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QM31

Cat. No. M30938

All AbMole products are for research use only, cannot be used for human consumption.

QM31 Structure
Synonym:

SVT016426

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Quality Control & Documentation
Biological Activity

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

Chemical Information
Molecular Weight 768.56
Formula C39H38Cl4N4O4
CAS Number 937735-00-7
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Vicente Andreu-Fernández, et al. PLoS One. BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components

[2] Laura Mondragón, et al. Apoptosis. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

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  Catalog
Abmole Inhibitor Catalog




Keywords: QM31, SVT016426 supplier, Caspase, inhibitors, activators

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