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Z-IETD-FMK

Cat. No. M3136

All AbMole products are for research use only, cannot be used for human consumption.

Z-IETD-FMK Structure
Synonym:

Caspase-8 Inhibitor; Z-IE(OMe)TD(OMe)-FMK

Size Price Availability Quantity
1mg USD 140  USD140 In stock
5mg USD 310  USD310 In stock
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Quality Control & Documentation
Biological Activity

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor.

Customer Product Validations & Biological Datas
Source Mar Drugs (2018). Figure 6. Z-IETD-FMK
Method MTT assay
Cell Lines MG63 cells
Concentrations 10 μM
Incubation Time 24 h
Results These data indicated that MSP-4 induced cytotoxicity and caspase-dependent apoptosis, but pretreatment with Z-IETD-FMK (caspase-8 inhibitor) or Z-LEHD-FMK (caspase-9 inhibitor) sharply suppressed the cells’ cytotoxicity and caspase expression in Western blots.
Chemical Information
Molecular Weight 654.68
Formula C30H43FN4O11
CAS Number 210344-98-2
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Y Niu, et al. The application of apoptotic inhibitor in apoptotic pathways of MII stage porcine oocytes after vitrification

[2] Wei Chi, et al. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

[3] C P Lawrence, et al. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties

[4] Andrew S Cowburn, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

[5] N Ozoren, et al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand

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Keywords: Z-IETD-FMK, Caspase-8 Inhibitor; Z-IE(OMe)TD(OMe)-FMK supplier, Caspase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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