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N-BOC-D-FMK

Cat. No. M9486
N-BOC-D-FMK Structure
Synonym:

Caspase Inhibitor 3

Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 220  USD220 In stock
25mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

N-BOC-D-FMK is a Caspase-3 inhibitor.

Chemical Information
Molecular Weight 263.26
Formula C11H18FNO5
CAS Number 187389-53-3
Solubility (25°C) DMSO 10mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefan Landgraeber, et al. Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis

[2] Shyr-Ming Sheen-Chen, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge

[3] Su-Bog Yee, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells

[4] Andrew S Cowburn, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

[5] Chengbin Lin, et al. Caspase activation in equine influenza virus induced apoptotic cell death

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  Catalog
Abmole Inhibitor Catalog




Keywords: N-BOC-D-FMK, Caspase Inhibitor 3 supplier, Caspase, inhibitors, activators


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