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Caspase Caspase

Cat.No.  Name Information
M3143 Z-VAD-FMK Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M2972 Q-VD-OPh Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M3134 Z-DEVD-FMK Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
M6233 Z-YVAD-FMK Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
M2403 Apoptosis Activator 2 Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
M6232 Z-LEED-FMK Z-LEED-FMK is caspase-13 inhibitor.
M6231 Z-VAD(OH)-FMK Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
M6128 BOC-D-FMK Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
M5612 Emricasan Emricasan is a potent irreversible pan-caspase inhibitor.
M5215 NQDI-1 NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
M4705 Asperosaponin-VI Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
M4574 Wedelolactone Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.
M4428 Senkyunolide-I Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3.
M4070 (S)Ginsenoside-Rh2 (S)Ginsenoside-Rh2 is isolated from the root of Ginseng, induces the activation of caspase-8 and caspase-9.
M4009 Licochalcone-B Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata.
M3136 Z-IETD-FMK Z-IETD-FMK is a specific Caspase-8 inhibitor.
M2551 LY573636 (Tasisulam) LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models.
M2403 Apoptosis Activator 2 Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
M1867 PAC-1 PAC-1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM).
M54350 Ac-Ile-Glu-Thr-Asp-pNA Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.
M54185 Z-DEVD-AFC Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore.
M53975 Ac-IETD-AFC Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B.
M53846 Z-VDVAD-FMK Z-VDVAD-FMK is a special inhibitor of caspase-2.
M53408 Z-LEED-FMK Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor.
M53407 Z-VEID-FMK Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor.




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