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Ac-YVAD-cmk

Cat. No. M8340

All AbMole products are for research use only, cannot be used for human consumption.

Ac-YVAD-cmk Structure
Synonym:

Caspase-1 Inhibitor II

Size Price Availability Quantity
1mg USD 80  USD80 In stock
5mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

Chemical Information
Molecular Weight 540.99
Formula C24H33ClN4O8
CAS Number 178603-78-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Pan Pan, et al. SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

[2] Mei Yang, et al. Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis

[3] Hongsheng Liang, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats

[4] Zhen Qiu, et al. Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

[5] Xiao Lin, et al. AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage

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Keywords: Ac-YVAD-cmk, Caspase-1 Inhibitor II supplier, Caspase, inhibitors, activators

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