| Cat.No. | Name | Information |
|---|---|---|
| M3532 | Belnacasan | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M2403 | MDK83190 | MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| M53377 | Z-YVAD-pNA | Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate. |
| M53376 | Z-VAD-AMC | Z-VAD-AMC is a substrate of caspase-9. |
| M53375 | TRP-601 | TRP-601 is a caspase inhibitor. |
| M53374 | GPR | GPR is a three amino acid peptide. |
| M49832 | Procaspase-3/6 activator 1 | Procaspase-3/6 activator 1 is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. |
| M45314 | Ac-ESMD-CHO | Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7 that inhibits the proteolytic cleavage of caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site. |
| M45309 | Ac-VDVAD-CHO | Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46/15 nM). |
| M41333 | IETD-CHO | IETD-CHO (Caspase-8-IN-1) is a potent caspase-8 inhibitor. |
| M41332 | IETD-CHO TFA | IETD-CHO TFA (Caspase-8-IN-1) is a potent caspase-8 inhibitor. |
| M41331 | Ac-DEVD-CMK TFA | Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible caspase-3 inhibitor. |
| M41330 | M867 | M867 is a selective and reversible inhibitor of caspase-3 with an IC50 of 1.4 nM and Ki of 0.7 nM. |
| M41329 | M826 | M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3. |
| M38856 | Cimiside E | Cimiside E (25-Anhydrocimigenol xyloside) possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways. |
| M38855 | Trijuganone C | Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation. |
| M30938 | QM31 | QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. |
| M29004 | Ac-DEVD-pNA | Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases. |
| M13538 | Z-WEHD-FMK | Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. |
| M13536 | VRT-043198 | VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. |
| M10905 | Pralnacasan | Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis. |
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