| Cat.No. | Name | Information |
|---|---|---|
| M3532 | Belnacasan | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M2403 | MDK83190 | MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| M53397 | Mca-DEVDAP-K(Dnp)-OH | Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3. |
| M53396 | Z-LE(OMe)TD(OMe)-FMK | Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. |
| M53395 | Boc-Ala-Ala-Asp-pNA | Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. |
| M53394 | Z-Ala-Ala-Asp-CMK | Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. |
| M53393 | Biotin-DEVD-CHO | Biotin-DEVD-CHO can be used for affinity labeling of Caspase-8 following in vitro caspase cleavage. |
| M53392 | Tripeptide-32 | Tripeptide-32isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient. |
| M53391 | Ac-VDVAD-pNA | Ac-VDVAD-pNA is a caspase-2 substrate. |
| M53390 | Boc-AEVD-CHO | Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases. |
| M53389 | Ac-DEVD-CMK | Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. |
| M53388 | Ac-DMQD-AMC | Ac-DMQD-AMC is an inhibitor of caspase-3. |
| M53387 | Ac-DNLD-CHO | Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively). |
| M53386 | Ac-LEVD-CHO | Ac-LEVD-CHO is a caspase-4 inhibitor. |
| M53385 | Ac-VETD-AMC | Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. |
| M53384 | Ac-VRPR-AMC | Ac-VRPR-AMC is a fluorogenic metacaspase substrate. |
| M53383 | Ac-YVAD-AOM | Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity. |
| M53382 | Ac-VAD-CHO | Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. |
| M53381 | Ac-VAD-pNA | Ac-VAD-pNA is a caspase-1 substrate. |
| M53380 | Z-IETD-pNA | Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. |
| M53379 | Z-VEID-AFC | Z-VEID-AFC is a fluorescent substrate for caspase-6. |
| M53378 | Z-YVAD-CMK | Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor. |
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