Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM. |
| M8647 | Raptinal | Raptinal is a cell-permeable bifluorene-dicarbaldehyde compound that acts as a rapid activator of mitochondrial pathway-mediated intrinsic apoptosis. |
| M8348 | 2-HBA (HBB2) | 2-HBA (HBB2) is an inducer of the KEAP1/NRF2/ARE pathway that reacts with sulfhydryl groups. |
| M8340 | Ac-YVAD-cmk | Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. |
| M7771 | Phenoxodiol | Phenoxodiol is a synthetic genestein analogue that activates the mitochondrial caspase system and inhibits XIAP, an inhibitor of apoptosis, making cancer cells sensitive to FAS - mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing cleavable complexes, thereby preventing DNA replication. |
| M7112 | PETCM | PETCM is a activator of caspase-3. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells. |
| M6647 | Cystamine dihydrochloride | Cystamine dihydrochloride is a transglutaminase inhibitor; neuroprotective. |
| M6237 | CA-074 | CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. |
| M6234 | Z-FA-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases. |
| M6232 | Z-LEED-FMK | Z-LEED-FMK is caspase-13 inhibitor. |
| M6231 | Z-VAD(OH)-FMK | Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. |
| M6128 | BOC-D-FMK | Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
| M5612 | Emricasan | Emricasan is a potent irreversible pan-caspase inhibitor. |
| M5215 | NQDI-1 | NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM. |
| M4705 | Asperosaponin-VI | Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. |
| M4574 | Wedelolactone | Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11. |
| M4428 | Senkyunolide-I | Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3. |
| M4070 | (S)Ginsenoside-Rh2 | (S)Ginsenoside-Rh2 is isolated from the root of Ginseng, induces the activation of caspase-8 and caspase-9. |
| M4009 | Licochalcone-B | Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. |
| M3136 | Z-IETD-FMK | Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
