| Cat.No. | Name | Information |
|---|---|---|
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M3532 | Belnacasan | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| M3143 | Z-VAD-FMK | Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor with an IC50 of 18 μM, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M2403 | MDK83190 | MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| M58488 | Z-VAD | Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. |
| M54520 | TC11 | TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death. |
| M53975 | Ac-IETD-AFC | Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B. |
| M45397 | Z-LEVD-FMK | Z-LEVD-FMK is a cell-permeable Caspase-4 inhibitor that blocks ER stress-induced apoptosis in cancer cells. |
| M30857 | Penicillic acid | Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8. |
| M30677 | δ-Secretase inhibitor 11 | δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. |
| M30314 | Heptelidic acid | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM. |
| M30240 | Z-LEHD-FMK TFA | Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma. |
| M13535 | Arnicolide D | Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. |
| M10931 | KEA1-97 | KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. |
| M10774 | Ac-FLTD-CMK | Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3. |
| M10228 | Caspase-9 Inhibitor III | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9. |
| M9486 | N-BOC-D-FMK | N-BOC-D-FMK (Boc-D(OMe)-FMK) is a broad range caspase inhibitor. N-BOC-D-FMK inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8. |
| M9293 | Z-Asp-CH2-DCB | Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively. |
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