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Penicillic acid 

Cat. No. M30857
Penicillic acid  Structure
Size Price Availability Quantity
5mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.

Chemical Information
Molecular Weight 170.16
Formula C8H10O4
CAS Number 90-65-3
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Water 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Gabrielle Vieira, et al. J Appl Microbiol. Isolation and agricultural potential of penicillic acid against citrus canker

[2] Wenbi Guan, et al. J Sci Food Agric. Penicillic acid in fruits: method development, validation by liquid chromatography-tandem mass spectrometry and survey in southern China

[3] Birgit Puschner. Vet Clin North Am Small Anim Pract. Mycotoxins

[4] W G Sorenson, et al. Environ Res. Toxicity of penicillic acid for rat alveolar macrophages in vitro

[5] No authors listed. IARC Monogr Eval Carcinog Risk Chem Man. Penicillic acid

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Abmole Inhibitor Catalog

Keywords: Penicillic acid  supplier, Caspase, inhibitors, activators

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